Toxicokinetics of perfluorooctane sulfonate in birds under environmentally realistic exposure conditions and development of a kinetic predictive model
This article describes the toxicokinetics of perfluorooctane sulfonate (PFOS) in birds under low repeated dosing, equivalent to 0.085. μg/kg per day, representing environmentally realistic exposure conditions. The best fitting was provided by a simple pseudo monocompartmental first-order kinetics model, regulated by two rates, with a pseudo first-order dissipation half-life of 230 days, accounting for real elimination as well as binding of PFOS to non-exchangeable structures. The calculated assimilation efficiency was 0.66 with confidence intervals of 0.64 and 0.68. The model calculations confirmed that the measured maximum concentrations were still far from the steady state situation, which for this dose regime, was estimated at a value of about 65. μg PFOS/L serum achieved after a theoretical 210 weeks continuous exposure. The results confirm a very different kinetics than that observed in single-dose experiments confirming clear dose-related differences in apparent elimination rates in birds, as described for humans and monkeys; suggesting that a capacity-limited saturable process should also be considered in the kinetic behavior of PFOS in birds. Pseudo first-order kinetic models are highly convenient and frequently used for predicting bioaccumulation of chemicals in livestock and wildlife; the study suggests that previous bioaccumulation models using half-lives obtained at high doses are expected to underestimate the biomagnification potential of PFOS. The toxicokinetic parameters presented here can be used for higher-tier bioaccumulation estimations of PFOS in chickens and as surrogate values for modeling PFOS kinetics in wild bird species. © 2014 Elsevier Ireland Ltd.
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| Format: | artículo biblioteca |
| Language: | English |
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Elsevier
2015
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| Subjects: | PFOS, Toxicokinetics, Elimination half-life, Birds, Gallus gallus, |
| Online Access: | http://hdl.handle.net/20.500.12792/5511 http://hdl.handle.net/10261/292310 |
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dig-inia-es-10261-2923102023-02-20T07:27:39Z Toxicokinetics of perfluorooctane sulfonate in birds under environmentally realistic exposure conditions and development of a kinetic predictive model Tarazona, J. V. Rodríguez, C. Alonso, E. Sáez, M. González, F. San Andrés, M. D. Jiménez, B. San Andrés, M. I. PFOS Toxicokinetics Elimination half-life Birds Gallus gallus This article describes the toxicokinetics of perfluorooctane sulfonate (PFOS) in birds under low repeated dosing, equivalent to 0.085. μg/kg per day, representing environmentally realistic exposure conditions. The best fitting was provided by a simple pseudo monocompartmental first-order kinetics model, regulated by two rates, with a pseudo first-order dissipation half-life of 230 days, accounting for real elimination as well as binding of PFOS to non-exchangeable structures. The calculated assimilation efficiency was 0.66 with confidence intervals of 0.64 and 0.68. The model calculations confirmed that the measured maximum concentrations were still far from the steady state situation, which for this dose regime, was estimated at a value of about 65. μg PFOS/L serum achieved after a theoretical 210 weeks continuous exposure. The results confirm a very different kinetics than that observed in single-dose experiments confirming clear dose-related differences in apparent elimination rates in birds, as described for humans and monkeys; suggesting that a capacity-limited saturable process should also be considered in the kinetic behavior of PFOS in birds. Pseudo first-order kinetic models are highly convenient and frequently used for predicting bioaccumulation of chemicals in livestock and wildlife; the study suggests that previous bioaccumulation models using half-lives obtained at high doses are expected to underestimate the biomagnification potential of PFOS. The toxicokinetic parameters presented here can be used for higher-tier bioaccumulation estimations of PFOS in chickens and as surrogate values for modeling PFOS kinetics in wild bird species. © 2014 Elsevier Ireland Ltd. 2023-02-20T07:27:39Z 2023-02-20T07:27:39Z 2015 artículo Toxicology Letters 232(2): 363-3638 (2015) 0378-4274 http://hdl.handle.net/20.500.12792/5511 http://hdl.handle.net/10261/292310 10.1016/j.toxlet.2014.11.022 en none Elsevier |
