The bovine annexin 9 gene (ANXA9) is significantly associated with milk-fat yield in a Spanish Holstein-Friesian population

On the basis of QTL studies for milk-fat yield trait on BTA3, annexin 9 protein (ANXA9), fatty acid transport protein type 3 (SLC27A3) and diacylglycerol O-acyltransferase 1 (DGAT1) were selected as candidate genes. Three different single nucleotide polymorphisms (SNPs) of bovine ANXA9, SLC27A3 and DGAT1 genes have been tested in a selective genotyping design for milk-fat yield. Significant allele frequency differences were found for ANXA9 (p=0.02), in Holstein-Friesian animals with high and low breeding values for milk-fat yield. Regression analysis also showed a significant effect (p=0.0207) between estimated breeding values (EBVs) for fat milk content and ANXA9 polymorphism. So ANXA9 gene falls into a significant quantitative trait loci interval for milk-fat yield that was previously reported on bovine chromosome 3 in other dairy populations. Our results suggest that the ANXA9 gene polymorphism or a linked segregating QTL contributes to variation in milk-fat yield. © 2009 Elsevier Ltd.

Bibliographic Details

Main Authors:	Martínez-Royo, A., Ordovas, L., Zaragoza, P., Altarriba, J., Serrano Noreña, Magdalena, Rodellar, C., Calvo, J. H.
Format:	artículo biblioteca
Language:	English
Published:	Elsevier 2010
Subjects:	Candidate gene, ANXA9, SLC27A3, DGAT, Milk-fat yield, BTA3,
Online Access:	http://hdl.handle.net/20.500.12792/2772 http://hdl.handle.net/10261/291085
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