Immunosuppression during acute infection with foot-and-mouth disease virus in swine is mediated by IL-10
Foot-and-mouth disease virus (FMDV) is one of the most contagious animal viruses, causing a devastating disease in cloven-hoofed animals with enormous economic consequences. Identification of the different parameters involved in the immune response elicited against FMDV remains unclear, and it is fundamental the understanding of such parameters before effective control measures can be put in place. In the present study, we show that interleukin-10 (IL-10) production by dendritic cells (DCs) is drastically increased during acute infection with FMDV in swine. In vitro blockade of IL-10 with a neutralizing antibody against porcine IL-10 restores T cell activation by DCs. Additionally, we describe that FMDV infects DC precursors and interferes with DC maturation and antigen presentation capacity. Thus, we propose a new mechanism of virus immunity in which a non-persistent virus, FMDV, induces immunosuppression by an increment in the production of IL-10, which in turn, reduces T cell function. This reduction of T cell activity may result in a more potent induction of neutralizing antibody responses, clearing the viral infection. © 2009 Díaz-San Segundo et al.
Main Authors: | Díaz-San Segundo, F., Rodríguez-Calvo, T., de Avila, A., Sevilla Hidalgo, Noemi |
---|---|
Format: | artículo biblioteca |
Language: | English |
Published: |
Public Library of Science
2009
|
Online Access: | http://hdl.handle.net/20.500.12792/1089 http://hdl.handle.net/10261/293068 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Immunosuppression during acute infection with foot-and-mouth disease virus in swine is mediated by IL-10
by: Díaz-San Segundo, F., et al.
Published: (2009) -
Selective lymphocyte depletion during the early stage of the immune response to foot-and-mouth disease virus infection in swine
by: Díaz-San Segundo, F., et al.
Published: (2006) -
Selective lymphocyte depletion during the early stage of the immune response to foot-and-mouth disease virus infection in swine
by: Díaz-San Segundo, F., et al.
Published: (2006) -
A replication analysis of foot-and-mouth disease virus in swine lymphoid tissue might indicate a putative carrier stage in pigs
by: Rodríguez-Calvo, T., et al.
Published: (2011) -
Comprehensive immune profiling reveals that Orbivirus infection activates immune checkpoints during acute T cell immunosuppression
by: Louloudes-Lázaro, Andrés, et al.
Published: (2023-10-18)