Fine mapping of genes on sheep chromosome 1 and their association with milk traits
On the basis of comparative mapping between cattle/sheep and human for milk trait quantitative trait loci (QTL) on BTA3/OAR1, annexin A9 (ANXA9) and solute carrier family 27 (fatty acid transporter), member 3 (SLC27A3) were selected as candidate genes for fat content (FC) in sheep milk. Two other genes in the same region, cingulin (CGN) and acid phosphatase 6, lysophosphatidic (ACP6), were also considered. DNA fragments of 1931 and 2790 bp corresponding to ANXA9 and SLC27A3 respectively were isolated, and 14 and 6 single nucleotide polymorphisms (SNPs) respectively were found in each gene. ANXA9, SLC27A3, CGN and ACP6 were localized to chromosome 1 between INRA006 and AE57 by linkage mapping using the International Mapping Flock. Across-family analyses of a daughter design comprising 13 sire families revealed significant sire and SLC27A3 genotype-nested-within-sire effects for FC. Within-family analyses indicated significant regression coefficients for FC in four of six heterozygous sires. These results could reflect the existence of a QTL for FC linked to SLC27A3 in sheep. © 2006 International Society for Animal Genetics.
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Format: | artículo biblioteca |
Language: | English |
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Wiley
2006
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Subjects: | Dairy, Quantitative trait loci, Ovine chromosome 1, SLC27A3, ANXA9, CGN, ACP6, |
Online Access: | http://hdl.handle.net/20.500.12792/4934 http://hdl.handle.net/10261/293133 |
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dig-inia-es-10261-2931332023-02-20T07:36:17Z Fine mapping of genes on sheep chromosome 1 and their association with milk traits Calvo, J. H. Martínez-Royo, A. Beattie, A. E. Dodds, K. G. Marcos-Carcavilla, A. Serrano Noreña, Magdalena Dairy Quantitative trait loci Ovine chromosome 1 SLC27A3 ANXA9 CGN ACP6 On the basis of comparative mapping between cattle/sheep and human for milk trait quantitative trait loci (QTL) on BTA3/OAR1, annexin A9 (ANXA9) and solute carrier family 27 (fatty acid transporter), member 3 (SLC27A3) were selected as candidate genes for fat content (FC) in sheep milk. Two other genes in the same region, cingulin (CGN) and acid phosphatase 6, lysophosphatidic (ACP6), were also considered. DNA fragments of 1931 and 2790 bp corresponding to ANXA9 and SLC27A3 respectively were isolated, and 14 and 6 single nucleotide polymorphisms (SNPs) respectively were found in each gene. ANXA9, SLC27A3, CGN and ACP6 were localized to chromosome 1 between INRA006 and AE57 by linkage mapping using the International Mapping Flock. Across-family analyses of a daughter design comprising 13 sire families revealed significant sire and SLC27A3 genotype-nested-within-sire effects for FC. Within-family analyses indicated significant regression coefficients for FC in four of six heterozygous sires. These results could reflect the existence of a QTL for FC linked to SLC27A3 in sheep. © 2006 International Society for Animal Genetics. 2023-02-20T07:36:17Z 2023-02-20T07:36:17Z 2006 artículo Animal Genetics 37(3): 205-210 (2006) 0268-9146 http://hdl.handle.net/20.500.12792/4934 http://hdl.handle.net/10261/293133 10.1111/j.1365-2052.2006.01412.x 1365-2052 en none Wiley |
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Dairy Quantitative trait loci Ovine chromosome 1 SLC27A3 ANXA9 CGN ACP6 Dairy Quantitative trait loci Ovine chromosome 1 SLC27A3 ANXA9 CGN ACP6 |
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Dairy Quantitative trait loci Ovine chromosome 1 SLC27A3 ANXA9 CGN ACP6 Dairy Quantitative trait loci Ovine chromosome 1 SLC27A3 ANXA9 CGN ACP6 Calvo, J. H. Martínez-Royo, A. Beattie, A. E. Dodds, K. G. Marcos-Carcavilla, A. Serrano Noreña, Magdalena Fine mapping of genes on sheep chromosome 1 and their association with milk traits |
description |
On the basis of comparative mapping between cattle/sheep and human for milk trait quantitative trait loci (QTL) on BTA3/OAR1, annexin A9 (ANXA9) and solute carrier family 27 (fatty acid transporter), member 3 (SLC27A3) were selected as candidate genes for fat content (FC) in sheep milk. Two other genes in the same region, cingulin (CGN) and acid phosphatase 6, lysophosphatidic (ACP6), were also considered. DNA fragments of 1931 and 2790 bp corresponding to ANXA9 and SLC27A3 respectively were isolated, and 14 and 6 single nucleotide polymorphisms (SNPs) respectively were found in each gene. ANXA9, SLC27A3, CGN and ACP6 were localized to chromosome 1 between INRA006 and AE57 by linkage mapping using the International Mapping Flock. Across-family analyses of a daughter design comprising 13 sire families revealed significant sire and SLC27A3 genotype-nested-within-sire effects for FC. Within-family analyses indicated significant regression coefficients for FC in four of six heterozygous sires. These results could reflect the existence of a QTL for FC linked to SLC27A3 in sheep. © 2006 International Society for Animal Genetics. |
format |
artículo |
topic_facet |
Dairy Quantitative trait loci Ovine chromosome 1 SLC27A3 ANXA9 CGN ACP6 |
author |
Calvo, J. H. Martínez-Royo, A. Beattie, A. E. Dodds, K. G. Marcos-Carcavilla, A. Serrano Noreña, Magdalena |
author_facet |
Calvo, J. H. Martínez-Royo, A. Beattie, A. E. Dodds, K. G. Marcos-Carcavilla, A. Serrano Noreña, Magdalena |
author_sort |
Calvo, J. H. |
title |
Fine mapping of genes on sheep chromosome 1 and their association with milk traits |
title_short |
Fine mapping of genes on sheep chromosome 1 and their association with milk traits |
title_full |
Fine mapping of genes on sheep chromosome 1 and their association with milk traits |
title_fullStr |
Fine mapping of genes on sheep chromosome 1 and their association with milk traits |
title_full_unstemmed |
Fine mapping of genes on sheep chromosome 1 and their association with milk traits |
title_sort |
fine mapping of genes on sheep chromosome 1 and their association with milk traits |
publisher |
Wiley |
publishDate |
2006 |
url |
http://hdl.handle.net/20.500.12792/4934 http://hdl.handle.net/10261/293133 |
work_keys_str_mv |
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_version_ |
1767603438340800512 |