Consequences of in vitro culture conditions on embryo development and quality

Consequences of in vitro culture conditions on embryo development and quality

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Despite major efforts directed at improving the yield of blastocysts from immature oocytes in vitro, the quality of such blastocysts continually lags behind that of blastocysts produced in vivo. These differences are manifested at the level of morphology, metabolism, gene expression and cryotolerance, and may have a knock-on effect further along the developmental axis. Evidence suggesting that in vitro culture conditions, while capable of producing blastocysts in relatively high numbers, are far from optimal with deficiencies being manifested in terms of abnormally large offspring. It is clear nowadays that modification of the post-fertilization culture environment in vitro can improve blastocyst quality to some extent. © 2008 The Authors.

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Main Authors: Rizos Dimitrios, Dimitrios, Clemente, M., Bermejo Álvarez, Pablo, De La Fuente, J., Lonergan, P., Gutiérrez Adán, Alfonso
Format: artículo de revisión biblioteca
Language:English
Published: Wiley 2008
Online Access:http://hdl.handle.net/20.500.12792/5418
http://hdl.handle.net/10261/289824
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spelling dig-inia-es-10261-2898242023-02-17T08:24:17Z Consequences of in vitro culture conditions on embryo development and quality Rizos Dimitrios, Dimitrios Clemente, M. Bermejo Álvarez, Pablo De La Fuente, J. Lonergan, P. Gutiérrez Adán, Alfonso Despite major efforts directed at improving the yield of blastocysts from immature oocytes in vitro, the quality of such blastocysts continually lags behind that of blastocysts produced in vivo. These differences are manifested at the level of morphology, metabolism, gene expression and cryotolerance, and may have a knock-on effect further along the developmental axis. Evidence suggesting that in vitro culture conditions, while capable of producing blastocysts in relatively high numbers, are far from optimal with deficiencies being manifested in terms of abnormally large offspring. It is clear nowadays that modification of the post-fertilization culture environment in vitro can improve blastocyst quality to some extent. © 2008 The Authors. 2023-02-17T08:24:17Z 2023-02-17T08:24:17Z 2008 artículo de revisión Reproduction in Domestic Animals 43(4): 44-50 (2008) 0936-6768 http://hdl.handle.net/20.500.12792/5418 http://hdl.handle.net/10261/289824 10.1111/j.1439-0531.2008.01230.x 1439-0531 en none Wiley
institution INIA ES
collection DSpace
country España
countrycode ES
component Bibliográfico
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databasecode dig-inia-es
tag biblioteca
region Europa del Sur
libraryname Biblioteca del INIA España
language English
description Despite major efforts directed at improving the yield of blastocysts from immature oocytes in vitro, the quality of such blastocysts continually lags behind that of blastocysts produced in vivo. These differences are manifested at the level of morphology, metabolism, gene expression and cryotolerance, and may have a knock-on effect further along the developmental axis. Evidence suggesting that in vitro culture conditions, while capable of producing blastocysts in relatively high numbers, are far from optimal with deficiencies being manifested in terms of abnormally large offspring. It is clear nowadays that modification of the post-fertilization culture environment in vitro can improve blastocyst quality to some extent. © 2008 The Authors.
format artículo de revisión
author Rizos Dimitrios, Dimitrios
Clemente, M.
Bermejo Álvarez, Pablo
De La Fuente, J.
Lonergan, P.
Gutiérrez Adán, Alfonso
spellingShingle Rizos Dimitrios, Dimitrios
Clemente, M.
Bermejo Álvarez, Pablo
De La Fuente, J.
Lonergan, P.
Gutiérrez Adán, Alfonso
Consequences of in vitro culture conditions on embryo development and quality
author_facet Rizos Dimitrios, Dimitrios
Clemente, M.
Bermejo Álvarez, Pablo
De La Fuente, J.
Lonergan, P.
Gutiérrez Adán, Alfonso
author_sort Rizos Dimitrios, Dimitrios
title Consequences of in vitro culture conditions on embryo development and quality
title_short Consequences of in vitro culture conditions on embryo development and quality
title_full Consequences of in vitro culture conditions on embryo development and quality
title_fullStr Consequences of in vitro culture conditions on embryo development and quality
title_full_unstemmed Consequences of in vitro culture conditions on embryo development and quality
title_sort consequences of in vitro culture conditions on embryo development and quality
publisher Wiley
publishDate 2008
url http://hdl.handle.net/20.500.12792/5418
http://hdl.handle.net/10261/289824
work_keys_str_mv AT rizosdimitriosdimitrios consequencesofinvitrocultureconditionsonembryodevelopmentandquality
AT clementem consequencesofinvitrocultureconditionsonembryodevelopmentandquality
AT bermejoalvarezpablo consequencesofinvitrocultureconditionsonembryodevelopmentandquality
AT delafuentej consequencesofinvitrocultureconditionsonembryodevelopmentandquality
AT lonerganp consequencesofinvitrocultureconditionsonembryodevelopmentandquality
AT gutierrezadanalfonso consequencesofinvitrocultureconditionsonembryodevelopmentandquality
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