Anti-inflammatory activity of methanolic extracts from edible mushrooms in LPS activated RAW 264.7 macrophages

Nowadays there is a great interest in the use of edible mushrooms as functional food since they are rich in bioactive compounds. Although their immunomostimulant activity has been largely demonstrated, their potential anti-inflammatory activity has been scarcely explored. We have investigated the anti-inflammatory activity of methanolic extracts from different edible mushrooms species Agaricus bisporus, Boletus edulis, Cantherellus cibarius, Cratarellus cornucopioides, Lactarius deliciosus and Pleurotus ostreatus, in activated macrophages. The species that exhibited higher anti-inflammatory activities were A. bisporus, C. cibarius and L. deliciosus, inducing inhibition of NO production and iNOS, IL-1β and IL6 mRNAs expression in response to LPS stimulation. C. cornucopioides only induced inhibition of NO production and iNOS expression, and the other species did not present anti-inflammatory effects. Therefore, some edible mushrooms species have a potential anti-inflammatory capacity in vitro, suggesting that they could be regarded as a potential source of natural anti-inflammatory agents.

Bibliographic Details

Main Authors:	Moro, C., Palacios, I., Lozano, M., D'Arrigo, M., Guillamón Fernández, Eva, Villares, A., Martínez, J. A., García Lafuente, Ana María
Format:	journal article biblioteca
Language:	English
Published:	Elsevier 2012
Subjects:	Edible mushrooms, Methanolic extracts, Phenolic compounds, Anti-inflammatory activity,
Online Access:	http://hdl.handle.net/20.500.12792/3028 http://hdl.handle.net/10261/293273
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