Contribution of large animals to translational research on prenatal programming of obesity and associated diseases
Background The awareness of factors causing obesity and associated disorders has grown up in the last years from genome to a more complicated concept (developmental programming) in which prenatal and early-postnatal conditions markedly modify the phenotype and homeostasis of the individuals and determine juvenile growth, life-time fitness/obesity and disease risks. Method Experimentation in human beings is impeded by ethical issues plus inherent high variability and confounding factors (genetics, lifestyle and socioeconomic heterogeneity) and preclinical studies in adequate translational animal models are therefore decisive. Most of the studies have been performed in rodents, whilst the use of large animals is scarce. Having in mind body-size, handlingeasiness and cost-efficiency, the main large animal species for use in biomedical research are rabbits, sheep and swine. The choice of the model depends on the research objectives. Aims To outline the main features of the use of rabbits, sheep and swine and their contributions as translational models in prenatal programming of obesity and associated disorders. © 2017 Bentham Science Publishers.
Main Authors: | , |
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Format: | artículo de revisión biblioteca |
Language: | English |
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Bentham Science Publishers
2017
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Subjects: | Animal-models, Obesity, Prenatal-programming, Rabbit, Sheep, Swine, Translational-medicine, |
Online Access: | http://hdl.handle.net/20.500.12792/1898 http://hdl.handle.net/10261/292863 |
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dig-inia-es-10261-2928632023-02-20T07:33:13Z Contribution of large animals to translational research on prenatal programming of obesity and associated diseases González De Bulnes, Antonio Chavatte-Palmer, P. Animal-models Obesity Prenatal-programming Rabbit Sheep Swine Translational-medicine Background The awareness of factors causing obesity and associated disorders has grown up in the last years from genome to a more complicated concept (developmental programming) in which prenatal and early-postnatal conditions markedly modify the phenotype and homeostasis of the individuals and determine juvenile growth, life-time fitness/obesity and disease risks. Method Experimentation in human beings is impeded by ethical issues plus inherent high variability and confounding factors (genetics, lifestyle and socioeconomic heterogeneity) and preclinical studies in adequate translational animal models are therefore decisive. Most of the studies have been performed in rodents, whilst the use of large animals is scarce. Having in mind body-size, handlingeasiness and cost-efficiency, the main large animal species for use in biomedical research are rabbits, sheep and swine. The choice of the model depends on the research objectives. Aims To outline the main features of the use of rabbits, sheep and swine and their contributions as translational models in prenatal programming of obesity and associated disorders. © 2017 Bentham Science Publishers. 2023-02-20T07:33:13Z 2023-02-20T07:33:13Z 2017 artículo de revisión Current Pharmaceutical Biotechnology 18(7): 541-551 (2017) 1389-2010 http://hdl.handle.net/20.500.12792/1898 http://hdl.handle.net/10261/292863 10.2174/1389201018666170811150920 1873-4316 en none Bentham Science Publishers |
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Animal-models Obesity Prenatal-programming Rabbit Sheep Swine Translational-medicine Animal-models Obesity Prenatal-programming Rabbit Sheep Swine Translational-medicine González De Bulnes, Antonio Chavatte-Palmer, P. Contribution of large animals to translational research on prenatal programming of obesity and associated diseases |
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Background The awareness of factors causing obesity and associated disorders has grown up in the last years from genome to a more complicated concept (developmental programming) in which prenatal and early-postnatal conditions markedly modify the phenotype and homeostasis of the individuals and determine juvenile growth, life-time fitness/obesity and disease risks. Method Experimentation in human beings is impeded by ethical issues plus inherent high variability and confounding factors (genetics, lifestyle and socioeconomic heterogeneity) and preclinical studies in adequate translational animal models are therefore decisive. Most of the studies have been performed in rodents, whilst the use of large animals is scarce. Having in mind body-size, handlingeasiness and cost-efficiency, the main large animal species for use in biomedical research are rabbits, sheep and swine. The choice of the model depends on the research objectives. Aims To outline the main features of the use of rabbits, sheep and swine and their contributions as translational models in prenatal programming of obesity and associated disorders. © 2017 Bentham Science Publishers. |
format |
artículo de revisión |
topic_facet |
Animal-models Obesity Prenatal-programming Rabbit Sheep Swine Translational-medicine |
author |
González De Bulnes, Antonio Chavatte-Palmer, P. |
author_facet |
González De Bulnes, Antonio Chavatte-Palmer, P. |
author_sort |
González De Bulnes, Antonio |
title |
Contribution of large animals to translational research on prenatal programming of obesity and associated diseases |
title_short |
Contribution of large animals to translational research on prenatal programming of obesity and associated diseases |
title_full |
Contribution of large animals to translational research on prenatal programming of obesity and associated diseases |
title_fullStr |
Contribution of large animals to translational research on prenatal programming of obesity and associated diseases |
title_full_unstemmed |
Contribution of large animals to translational research on prenatal programming of obesity and associated diseases |
title_sort |
contribution of large animals to translational research on prenatal programming of obesity and associated diseases |
publisher |
Bentham Science Publishers |
publishDate |
2017 |
url |
http://hdl.handle.net/20.500.12792/1898 http://hdl.handle.net/10261/292863 |
work_keys_str_mv |
AT gonzalezdebulnesantonio contributionoflargeanimalstotranslationalresearchonprenatalprogrammingofobesityandassociateddiseases AT chavattepalmerp contributionoflargeanimalstotranslationalresearchonprenatalprogrammingofobesityandassociateddiseases |
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1767603402086285312 |