Morphological and immunohistochemical changes in splenic macrophages of pigs infected with classical swine fever
Classical swine fever (CSF) was induced in 20 pigs by inoculation with a virulent strain of CSF virus to determine sequential changes (2, 4, 7, 10 and 14 days post-inoculation) in the number and morphology of splenic macrophages (red pulp and lymphoid marginal zone) and thus to assess the role of these cells in the pathogenesis of the disease. The first splenic cells to be infected with CSF virus were macrophages in the marginal zone followed by other macrophage populations. The initial phase of CSF was associated with an increase in splenic macrophage numbers in the marginal zone and a decrease in the red pulp. Subsequently, the numbers in the red pulp increased. The study suggested that infection, mobilization and apoptosis of splenic macrophages play an important role in the spread of CSF virus in vivo. Moreover, the secretory changes that occurred in macrophages in the initial phase of the infection suggested that macrophages release chemical mediators capable of modulating pathogenesis. © 2001 Harcourt Publishers Ltd.
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2001
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dig-inia-es-10261-2918032023-02-20T07:22:24Z Morphological and immunohistochemical changes in splenic macrophages of pigs infected with classical swine fever Gómez-Villamandos, J. C. Ruiz-Villamor, E. Bautista, M. J. Sánchez, C. P. Sánchez-Cordón, P. J. Salguero, F. J. Jover, A. Classical swine fever (CSF) was induced in 20 pigs by inoculation with a virulent strain of CSF virus to determine sequential changes (2, 4, 7, 10 and 14 days post-inoculation) in the number and morphology of splenic macrophages (red pulp and lymphoid marginal zone) and thus to assess the role of these cells in the pathogenesis of the disease. The first splenic cells to be infected with CSF virus were macrophages in the marginal zone followed by other macrophage populations. The initial phase of CSF was associated with an increase in splenic macrophage numbers in the marginal zone and a decrease in the red pulp. Subsequently, the numbers in the red pulp increased. The study suggested that infection, mobilization and apoptosis of splenic macrophages play an important role in the spread of CSF virus in vivo. Moreover, the secretory changes that occurred in macrophages in the initial phase of the infection suggested that macrophages release chemical mediators capable of modulating pathogenesis. © 2001 Harcourt Publishers Ltd. 2023-02-20T07:22:24Z 2023-02-20T07:22:24Z 2001 artículo Journal of Comparative Pathology 125(2-3): 98-109 (2001) 0021-9975 http://hdl.handle.net/20.500.12792/1825 http://hdl.handle.net/10261/291803 10.1053/jcpa.2001.0487 1532-3129 en none Elsevier |
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Classical swine fever (CSF) was induced in 20 pigs by inoculation with a virulent strain of CSF virus to determine sequential changes (2, 4, 7, 10 and 14 days post-inoculation) in the number and morphology of splenic macrophages (red pulp and lymphoid marginal zone) and thus to assess the role of these cells in the pathogenesis of the disease. The first splenic cells to be infected with CSF virus were macrophages in the marginal zone followed by other macrophage populations. The initial phase of CSF was associated with an increase in splenic macrophage numbers in the marginal zone and a decrease in the red pulp. Subsequently, the numbers in the red pulp increased. The study suggested that infection, mobilization and apoptosis of splenic macrophages play an important role in the spread of CSF virus in vivo. Moreover, the secretory changes that occurred in macrophages in the initial phase of the infection suggested that macrophages release chemical mediators capable of modulating pathogenesis. © 2001 Harcourt Publishers Ltd. |
format |
artículo |
author |
Gómez-Villamandos, J. C. Ruiz-Villamor, E. Bautista, M. J. Sánchez, C. P. Sánchez-Cordón, P. J. Salguero, F. J. Jover, A. |
spellingShingle |
Gómez-Villamandos, J. C. Ruiz-Villamor, E. Bautista, M. J. Sánchez, C. P. Sánchez-Cordón, P. J. Salguero, F. J. Jover, A. Morphological and immunohistochemical changes in splenic macrophages of pigs infected with classical swine fever |
author_facet |
Gómez-Villamandos, J. C. Ruiz-Villamor, E. Bautista, M. J. Sánchez, C. P. Sánchez-Cordón, P. J. Salguero, F. J. Jover, A. |
author_sort |
Gómez-Villamandos, J. C. |
title |
Morphological and immunohistochemical changes in splenic macrophages of pigs infected with classical swine fever |
title_short |
Morphological and immunohistochemical changes in splenic macrophages of pigs infected with classical swine fever |
title_full |
Morphological and immunohistochemical changes in splenic macrophages of pigs infected with classical swine fever |
title_fullStr |
Morphological and immunohistochemical changes in splenic macrophages of pigs infected with classical swine fever |
title_full_unstemmed |
Morphological and immunohistochemical changes in splenic macrophages of pigs infected with classical swine fever |
title_sort |
morphological and immunohistochemical changes in splenic macrophages of pigs infected with classical swine fever |
publisher |
Elsevier |
publishDate |
2001 |
url |
http://hdl.handle.net/20.500.12792/1825 http://hdl.handle.net/10261/291803 |
work_keys_str_mv |
AT gomezvillamandosjc morphologicalandimmunohistochemicalchangesinsplenicmacrophagesofpigsinfectedwithclassicalswinefever AT ruizvillamore morphologicalandimmunohistochemicalchangesinsplenicmacrophagesofpigsinfectedwithclassicalswinefever AT bautistamj morphologicalandimmunohistochemicalchangesinsplenicmacrophagesofpigsinfectedwithclassicalswinefever AT sanchezcp morphologicalandimmunohistochemicalchangesinsplenicmacrophagesofpigsinfectedwithclassicalswinefever AT sanchezcordonpj morphologicalandimmunohistochemicalchangesinsplenicmacrophagesofpigsinfectedwithclassicalswinefever AT salguerofj morphologicalandimmunohistochemicalchangesinsplenicmacrophagesofpigsinfectedwithclassicalswinefever AT jovera morphologicalandimmunohistochemicalchangesinsplenicmacrophagesofpigsinfectedwithclassicalswinefever |
_version_ |
1767603257235996672 |