Oviductal secretions Will they be key factors for the future ARTs?
A variety of evolutionary processes has led to the development of different organs to ensure that internal fertilization occur successfully. Fallopian tubes are a particularly interesting example of such organs. Some of the key events during fertilization and early embryo development occur in the oviduct. Knowledge of the different components described in the oviduct is extensive. Oviductal components include hormones, growth factors and their receptors that have important roles in the physiology of the oviduct and embryo development. Other oviductal factors protect the gamete and the embryos against oxidative stress and pathogens. Different proteins and enzymes are present in the oviductal fluid and have the ability to interact with the oocyte and the sperm before the fertilization occurs. Of special interest is the oviduct-specific glycoprotein (OVGP1), a glycoprotein that is conserved in different mammals, and its association with the zona pellucida (ZP). Interaction of the oocyte with oviductal secretions leads us to emphasize the concept of 'ZP maturation' within the oviduct. The ZP changes produced in the oviduct result in an increased efficiency of the in vitro fertilization technique in some animal models, contributing in particular to the control of polyspermy and suggesting that a similar role could be played by oviductal factors in human beings. Finally, attention should be given to the presence in the oviductal fluid of several embryotrophic factors and their importance in relation to the in vivo versus in vitro developmental ability of the embryos. © The Author 2010. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology.
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Format: | review biblioteca |
Language: | English |
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Oxford University Press
2010
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Subjects: | Oviduct-specific glycoprotein, Concept of zona pellucida maturation, Oviductal secretions, In vitro development, Embryo_x0002_trophic factor, |
Online Access: | http://hdl.handle.net/20.500.12792/2308 http://hdl.handle.net/10261/293253 |
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dig-inia-es-10261-2932532023-02-20T10:26:39Z Oviductal secretions Will they be key factors for the future ARTs? Avilés, M. Gutiérrez Adán, Alfonso Coy, P. Oviduct-specific glycoprotein Concept of zona pellucida maturation Oviductal secretions In vitro development Embryo_x0002_trophic factor A variety of evolutionary processes has led to the development of different organs to ensure that internal fertilization occur successfully. Fallopian tubes are a particularly interesting example of such organs. Some of the key events during fertilization and early embryo development occur in the oviduct. Knowledge of the different components described in the oviduct is extensive. Oviductal components include hormones, growth factors and their receptors that have important roles in the physiology of the oviduct and embryo development. Other oviductal factors protect the gamete and the embryos against oxidative stress and pathogens. Different proteins and enzymes are present in the oviductal fluid and have the ability to interact with the oocyte and the sperm before the fertilization occurs. Of special interest is the oviduct-specific glycoprotein (OVGP1), a glycoprotein that is conserved in different mammals, and its association with the zona pellucida (ZP). Interaction of the oocyte with oviductal secretions leads us to emphasize the concept of 'ZP maturation' within the oviduct. The ZP changes produced in the oviduct result in an increased efficiency of the in vitro fertilization technique in some animal models, contributing in particular to the control of polyspermy and suggesting that a similar role could be played by oviductal factors in human beings. Finally, attention should be given to the presence in the oviductal fluid of several embryotrophic factors and their importance in relation to the in vivo versus in vitro developmental ability of the embryos. © The Author 2010. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. 2023-02-20T10:26:39Z 2023-02-20T10:26:39Z 2010 review Molecular Human Reproduction 16(12): 896-906 (2010) 1360-9947 http://hdl.handle.net/20.500.12792/2308 http://hdl.handle.net/10261/293253 10.1093/molehr/gaq056 1460-2407 en none Oxford University Press |
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Oviduct-specific glycoprotein Concept of zona pellucida maturation Oviductal secretions In vitro development Embryo_x0002_trophic factor Oviduct-specific glycoprotein Concept of zona pellucida maturation Oviductal secretions In vitro development Embryo_x0002_trophic factor |
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Oviduct-specific glycoprotein Concept of zona pellucida maturation Oviductal secretions In vitro development Embryo_x0002_trophic factor Oviduct-specific glycoprotein Concept of zona pellucida maturation Oviductal secretions In vitro development Embryo_x0002_trophic factor Avilés, M. Gutiérrez Adán, Alfonso Coy, P. Oviductal secretions Will they be key factors for the future ARTs? |
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A variety of evolutionary processes has led to the development of different organs to ensure that internal fertilization occur successfully. Fallopian tubes are a particularly interesting example of such organs. Some of the key events during fertilization and early embryo development occur in the oviduct. Knowledge of the different components described in the oviduct is extensive. Oviductal components include hormones, growth factors and their receptors that have important roles in the physiology of the oviduct and embryo development. Other oviductal factors protect the gamete and the embryos against oxidative stress and pathogens. Different proteins and enzymes are present in the oviductal fluid and have the ability to interact with the oocyte and the sperm before the fertilization occurs. Of special interest is the oviduct-specific glycoprotein (OVGP1), a glycoprotein that is conserved in different mammals, and its association with the zona pellucida (ZP). Interaction of the oocyte with oviductal secretions leads us to emphasize the concept of 'ZP maturation' within the oviduct. The ZP changes produced in the oviduct result in an increased efficiency of the in vitro fertilization technique in some animal models, contributing in particular to the control of polyspermy and suggesting that a similar role could be played by oviductal factors in human beings. Finally, attention should be given to the presence in the oviductal fluid of several embryotrophic factors and their importance in relation to the in vivo versus in vitro developmental ability of the embryos. © The Author 2010. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. |
format |
review |
topic_facet |
Oviduct-specific glycoprotein Concept of zona pellucida maturation Oviductal secretions In vitro development Embryo_x0002_trophic factor |
author |
Avilés, M. Gutiérrez Adán, Alfonso Coy, P. |
author_facet |
Avilés, M. Gutiérrez Adán, Alfonso Coy, P. |
author_sort |
Avilés, M. |
title |
Oviductal secretions Will they be key factors for the future ARTs? |
title_short |
Oviductal secretions Will they be key factors for the future ARTs? |
title_full |
Oviductal secretions Will they be key factors for the future ARTs? |
title_fullStr |
Oviductal secretions Will they be key factors for the future ARTs? |
title_full_unstemmed |
Oviductal secretions Will they be key factors for the future ARTs? |
title_sort |
oviductal secretions will they be key factors for the future arts? |
publisher |
Oxford University Press |
publishDate |
2010 |
url |
http://hdl.handle.net/20.500.12792/2308 http://hdl.handle.net/10261/293253 |
work_keys_str_mv |
AT avilesm oviductalsecretionswilltheybekeyfactorsforthefuturearts AT gutierrezadanalfonso oviductalsecretionswilltheybekeyfactorsforthefuturearts AT coyp oviductalsecretionswilltheybekeyfactorsforthefuturearts |
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