Distribution of Bartonella henselae variants in patients, reservoir hosts and vectors in Spain
We have studied the diversity of B. henselae circulating in patients, reservoir hosts and vectors in Spain. In total, we have fully characterized 53 clinical samples from 46 patients, as well as 78 B. henselae isolates obtained from 35 cats from La Rioja and Catalonia (northeastern Spain), four positive cat blood samples from which no isolates were obtained, and three positive fleas by Multiple Locus Sequence Typing and Multiple Locus Variable Number Tandem Repeats Analysis. This study represents the largest series of human cases characterized with these methods, with 10 different sequence types and 41 MLVA profiles. Two of the sequence types and 35 of the profiles were not described previously. Most of the B. henselae variants belonged to ST5. Also, we have identified a common profile (72) which is well distributed in Spain and was found to persist over time. Indeed, this profile seems to be the origin from which most of the variants identified in this study have been generated. In addition, ST5, ST6 and ST9 were found associated with felines, whereas ST1, ST5 and ST8 were the most frequent sequence types found infecting humans. Interestingly, some of the feline associated variants never found on patients were located in a separate clade, which could represent a group of strains less pathogenic for humans. © 2013 Gil et al.
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dig-inia-es-10261-2922502023-02-20T07:27:02Z Distribution of Bartonella henselae variants in patients, reservoir hosts and vectors in Spain Gil, H. Escudero, R. Pons, I. Rodríguez-Vargas, M. García-Esteban, C. Rodríguez-Moreno, I. García-Amil, C. Lobo, B. Valcárcel Sancho, Félix María Pérez, A. Jiménez, S. Jado, I. Juste, R. Segura, F. Anda, P. We have studied the diversity of B. henselae circulating in patients, reservoir hosts and vectors in Spain. In total, we have fully characterized 53 clinical samples from 46 patients, as well as 78 B. henselae isolates obtained from 35 cats from La Rioja and Catalonia (northeastern Spain), four positive cat blood samples from which no isolates were obtained, and three positive fleas by Multiple Locus Sequence Typing and Multiple Locus Variable Number Tandem Repeats Analysis. This study represents the largest series of human cases characterized with these methods, with 10 different sequence types and 41 MLVA profiles. Two of the sequence types and 35 of the profiles were not described previously. Most of the B. henselae variants belonged to ST5. Also, we have identified a common profile (72) which is well distributed in Spain and was found to persist over time. Indeed, this profile seems to be the origin from which most of the variants identified in this study have been generated. In addition, ST5, ST6 and ST9 were found associated with felines, whereas ST1, ST5 and ST8 were the most frequent sequence types found infecting humans. Interestingly, some of the feline associated variants never found on patients were located in a separate clade, which could represent a group of strains less pathogenic for humans. © 2013 Gil et al. 2023-02-20T07:27:02Z 2023-02-20T07:27:02Z 2013 artículo PLoS ONE 8(7): e68248 (2013) http://hdl.handle.net/20.500.12792/1733 http://hdl.handle.net/10261/292250 10.1371/journal.pone.0068248 1932-6203 en open Public Library of Science |
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We have studied the diversity of B. henselae circulating in patients, reservoir hosts and vectors in Spain. In total, we have fully characterized 53 clinical samples from 46 patients, as well as 78 B. henselae isolates obtained from 35 cats from La Rioja and Catalonia (northeastern Spain), four positive cat blood samples from which no isolates were obtained, and three positive fleas by Multiple Locus Sequence Typing and Multiple Locus Variable Number Tandem Repeats Analysis. This study represents the largest series of human cases characterized with these methods, with 10 different sequence types and 41 MLVA profiles. Two of the sequence types and 35 of the profiles were not described previously. Most of the B. henselae variants belonged to ST5. Also, we have identified a common profile (72) which is well distributed in Spain and was found to persist over time. Indeed, this profile seems to be the origin from which most of the variants identified in this study have been generated. In addition, ST5, ST6 and ST9 were found associated with felines, whereas ST1, ST5 and ST8 were the most frequent sequence types found infecting humans. Interestingly, some of the feline associated variants never found on patients were located in a separate clade, which could represent a group of strains less pathogenic for humans. © 2013 Gil et al. |
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Gil, H. Escudero, R. Pons, I. Rodríguez-Vargas, M. García-Esteban, C. Rodríguez-Moreno, I. García-Amil, C. Lobo, B. Valcárcel Sancho, Félix María Pérez, A. Jiménez, S. Jado, I. Juste, R. Segura, F. Anda, P. |
spellingShingle |
Gil, H. Escudero, R. Pons, I. Rodríguez-Vargas, M. García-Esteban, C. Rodríguez-Moreno, I. García-Amil, C. Lobo, B. Valcárcel Sancho, Félix María Pérez, A. Jiménez, S. Jado, I. Juste, R. Segura, F. Anda, P. Distribution of Bartonella henselae variants in patients, reservoir hosts and vectors in Spain |
author_facet |
Gil, H. Escudero, R. Pons, I. Rodríguez-Vargas, M. García-Esteban, C. Rodríguez-Moreno, I. García-Amil, C. Lobo, B. Valcárcel Sancho, Félix María Pérez, A. Jiménez, S. Jado, I. Juste, R. Segura, F. Anda, P. |
author_sort |
Gil, H. |
title |
Distribution of Bartonella henselae variants in patients, reservoir hosts and vectors in Spain |
title_short |
Distribution of Bartonella henselae variants in patients, reservoir hosts and vectors in Spain |
title_full |
Distribution of Bartonella henselae variants in patients, reservoir hosts and vectors in Spain |
title_fullStr |
Distribution of Bartonella henselae variants in patients, reservoir hosts and vectors in Spain |
title_full_unstemmed |
Distribution of Bartonella henselae variants in patients, reservoir hosts and vectors in Spain |
title_sort |
distribution of bartonella henselae variants in patients, reservoir hosts and vectors in spain |
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Public Library of Science |
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2013 |
url |
http://hdl.handle.net/20.500.12792/1733 http://hdl.handle.net/10261/292250 |
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