Recombinant vaccines against bluetongue virus
Bluetongue (BT) is a hemorrhagic disease of ruminants caused by bluetongue virus (BTV), the prototype member of the genus Orbivirus within the family Reoviridae and is transmitted via biting midges of the genus Culicoides. BTV can be found on all continents except Antarctica, and up to 26 immunologically distinct BTV serotypes have been identified. Live attenuated and inactivated BTV vaccines have been used over the years with different degrees of success. The multiple outbreaks of BTV in Mediterranean Europe in the last two decades and the incursion of BTV-8 in Northern Europe in 2008 has re-stimulated the interest to develop improved vaccination strategies against BTV. In particular, safer, cross-reactive, more efficacious vaccines with differential diagnostic capability have been pursued by multiple BTV research groups and vaccine manufacturers. A wide variety of recombinant BTV vaccine prototypes have been investigated, ranging from baculovirus-expressed sub-unit vaccines to the use of live viral vectors. This article gives a brief overview of all these modern approaches to develop vaccines against BTV including some recent unpublished data. © 2013 The Authors.
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Format: | artículo de revisión biblioteca |
Language: | English |
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Elsevier
2014
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Subjects: | Bluetongue virus, Recombinant vaccines, DIVA, Heterotypic protection, |
Online Access: | http://hdl.handle.net/20.500.12792/5590 http://hdl.handle.net/10261/291405 |
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dig-inia-es-10261-2914052023-02-20T07:17:52Z Recombinant vaccines against bluetongue virus Calvo Pinilla, Eva María Castillo-Olivares, J. Jabbar, T. Ortego Alonso, Francisco Javier De la Poza, F. Marín-López, A. Bluetongue virus Recombinant vaccines DIVA Heterotypic protection Bluetongue (BT) is a hemorrhagic disease of ruminants caused by bluetongue virus (BTV), the prototype member of the genus Orbivirus within the family Reoviridae and is transmitted via biting midges of the genus Culicoides. BTV can be found on all continents except Antarctica, and up to 26 immunologically distinct BTV serotypes have been identified. Live attenuated and inactivated BTV vaccines have been used over the years with different degrees of success. The multiple outbreaks of BTV in Mediterranean Europe in the last two decades and the incursion of BTV-8 in Northern Europe in 2008 has re-stimulated the interest to develop improved vaccination strategies against BTV. In particular, safer, cross-reactive, more efficacious vaccines with differential diagnostic capability have been pursued by multiple BTV research groups and vaccine manufacturers. A wide variety of recombinant BTV vaccine prototypes have been investigated, ranging from baculovirus-expressed sub-unit vaccines to the use of live viral vectors. This article gives a brief overview of all these modern approaches to develop vaccines against BTV including some recent unpublished data. © 2013 The Authors. 2023-02-20T07:17:52Z 2023-02-20T07:17:52Z 2014 artículo de revisión Virus Research 182: 78-86 (2014) 0168-1702 http://hdl.handle.net/20.500.12792/5590 http://hdl.handle.net/10261/291405 10.1016/j.virusres.2013.11.013 1872-7492 en open Elsevier |
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Bluetongue virus Recombinant vaccines DIVA Heterotypic protection Bluetongue virus Recombinant vaccines DIVA Heterotypic protection |
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Bluetongue virus Recombinant vaccines DIVA Heterotypic protection Bluetongue virus Recombinant vaccines DIVA Heterotypic protection Calvo Pinilla, Eva María Castillo-Olivares, J. Jabbar, T. Ortego Alonso, Francisco Javier De la Poza, F. Marín-López, A. Recombinant vaccines against bluetongue virus |
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Bluetongue (BT) is a hemorrhagic disease of ruminants caused by bluetongue virus (BTV), the prototype member of the genus Orbivirus within the family Reoviridae and is transmitted via biting midges of the genus Culicoides. BTV can be found on all continents except Antarctica, and up to 26 immunologically distinct BTV serotypes have been identified. Live attenuated and inactivated BTV vaccines have been used over the years with different degrees of success. The multiple outbreaks of BTV in Mediterranean Europe in the last two decades and the incursion of BTV-8 in Northern Europe in 2008 has re-stimulated the interest to develop improved vaccination strategies against BTV. In particular, safer, cross-reactive, more efficacious vaccines with differential diagnostic capability have been pursued by multiple BTV research groups and vaccine manufacturers. A wide variety of recombinant BTV vaccine prototypes have been investigated, ranging from baculovirus-expressed sub-unit vaccines to the use of live viral vectors. This article gives a brief overview of all these modern approaches to develop vaccines against BTV including some recent unpublished data. © 2013 The Authors. |
format |
artículo de revisión |
topic_facet |
Bluetongue virus Recombinant vaccines DIVA Heterotypic protection |
author |
Calvo Pinilla, Eva María Castillo-Olivares, J. Jabbar, T. Ortego Alonso, Francisco Javier De la Poza, F. Marín-López, A. |
author_facet |
Calvo Pinilla, Eva María Castillo-Olivares, J. Jabbar, T. Ortego Alonso, Francisco Javier De la Poza, F. Marín-López, A. |
author_sort |
Calvo Pinilla, Eva María |
title |
Recombinant vaccines against bluetongue virus |
title_short |
Recombinant vaccines against bluetongue virus |
title_full |
Recombinant vaccines against bluetongue virus |
title_fullStr |
Recombinant vaccines against bluetongue virus |
title_full_unstemmed |
Recombinant vaccines against bluetongue virus |
title_sort |
recombinant vaccines against bluetongue virus |
publisher |
Elsevier |
publishDate |
2014 |
url |
http://hdl.handle.net/20.500.12792/5590 http://hdl.handle.net/10261/291405 |
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1767603213098287104 |