Effect of ageing on hormone secretion and follicular dynamics in sheep with and without the booroola gene
It has been suggested that ewes carrying the Booroola gene (Fec B) consistently ovulate more follicles because they recruit more primordial follicles and/or have a lower rate of atresia. If the former is correct, the pool of follicles would be depleted sooner in FecB animals. We have studied follicular dynamics and endocrine function during follicular and early luteal phases of the estrous cycle of older ewes with or without the fecundity gene and compared this data with data obtained 6 yr previously in the same animals. Older sheep carrying the Booroola gene maintained a significantly higher ovulation rate than noncarrier ewes [4.2 ± 0.8 vs. 2.2 ± 0.6 corpora lutea (CL), respectively; P < 0.05], and in keeping with data from young animals, both ovulatory follicles and CL (4.7 ± 0.3 vs. 6.9 ± 0.7 mm and 12.8 ± 0.5 vs. 16.7 ± 0.8 mm, respectively) were smaller than those of noncarrier ewes (P < 0.05). The interval from luteolysis to the onset of the LH surge increased with age in all the animals (from 52.0 ± 8.0 to 67.0 ± 7.5 j in gene carrier sheep and from 56.0 ± 2.0 to 79.5 ± 9.6 h in noncarrier sheep, P < 0.05). The concentration of estradiol and inhibin A in the early luteal phase was lower in older noncarrier ewes (P = 0.08 and P < 0.05, respectively), and the level of inhibin A was inversely related to the level of FSH in aged sheep of both genotypes (F < 0.0001). In contrast, the number of developing follicles in older ewes of both genotypes was similar to the number found in younger ewes, suggesting that increased ovulation rate in sheep carrying the FecB mutation is related to a reduced rate of atresia.
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2004
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dig-inia-es-10261-2899442023-02-17T08:25:47Z Effect of ageing on hormone secretion and follicular dynamics in sheep with and without the booroola gene González De Bulnes, Antonio Souza, C. J. H. Campbell, B. K. Baird, D. T. It has been suggested that ewes carrying the Booroola gene (Fec B) consistently ovulate more follicles because they recruit more primordial follicles and/or have a lower rate of atresia. If the former is correct, the pool of follicles would be depleted sooner in FecB animals. We have studied follicular dynamics and endocrine function during follicular and early luteal phases of the estrous cycle of older ewes with or without the fecundity gene and compared this data with data obtained 6 yr previously in the same animals. Older sheep carrying the Booroola gene maintained a significantly higher ovulation rate than noncarrier ewes [4.2 ± 0.8 vs. 2.2 ± 0.6 corpora lutea (CL), respectively; P < 0.05], and in keeping with data from young animals, both ovulatory follicles and CL (4.7 ± 0.3 vs. 6.9 ± 0.7 mm and 12.8 ± 0.5 vs. 16.7 ± 0.8 mm, respectively) were smaller than those of noncarrier ewes (P < 0.05). The interval from luteolysis to the onset of the LH surge increased with age in all the animals (from 52.0 ± 8.0 to 67.0 ± 7.5 j in gene carrier sheep and from 56.0 ± 2.0 to 79.5 ± 9.6 h in noncarrier sheep, P < 0.05). The concentration of estradiol and inhibin A in the early luteal phase was lower in older noncarrier ewes (P = 0.08 and P < 0.05, respectively), and the level of inhibin A was inversely related to the level of FSH in aged sheep of both genotypes (F < 0.0001). In contrast, the number of developing follicles in older ewes of both genotypes was similar to the number found in younger ewes, suggesting that increased ovulation rate in sheep carrying the FecB mutation is related to a reduced rate of atresia. 2023-02-17T08:25:47Z 2023-02-17T08:25:47Z 2004 artículo Endocrinology 145(6): 2858-2864 (2004) 0013-7227 http://hdl.handle.net/20.500.12792/1920 http://hdl.handle.net/10261/289944 10.1210/en.2003-1722 1945-7170 en none Oxford University Press |
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It has been suggested that ewes carrying the Booroola gene (Fec B) consistently ovulate more follicles because they recruit more primordial follicles and/or have a lower rate of atresia. If the former is correct, the pool of follicles would be depleted sooner in FecB animals. We have studied follicular dynamics and endocrine function during follicular and early luteal phases of the estrous cycle of older ewes with or without the fecundity gene and compared this data with data obtained 6 yr previously in the same animals. Older sheep carrying the Booroola gene maintained a significantly higher ovulation rate than noncarrier ewes [4.2 ± 0.8 vs. 2.2 ± 0.6 corpora lutea (CL), respectively; P < 0.05], and in keeping with data from young animals, both ovulatory follicles and CL (4.7 ± 0.3 vs. 6.9 ± 0.7 mm and 12.8 ± 0.5 vs. 16.7 ± 0.8 mm, respectively) were smaller than those of noncarrier ewes (P < 0.05). The interval from luteolysis to the onset of the LH surge increased with age in all the animals (from 52.0 ± 8.0 to 67.0 ± 7.5 j in gene carrier sheep and from 56.0 ± 2.0 to 79.5 ± 9.6 h in noncarrier sheep, P < 0.05). The concentration of estradiol and inhibin A in the early luteal phase was lower in older noncarrier ewes (P = 0.08 and P < 0.05, respectively), and the level of inhibin A was inversely related to the level of FSH in aged sheep of both genotypes (F < 0.0001). In contrast, the number of developing follicles in older ewes of both genotypes was similar to the number found in younger ewes, suggesting that increased ovulation rate in sheep carrying the FecB mutation is related to a reduced rate of atresia. |
format |
artículo |
author |
González De Bulnes, Antonio Souza, C. J. H. Campbell, B. K. Baird, D. T. |
spellingShingle |
González De Bulnes, Antonio Souza, C. J. H. Campbell, B. K. Baird, D. T. Effect of ageing on hormone secretion and follicular dynamics in sheep with and without the booroola gene |
author_facet |
González De Bulnes, Antonio Souza, C. J. H. Campbell, B. K. Baird, D. T. |
author_sort |
González De Bulnes, Antonio |
title |
Effect of ageing on hormone secretion and follicular dynamics in sheep with and without the booroola gene |
title_short |
Effect of ageing on hormone secretion and follicular dynamics in sheep with and without the booroola gene |
title_full |
Effect of ageing on hormone secretion and follicular dynamics in sheep with and without the booroola gene |
title_fullStr |
Effect of ageing on hormone secretion and follicular dynamics in sheep with and without the booroola gene |
title_full_unstemmed |
Effect of ageing on hormone secretion and follicular dynamics in sheep with and without the booroola gene |
title_sort |
effect of ageing on hormone secretion and follicular dynamics in sheep with and without the booroola gene |
publisher |
Oxford University Press |
publishDate |
2004 |
url |
http://hdl.handle.net/20.500.12792/1920 http://hdl.handle.net/10261/289944 |
work_keys_str_mv |
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