Exploring alternative models for sex-linked quantitative trait loci in outbred populations Application to an Iberian × Landrace pig intercross
We present a very flexible method that allows us to analyze X-linked quantitative trait loci (QTL) in crosses between outbred-lines. The dosage compensation phenomenon is modeled explicitly in an identity-by-descent approach. A variety of models can be fitted, ranging from considering alternative fixed alleles within the founder breeds to a model where the only genetic variation is within breeds, as well as mixed models. Different genetic variances within each founder breed can be estimated. We illustrate the method with data from an F2 cross between Iberian × Landrace pigs for intramuscular fat content and meat color component a*. The Iberian allele exhibited a strong overdominant effect for intramuscular fat in females. There was also limited evidence of one or more regions affecting color component a*. The analysis suggested that the QTL alleles were fixed in the Iberian founders, whereas there was some evidence of segregation in Landrace for the QTL affecting a* color component.
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Oxford University Press
2002
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Online Access: | http://hdl.handle.net/20.500.12792/3442 http://hdl.handle.net/10261/293114 |
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dig-inia-es-10261-2931142023-02-20T07:35:54Z Exploring alternative models for sex-linked quantitative trait loci in outbred populations Application to an Iberian × Landrace pig intercross Pérez-Enciso, M. Clop, A. Folch, J. M. Sánchez, A. Oliver, M. A. Óvilo Martín, Cristina Barragán, C. Varona, L. Noguera, J. L. We present a very flexible method that allows us to analyze X-linked quantitative trait loci (QTL) in crosses between outbred-lines. The dosage compensation phenomenon is modeled explicitly in an identity-by-descent approach. A variety of models can be fitted, ranging from considering alternative fixed alleles within the founder breeds to a model where the only genetic variation is within breeds, as well as mixed models. Different genetic variances within each founder breed can be estimated. We illustrate the method with data from an F2 cross between Iberian × Landrace pigs for intramuscular fat content and meat color component a*. The Iberian allele exhibited a strong overdominant effect for intramuscular fat in females. There was also limited evidence of one or more regions affecting color component a*. The analysis suggested that the QTL alleles were fixed in the Iberian founders, whereas there was some evidence of segregation in Landrace for the QTL affecting a* color component. 2023-02-20T07:35:54Z 2023-02-20T07:35:54Z 2002 artículo Genetics 161(4): 1625-1632 (2002) 0016-6731 http://hdl.handle.net/20.500.12792/3442 http://hdl.handle.net/10261/293114 1943-2631 en none Oxford University Press |
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We present a very flexible method that allows us to analyze X-linked quantitative trait loci (QTL) in crosses between outbred-lines. The dosage compensation phenomenon is modeled explicitly in an identity-by-descent approach. A variety of models can be fitted, ranging from considering alternative fixed alleles within the founder breeds to a model where the only genetic variation is within breeds, as well as mixed models. Different genetic variances within each founder breed can be estimated. We illustrate the method with data from an F2 cross between Iberian × Landrace pigs for intramuscular fat content and meat color component a*. The Iberian allele exhibited a strong overdominant effect for intramuscular fat in females. There was also limited evidence of one or more regions affecting color component a*. The analysis suggested that the QTL alleles were fixed in the Iberian founders, whereas there was some evidence of segregation in Landrace for the QTL affecting a* color component. |
format |
artículo |
author |
Pérez-Enciso, M. Clop, A. Folch, J. M. Sánchez, A. Oliver, M. A. Óvilo Martín, Cristina Barragán, C. Varona, L. Noguera, J. L. |
spellingShingle |
Pérez-Enciso, M. Clop, A. Folch, J. M. Sánchez, A. Oliver, M. A. Óvilo Martín, Cristina Barragán, C. Varona, L. Noguera, J. L. Exploring alternative models for sex-linked quantitative trait loci in outbred populations Application to an Iberian × Landrace pig intercross |
author_facet |
Pérez-Enciso, M. Clop, A. Folch, J. M. Sánchez, A. Oliver, M. A. Óvilo Martín, Cristina Barragán, C. Varona, L. Noguera, J. L. |
author_sort |
Pérez-Enciso, M. |
title |
Exploring alternative models for sex-linked quantitative trait loci in outbred populations Application to an Iberian × Landrace pig intercross |
title_short |
Exploring alternative models for sex-linked quantitative trait loci in outbred populations Application to an Iberian × Landrace pig intercross |
title_full |
Exploring alternative models for sex-linked quantitative trait loci in outbred populations Application to an Iberian × Landrace pig intercross |
title_fullStr |
Exploring alternative models for sex-linked quantitative trait loci in outbred populations Application to an Iberian × Landrace pig intercross |
title_full_unstemmed |
Exploring alternative models for sex-linked quantitative trait loci in outbred populations Application to an Iberian × Landrace pig intercross |
title_sort |
exploring alternative models for sex-linked quantitative trait loci in outbred populations application to an iberian × landrace pig intercross |
publisher |
Oxford University Press |
publishDate |
2002 |
url |
http://hdl.handle.net/20.500.12792/3442 http://hdl.handle.net/10261/293114 |
work_keys_str_mv |
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