Transgenerational inheritance in the offspring of pregnant women with metabolic syndrome
Currently, it is well-known that changes in the maternal metabolic status induce changes in the intrauterine environment and modify the metabolic status of the fetuses, playing a key role in the growth, life-time fitness/obesity and probability of appearance of metabolic disorders in the offspring. There is increasing evidence that these effects may not be only limited to the first generation of descendants, the offspring directly exposed to metabolic challenges, but to subsequent generations either exposed (multigenerational exposure) or unexposed (intergenerational or transgenerational inheritance) to such metabolic defies, perpetuating the problem. Thus, having in mind the impact on worldwide public health, the present review outlines, based on results of translational animal research and clinical human studies, the mechanisms, pathways and practical implications involved in the transgenerational inheritance of the metabolic syndrome. © 2014 Bentham Science Publishers.
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Format: | artículo de revisión biblioteca |
Language: | English |
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Bentham Science Publishers
2014
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Subjects: | Developmental-programming, Epigenetics, Fetal-hypoxia, Fetal-metabolism, Metabolic-syndrome, Placentalefficiency, Transgenerational-programming, |
Online Access: | http://hdl.handle.net/20.500.12792/1909 http://hdl.handle.net/10261/292437 |
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dig-inia-es-10261-2924372023-02-20T07:28:56Z Transgenerational inheritance in the offspring of pregnant women with metabolic syndrome González De Bulnes, Antonio Óvilo Martín, Cristina Astiz Blanco, Susana María Developmental-programming Epigenetics Fetal-hypoxia Fetal-metabolism Metabolic-syndrome Placentalefficiency Transgenerational-programming Currently, it is well-known that changes in the maternal metabolic status induce changes in the intrauterine environment and modify the metabolic status of the fetuses, playing a key role in the growth, life-time fitness/obesity and probability of appearance of metabolic disorders in the offspring. There is increasing evidence that these effects may not be only limited to the first generation of descendants, the offspring directly exposed to metabolic challenges, but to subsequent generations either exposed (multigenerational exposure) or unexposed (intergenerational or transgenerational inheritance) to such metabolic defies, perpetuating the problem. Thus, having in mind the impact on worldwide public health, the present review outlines, based on results of translational animal research and clinical human studies, the mechanisms, pathways and practical implications involved in the transgenerational inheritance of the metabolic syndrome. © 2014 Bentham Science Publishers. 2023-02-20T07:28:56Z 2023-02-20T07:28:56Z 2014 artículo de revisión Current Pharmaceutical Biotechnology 15(1): 13-23 (2014) 1389-2010 http://hdl.handle.net/20.500.12792/1909 http://hdl.handle.net/10261/292437 10.2174/1389201015666140330192009 1873-4316 en none Bentham Science Publishers |
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Developmental-programming Epigenetics Fetal-hypoxia Fetal-metabolism Metabolic-syndrome Placentalefficiency Transgenerational-programming Developmental-programming Epigenetics Fetal-hypoxia Fetal-metabolism Metabolic-syndrome Placentalefficiency Transgenerational-programming |
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Developmental-programming Epigenetics Fetal-hypoxia Fetal-metabolism Metabolic-syndrome Placentalefficiency Transgenerational-programming Developmental-programming Epigenetics Fetal-hypoxia Fetal-metabolism Metabolic-syndrome Placentalefficiency Transgenerational-programming González De Bulnes, Antonio Óvilo Martín, Cristina Astiz Blanco, Susana María Transgenerational inheritance in the offspring of pregnant women with metabolic syndrome |
description |
Currently, it is well-known that changes in the maternal metabolic status induce changes in the intrauterine environment and modify the metabolic status of the fetuses, playing a key role in the growth, life-time fitness/obesity and probability of appearance of metabolic disorders in the offspring. There is increasing evidence that these effects may not be only limited to the first generation of descendants, the offspring directly exposed to metabolic challenges, but to subsequent generations either exposed (multigenerational exposure) or unexposed (intergenerational or transgenerational inheritance) to such metabolic defies, perpetuating the problem. Thus, having in mind the impact on worldwide public health, the present review outlines, based on results of translational animal research and clinical human studies, the mechanisms, pathways and practical implications involved in the transgenerational inheritance of the metabolic syndrome. © 2014 Bentham Science Publishers. |
format |
artículo de revisión |
topic_facet |
Developmental-programming Epigenetics Fetal-hypoxia Fetal-metabolism Metabolic-syndrome Placentalefficiency Transgenerational-programming |
author |
González De Bulnes, Antonio Óvilo Martín, Cristina Astiz Blanco, Susana María |
author_facet |
González De Bulnes, Antonio Óvilo Martín, Cristina Astiz Blanco, Susana María |
author_sort |
González De Bulnes, Antonio |
title |
Transgenerational inheritance in the offspring of pregnant women with metabolic syndrome |
title_short |
Transgenerational inheritance in the offspring of pregnant women with metabolic syndrome |
title_full |
Transgenerational inheritance in the offspring of pregnant women with metabolic syndrome |
title_fullStr |
Transgenerational inheritance in the offspring of pregnant women with metabolic syndrome |
title_full_unstemmed |
Transgenerational inheritance in the offspring of pregnant women with metabolic syndrome |
title_sort |
transgenerational inheritance in the offspring of pregnant women with metabolic syndrome |
publisher |
Bentham Science Publishers |
publishDate |
2014 |
url |
http://hdl.handle.net/20.500.12792/1909 http://hdl.handle.net/10261/292437 |
work_keys_str_mv |
AT gonzalezdebulnesantonio transgenerationalinheritanceintheoffspringofpregnantwomenwithmetabolicsyndrome AT ovilomartincristina transgenerationalinheritanceintheoffspringofpregnantwomenwithmetabolicsyndrome AT astizblancosusanamaria transgenerationalinheritanceintheoffspringofpregnantwomenwithmetabolicsyndrome |
_version_ |
1767603345041653760 |