Characterisation and functional implications of the two new HLA-G alleles found in Amerindian and Caribbean populations

HLA-G polymorphism has been found to be relatively low in all world populations. In the present paper two new HLA-G molecules are described in ancient American natives. A new HLA-G molecule from a Ecuador Amerindian individual (male) showed four codon changes with respect to HLA-G*010101. Silent changes at α1 domain (residue 57, Pro, CCG → CCA) and α2 domain (residue 93, His, CAC → CAT and residue 100, Gly, GGC → GGT) and one productive change in α3 domain (residue 219 changed from Arg to Trp). This α3 change may dramatically alter HLA-G interactions with beta-2 microglobulin, CD8, ILT-2 and ILT-4 ligands present in subsets of T, B, NK, monocytes, macrophages and dentritic cells. Another HLA-G new molecule was found in a woman from Hispaniola Island, Dominican Republic (Sto Domingo) it presented a silent change at α2 domain residue 107, Gly, GGA → GGT and non-silent change at residue 178, Met → Thr (with respect to HLA-G*010101) which is close to class I molecule/clonotypic T cell receptor interaction sites. Functional implications of these findings are discussed. © 2016 American Society for Histocompatibility and Immunogenetics

Bibliographic Details

Main Authors:	Arnaiz-Villena, A., Enriquez-de-Salamanca, M., Palacio-Grüber, J., Campos, C., Camacho, A., Martín-Villa, J. M., Martinez-Quiles, N., Gómez Casado, Eduardo, Muñiz, E.
Format:	artículo biblioteca
Language:	English
Published:	Elsevier 2016
Subjects:	Amerindians, Ecuador, Hispaniola Is, HLA-G11 HLA-G and populations, HLA-G function, HLA-G immune interaction, HLA-G ligands, ILT-2, ILT-4,
Online Access:	http://hdl.handle.net/10261/291580
Tags:	Add Tag No Tags, Be the first to tag this record!