QTL detection on porcine chromosome 12 for fatty-acid composition and association analyses of the fatty acid synthase, gastric inhibitory polypeptide and acetyl-coenzyme A carboxylase alpha genes
Refinement of previous QTL on porcine chromosome 12 for fatty-acid composition and a candidate gene association analysis were conducted using an Iberian x Landrace cross. The concentrations of ten fatty acids were assayed in backfat tissue from which four metabolic ratios were calculated for 403 F 2 animals. Linkage analysis identified two significant QTL. The first QTL was associated with the average chain length ratio and the percentages of myristic, palmitic and gadoleic acids. The second QTL was associated with percentages of palmitoleic, stearic and vaccenic acids. Based upon its position on SSC12, fatty acid synthase was tested as a candidate gene for the first QTL and no significant effects were found. Similarly, gastric inhibitory polypeptide (GIP) and acetyl-coenzyme A carboxylase alpha (ACACA) were tested as candidate genes for the second QTL using three SNPs in GIP and 15 synonymous SNPs in ACACA cDNA sequences. Two missense SNPs in GIP showed significant effects with palmitoleic and stearic fatty-acid concentration. Highly significant associations were found for two SNPs in ACACA with stearic, palmitoleic and vaccenic fatty-acid concentrations. These associations could be due to linkage disequilibrium with the causal mutations. © 2007 The Authors.
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Wiley
2007
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Subjects: | Acetyl-coenzyme A carboxylase alpha, Fatty acid synthase, Fatty-acid composition, Gastric inhibitory polypeptide, Pig, Quantitative trait locus, |
Online Access: | http://hdl.handle.net/20.500.12792/3048 http://hdl.handle.net/10261/293259 |
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dig-inia-es-10261-2932592023-02-20T10:26:42Z QTL detection on porcine chromosome 12 for fatty-acid composition and association analyses of the fatty acid synthase, gastric inhibitory polypeptide and acetyl-coenzyme A carboxylase alpha genes Muñoz, G. Alves, E. Fernández, A. Óvilo Martín, Cristina Barragán, C. Estellé, J. Quintanilla, R. Folch, J. M. Silió, L. Rodríguez, M. C. Fernández, A. I. Acetyl-coenzyme A carboxylase alpha Fatty acid synthase Fatty-acid composition Gastric inhibitory polypeptide Pig Quantitative trait locus Refinement of previous QTL on porcine chromosome 12 for fatty-acid composition and a candidate gene association analysis were conducted using an Iberian x Landrace cross. The concentrations of ten fatty acids were assayed in backfat tissue from which four metabolic ratios were calculated for 403 F 2 animals. Linkage analysis identified two significant QTL. The first QTL was associated with the average chain length ratio and the percentages of myristic, palmitic and gadoleic acids. The second QTL was associated with percentages of palmitoleic, stearic and vaccenic acids. Based upon its position on SSC12, fatty acid synthase was tested as a candidate gene for the first QTL and no significant effects were found. Similarly, gastric inhibitory polypeptide (GIP) and acetyl-coenzyme A carboxylase alpha (ACACA) were tested as candidate genes for the second QTL using three SNPs in GIP and 15 synonymous SNPs in ACACA cDNA sequences. Two missense SNPs in GIP showed significant effects with palmitoleic and stearic fatty-acid concentration. Highly significant associations were found for two SNPs in ACACA with stearic, palmitoleic and vaccenic fatty-acid concentrations. These associations could be due to linkage disequilibrium with the causal mutations. © 2007 The Authors. 2023-02-20T10:26:42Z 2023-02-20T10:26:42Z 2007 journal article Animal Genetics 38(6): 639-646 (2007) 0268-9146 http://hdl.handle.net/20.500.12792/3048 http://hdl.handle.net/10261/293259 10.1111/j.1365-2052.2007.01668.x 1365-2052 en none Wiley |
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Acetyl-coenzyme A carboxylase alpha Fatty acid synthase Fatty-acid composition Gastric inhibitory polypeptide Pig Quantitative trait locus Acetyl-coenzyme A carboxylase alpha Fatty acid synthase Fatty-acid composition Gastric inhibitory polypeptide Pig Quantitative trait locus |