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PFOS Toxicokinetics Elimination half-life Birds Gallus gallus PFOS Toxicokinetics Elimination half-life Birds Gallus gallus |
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PFOS Toxicokinetics Elimination half-life Birds Gallus gallus PFOS Toxicokinetics Elimination half-life Birds Gallus gallus Tarazona, J. V. Rodríguez, C. Alonso, E. Sáez, M. González, F. San Andrés, M. D. Jiménez, B. San Andrés, M. I. Toxicokinetics of perfluorooctane sulfonate in birds under environmentally realistic exposure conditions and development of a kinetic predictive model |
| description |
This article describes the toxicokinetics of perfluorooctane sulfonate (PFOS) in birds under low repeated dosing, equivalent to 0.085. μg/kg per day, representing environmentally realistic exposure conditions. The best fitting was provided by a simple pseudo monocompartmental first-order kinetics model, regulated by two rates, with a pseudo first-order dissipation half-life of 230 days, accounting for real elimination as well as binding of PFOS to non-exchangeable structures. The calculated assimilation efficiency was 0.66 with confidence intervals of 0.64 and 0.68. The model calculations confirmed that the measured maximum concentrations were still far from the steady state situation, which for this dose regime, was estimated at a value of about 65. μg PFOS/L serum achieved after a theoretical 210 weeks continuous exposure. The results confirm a very different kinetics than that observed in single-dose experiments confirming clear dose-related differences in apparent elimination rates in birds, as described for humans and monkeys; suggesting that a capacity-limited saturable process should also be considered in the kinetic behavior of PFOS in birds. Pseudo first-order kinetic models are highly convenient and frequently used for predicting bioaccumulation of chemicals in livestock and wildlife; the study suggests that previous bioaccumulation models using half-lives obtained at high doses are expected to underestimate the biomagnification potential of PFOS. The toxicokinetic parameters presented here can be used for higher-tier bioaccumulation estimations of PFOS in chickens and as surrogate values for modeling PFOS kinetics in wild bird species. © 2014 Elsevier Ireland Ltd. |
| format |
artículo |
| topic_facet |
PFOS Toxicokinetics Elimination half-life Birds Gallus gallus |
| author |
Tarazona, J. V. Rodríguez, C. Alonso, E. Sáez, M. González, F. San Andrés, M. D. Jiménez, B. San Andrés, M. I. |
| author_facet |
Tarazona, J. V. Rodríguez, C. Alonso, E. Sáez, M. González, F. San Andrés, M. D. Jiménez, B. San Andrés, M. I. |
| author_sort |
Tarazona, J. V. |
| title |
Toxicokinetics of perfluorooctane sulfonate in birds under environmentally realistic exposure conditions and development of a kinetic predictive model |
| title_short |
Toxicokinetics of perfluorooctane sulfonate in birds under environmentally realistic exposure conditions and development of a kinetic predictive model |
| title_full |
Toxicokinetics of perfluorooctane sulfonate in birds under environmentally realistic exposure conditions and development of a kinetic predictive model |
| title_fullStr |
Toxicokinetics of perfluorooctane sulfonate in birds under environmentally realistic exposure conditions and development of a kinetic predictive model |
| title_full_unstemmed |
Toxicokinetics of perfluorooctane sulfonate in birds under environmentally realistic exposure conditions and development of a kinetic predictive model |
| title_sort |
toxicokinetics of perfluorooctane sulfonate in birds under environmentally realistic exposure conditions and development of a kinetic predictive model |
| publisher |
Elsevier |
| publishDate |
2015 |
| url |
http://hdl.handle.net/20.500.12792/5511 http://hdl.handle.net/10261/292310 |
| work_keys_str_mv |
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| _version_ |
1767603327601737728 |