A QTL on pig chromosome 4 affects fatty acid metabolism Evidence from an Iberian by Landrace intercross
Three Iberian boars were bred to 31 Landrace sows to produce 79 F1 pigs. Six F1 boars were mated to 73 F1 sows. The F2 progeny from 33 full-sib families (250 individuals) were genotyped for seven microsatellites spanning the length of chromosome 4. Least squares procedures for interval mapping were used to detect quantitative trait loci (QTL). A permutation test was used to establish nominal significance levels associated with QTL effects, and resulting probability levels were corrected to a genomewide basis. Observed QTL effects were (genomewide significance, position of maximum significance in centimorgans) percentage of linoleic acid in subcutaneous adipose tissue (< 0.01, 81); backfat thickness (< 0.01, 83); backfat weight (< 0.01, 80); longissimus muscle area (0.02, 83); live weight (0.19, 88); and percentage of oleic acid in subcutaneous adipose tissue (0.25, 81). Gene action was primarily additive. The Iberian genotypes were fatter, slower growing, and had lower linoleic and higher oleic acid contents than Landrace genotypes. The interval from 80 to 83 cM contains the FAT1 and A-FABP loci that have been shown previously to affect fat deposition in pigs. This is the first report of a QTL affecting fatty acid composition of subcutaneous adipose tissue in pigs and provides a guide for the metabolic pathways affected by candidate genes described in this region of chromosome 4.
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Format: | artículo biblioteca |
Language: | English |
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Oxford University Press
2000
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Subjects: | Fat, Fatty Acids, Landrace, Pig Breeds, Quantitative Trait Loci, |
Online Access: | http://hdl.handle.net/20.500.12792/3443 http://hdl.handle.net/10261/293123 |
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dig-inia-es-10261-2931232023-02-20T07:36:10Z A QTL on pig chromosome 4 affects fatty acid metabolism Evidence from an Iberian by Landrace intercross Pérez-Enciso, M. Clop, A. Noguera, J. L. Óvilo Martín, Cristina Coll, A. Folch, J. M. Babot, D. Estany, J. Oliver, M. A. Díaz, I. Sánchez, A. Fat Fatty Acids Landrace Pig Breeds Quantitative Trait Loci Three Iberian boars were bred to 31 Landrace sows to produce 79 F1 pigs. Six F1 boars were mated to 73 F1 sows. The F2 progeny from 33 full-sib families (250 individuals) were genotyped for seven microsatellites spanning the length of chromosome 4. Least squares procedures for interval mapping were used to detect quantitative trait loci (QTL). A permutation test was used to establish nominal significance levels associated with QTL effects, and resulting probability levels were corrected to a genomewide basis. Observed QTL effects were (genomewide significance, position of maximum significance in centimorgans) percentage of linoleic acid in subcutaneous adipose tissue (< 0.01, 81); backfat thickness (< 0.01, 83); backfat weight (< 0.01, 80); longissimus muscle area (0.02, 83); live weight (0.19, 88); and percentage of oleic acid in subcutaneous adipose tissue (0.25, 81). Gene action was primarily additive. The Iberian genotypes were fatter, slower growing, and had lower linoleic and higher oleic acid contents than Landrace genotypes. The interval from 80 to 83 cM contains the FAT1 and A-FABP loci that have been shown previously to affect fat deposition in pigs. This is the first report of a QTL affecting fatty acid composition of subcutaneous adipose tissue in pigs and provides a guide for the metabolic pathways affected by candidate genes described in this region of chromosome 4. 2023-02-20T07:36:10Z 2023-02-20T07:36:10Z 2000 artículo Journal of Animal Science 78(10): 2525-2531 (2000) 0021-8812 http://hdl.handle.net/20.500.12792/3443 http://hdl.handle.net/10261/293123 10.2527/2000.78102525x 1525-3163 en none Oxford University Press |
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Fat Fatty Acids Landrace Pig Breeds Quantitative Trait Loci Fat Fatty Acids Landrace Pig Breeds Quantitative Trait Loci |
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Fat Fatty Acids Landrace Pig Breeds Quantitative Trait Loci Fat Fatty Acids Landrace Pig Breeds Quantitative Trait Loci Pérez-Enciso, M. Clop, A. Noguera, J. L. Óvilo Martín, Cristina Coll, A. Folch, J. M. Babot, D. Estany, J. Oliver, M. A. Díaz, I. Sánchez, A. A QTL on pig chromosome 4 affects fatty acid metabolism Evidence from an Iberian by Landrace intercross |
description |
Three Iberian boars were bred to 31 Landrace sows to produce 79 F1 pigs. Six F1 boars were mated to 73 F1 sows. The F2 progeny from 33 full-sib families (250 individuals) were genotyped for seven microsatellites spanning the length of chromosome 4. Least squares procedures for interval mapping were used to detect quantitative trait loci (QTL). A permutation test was used to establish nominal significance levels associated with QTL effects, and resulting probability levels were corrected to a genomewide basis. Observed QTL effects were (genomewide significance, position of maximum significance in centimorgans) percentage of linoleic acid in subcutaneous adipose tissue (< 0.01, 81); backfat thickness (< 0.01, 83); backfat weight (< 0.01, 80); longissimus muscle area (0.02, 83); live weight (0.19, 88); and percentage of oleic acid in subcutaneous adipose tissue (0.25, 81). Gene action was primarily additive. The Iberian genotypes were fatter, slower growing, and had lower linoleic and higher oleic acid contents than Landrace genotypes. The interval from 80 to 83 cM contains the FAT1 and A-FABP loci that have been shown previously to affect fat deposition in pigs. This is the first report of a QTL affecting fatty acid composition of subcutaneous adipose tissue in pigs and provides a guide for the metabolic pathways affected by candidate genes described in this region of chromosome 4. |
format |
artículo |
topic_facet |
Fat Fatty Acids Landrace Pig Breeds Quantitative Trait Loci |
author |
Pérez-Enciso, M. Clop, A. Noguera, J. L. Óvilo Martín, Cristina Coll, A. Folch, J. M. Babot, D. Estany, J. Oliver, M. A. Díaz, I. Sánchez, A. |
author_facet |
Pérez-Enciso, M. Clop, A. Noguera, J. L. Óvilo Martín, Cristina Coll, A. Folch, J. M. Babot, D. Estany, J. Oliver, M. A. Díaz, I. Sánchez, A. |
author_sort |
Pérez-Enciso, M. |
title |
A QTL on pig chromosome 4 affects fatty acid metabolism Evidence from an Iberian by Landrace intercross |
title_short |
A QTL on pig chromosome 4 affects fatty acid metabolism Evidence from an Iberian by Landrace intercross |
title_full |
A QTL on pig chromosome 4 affects fatty acid metabolism Evidence from an Iberian by Landrace intercross |
title_fullStr |
A QTL on pig chromosome 4 affects fatty acid metabolism Evidence from an Iberian by Landrace intercross |
title_full_unstemmed |
A QTL on pig chromosome 4 affects fatty acid metabolism Evidence from an Iberian by Landrace intercross |
title_sort |
qtl on pig chromosome 4 affects fatty acid metabolism evidence from an iberian by landrace intercross |
publisher |
Oxford University Press |
publishDate |
2000 |
url |
http://hdl.handle.net/20.500.12792/3443 http://hdl.handle.net/10261/293123 |
work_keys_str_mv |
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