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Acetyl-coenzyme A carboxylase alpha Fatty acid synthase Fatty-acid composition Gastric inhibitory polypeptide Pig Quantitative trait locus Acetyl-coenzyme A carboxylase alpha Fatty acid synthase Fatty-acid composition Gastric inhibitory polypeptide Pig Quantitative trait locus Muñoz, G. Alves, E. Fernández, A. Óvilo Martín, Cristina Barragán, C. Estellé, J. Quintanilla, R. Folch, J. M. Silió, L. Rodríguez, M. C. Fernández, A. I. QTL detection on porcine chromosome 12 for fatty-acid composition and association analyses of the fatty acid synthase, gastric inhibitory polypeptide and acetyl-coenzyme A carboxylase alpha genes |
description |
Refinement of previous QTL on porcine chromosome 12 for fatty-acid composition and a candidate gene association analysis were conducted using an Iberian x Landrace cross. The concentrations of ten fatty acids were assayed in backfat tissue from which four metabolic ratios were calculated for 403 F 2 animals. Linkage analysis identified two significant QTL. The first QTL was associated with the average chain length ratio and the percentages of myristic, palmitic and gadoleic acids. The second QTL was associated with percentages of palmitoleic, stearic and vaccenic acids. Based upon its position on SSC12, fatty acid synthase was tested as a candidate gene for the first QTL and no significant effects were found. Similarly, gastric inhibitory polypeptide (GIP) and acetyl-coenzyme A carboxylase alpha (ACACA) were tested as candidate genes for the second QTL using three SNPs in GIP and 15 synonymous SNPs in ACACA cDNA sequences. Two missense SNPs in GIP showed significant effects with palmitoleic and stearic fatty-acid concentration. Highly significant associations were found for two SNPs in ACACA with stearic, palmitoleic and vaccenic fatty-acid concentrations. These associations could be due to linkage disequilibrium with the causal mutations. © 2007 The Authors. |
format |
journal article |
topic_facet |
Acetyl-coenzyme A carboxylase alpha Fatty acid synthase Fatty-acid composition Gastric inhibitory polypeptide Pig Quantitative trait locus |
author |
Muñoz, G. Alves, E. Fernández, A. Óvilo Martín, Cristina Barragán, C. Estellé, J. Quintanilla, R. Folch, J. M. Silió, L. Rodríguez, M. C. Fernández, A. I. |
author_facet |
Muñoz, G. Alves, E. Fernández, A. Óvilo Martín, Cristina Barragán, C. Estellé, J. Quintanilla, R. Folch, J. M. Silió, L. Rodríguez, M. C. Fernández, A. I. |
author_sort |
Muñoz, G. |
title |
QTL detection on porcine chromosome 12 for fatty-acid composition and association analyses of the fatty acid synthase, gastric inhibitory polypeptide and acetyl-coenzyme A carboxylase alpha genes |
title_short |
QTL detection on porcine chromosome 12 for fatty-acid composition and association analyses of the fatty acid synthase, gastric inhibitory polypeptide and acetyl-coenzyme A carboxylase alpha genes |
title_full |
QTL detection on porcine chromosome 12 for fatty-acid composition and association analyses of the fatty acid synthase, gastric inhibitory polypeptide and acetyl-coenzyme A carboxylase alpha genes |
title_fullStr |
QTL detection on porcine chromosome 12 for fatty-acid composition and association analyses of the fatty acid synthase, gastric inhibitory polypeptide and acetyl-coenzyme A carboxylase alpha genes |
title_full_unstemmed |
QTL detection on porcine chromosome 12 for fatty-acid composition and association analyses of the fatty acid synthase, gastric inhibitory polypeptide and acetyl-coenzyme A carboxylase alpha genes |
title_sort |
qtl detection on porcine chromosome 12 for fatty-acid composition and association analyses of the fatty acid synthase, gastric inhibitory polypeptide and acetyl-coenzyme a carboxylase alpha genes |
publisher |
Wiley |
publishDate |
2007 |
url |
http://hdl.handle.net/20.500.12792/3048 http://hdl.handle.net/10261/293259 |
work_keys_str_mv |
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