Neoplasms and novel gammaherpesviruses in critically endangered captive European minks (Mustela lutreola)
13 Päg. Centro de Investigación en Sanidad Animal (CISA)
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| Format: | artículo biblioteca |
| Language: | English |
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John Wiley & Sons
2020-07-03
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| Subjects: | Biliary cystadenoma, Herpesvirus, Lung adenocarcinoma, Lymphoma, Mustelid, Preputial cystadenoma, |
| Online Access: | http://hdl.handle.net/10261/287051 http://dx.doi.org/10.13039/501100000848 http://dx.doi.org/10.13039/501100001807 http://dx.doi.org/10.13039/501100002809 https://api.elsevier.com/content/abstract/scopus_id/85088160027 |
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dig-inia-es-10261-2870512024-05-14T20:37:47Z Neoplasms and novel gammaherpesviruses in critically endangered captive European minks (Mustela lutreola) Nicolás Francisco, Olga Esperón, Fernando Juan-Sallés, Carles Ewbank, Ana Carolina Das Neves, C. G. Marco, Alberto Neves, Elena Anderson, Neil Sacristán, Carlos University of Edinburgh Norwegian University of Life Sciences Generalitat de Catalunya Fundação de Amparo à Pesquisa do Estado de São Paulo Nicolás Francisco, Olga [0000-0003-4980-0642] Esperón, Fernando [0000-0002-8810-5071] Juan-Sallés, Carles [0000-0003-3294-6039] Ewbank, Ana Carolina [0000-0002-5617-9287] Das Neves, C. G. [0000-0003-0348-4808] Neves, Elena [0000-0002-1814-573X] Anderson, Neil [0000-0001-7192-7717] Sacristán, Carlos [0000-0002-6111-6301] Biliary cystadenoma Herpesvirus Lung adenocarcinoma Lymphoma Mustelid Preputial cystadenoma 13 Päg. Centro de Investigación en Sanidad Animal (CISA) The European mink (Mustela lutreola) is a riparian mustelid, considered one of the most endangered carnivores in the world. Alpha, beta and gammaherpesviruses described in mustelids have been occasionally associated with different pathological processes. However, there is no information about the herpesviruses species infecting European minks. In this study, 141 samples of swabs (oral, conjunctival, anal), faeces and tissues from 23 animals were analysed for herpesvirus (HV) using a pan-HV-PCR assay. Two different, potentially novel, gammaherpesvirus species were identified in 12 samples from four animals (17.3%), and tentatively named Mustelid gammaherpesvirus-2 (MUGHV-2) and MuGHV-3. Gross examination was performed on dead minks (n = 11), while histopathology was performed using available samples from HV-positive individuals (n = 2), identifying several neoplasms, including B-cell lymphoma (identified by immunohistochemistry) with intralesional syncytia and intranuclear inclusion bodies characteristic of HV (n = 1), pulmonary adenocarcinoma (n = 1), and biliary (n = 1) and preputial (n = 1) cystadenomas, as well as other lesions (e.g., axonal vacuolar degeneration [n = 2] and neuritis [n = 1]). Viral particles, consistent with HVs, were observed by electron microscopy in the mink with neural lymphoma and inclusion bodies. This is the first description of neoplasms and concurrent gammaherpesvirus infection in European minks. The pathological, ultrastructural and PCR findings (MuGHV-2) in the European mink with lymphoma strongly suggest a potential role for this novel gammaherpesvirus in its pathogenesis, as it has been reported in other HV-infected species with lymphoma. The occurrence of neural lymphoma with intralesional syncytia and herpesviral inclusions is, however, unique among mammals. Further research is warranted to elucidate the potential oncogenic properties of gammaherpesviruses in European mink and their epidemiology in the wild population. Innovation Initiative Grant (IIG) of the Edinburgh Fund (University of Edinburgh); Norwegian University of Life Sciences; Generalitat de Catalunya; São Paulo Research Foundation, Grant/Award Number: 2018/20956-08 and 2018/25069-7; University of Edinburgh Peer reviewed 2023-01-18T11:39:09Z 2023-01-18T11:39:09Z 2020-07-03 artículo http://purl.org/coar/resource_type/c_6501 Transboundary and Emerging Diseases 68(2): 552-564 (2021) 1865-1674 http://hdl.handle.net/10261/287051 10.1111/tbed.13713 http://dx.doi.org/10.13039/501100000848 http://dx.doi.org/10.13039/501100001807 http://dx.doi.org/10.13039/501100002809 32619314 2-s2.0-85088160027 https://api.elsevier.com/content/abstract/scopus_id/85088160027 en Transboundary and emerging diseases Publisher's version https://doi.org/10.1111/tbed.13713 Sí open John Wiley & Sons |
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España |
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biblioteca |
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Europa del Sur |
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| language |
English |
| topic |
Biliary cystadenoma Herpesvirus Lung adenocarcinoma Lymphoma Mustelid Preputial cystadenoma Biliary cystadenoma Herpesvirus Lung adenocarcinoma Lymphoma Mustelid Preputial cystadenoma |
| spellingShingle |
Biliary cystadenoma Herpesvirus Lung adenocarcinoma Lymphoma Mustelid Preputial cystadenoma Biliary cystadenoma Herpesvirus Lung adenocarcinoma Lymphoma Mustelid Preputial cystadenoma Nicolás Francisco, Olga Esperón, Fernando Juan-Sallés, Carles Ewbank, Ana Carolina Das Neves, C. G. Marco, Alberto Neves, Elena Anderson, Neil Sacristán, Carlos Neoplasms and novel gammaherpesviruses in critically endangered captive European minks (Mustela lutreola) |
| description |
13 Päg.
Centro de Investigación en Sanidad Animal (CISA) |
| author2 |
University of Edinburgh |
| author_facet |
University of Edinburgh Nicolás Francisco, Olga Esperón, Fernando Juan-Sallés, Carles Ewbank, Ana Carolina Das Neves, C. G. Marco, Alberto Neves, Elena Anderson, Neil Sacristán, Carlos |
| format |
artículo |
| topic_facet |
Biliary cystadenoma Herpesvirus Lung adenocarcinoma Lymphoma Mustelid Preputial cystadenoma |
| author |
Nicolás Francisco, Olga Esperón, Fernando Juan-Sallés, Carles Ewbank, Ana Carolina Das Neves, C. G. Marco, Alberto Neves, Elena Anderson, Neil Sacristán, Carlos |
| author_sort |
Nicolás Francisco, Olga |
| title |
Neoplasms and novel gammaherpesviruses in critically endangered captive European minks (Mustela lutreola) |
| title_short |
Neoplasms and novel gammaherpesviruses in critically endangered captive European minks (Mustela lutreola) |
| title_full |
Neoplasms and novel gammaherpesviruses in critically endangered captive European minks (Mustela lutreola) |
| title_fullStr |
Neoplasms and novel gammaherpesviruses in critically endangered captive European minks (Mustela lutreola) |
| title_full_unstemmed |
Neoplasms and novel gammaherpesviruses in critically endangered captive European minks (Mustela lutreola) |
| title_sort |
neoplasms and novel gammaherpesviruses in critically endangered captive european minks (mustela lutreola) |
| publisher |
John Wiley & Sons |
| publishDate |
2020-07-03 |
| url |
http://hdl.handle.net/10261/287051 http://dx.doi.org/10.13039/501100000848 http://dx.doi.org/10.13039/501100001807 http://dx.doi.org/10.13039/501100002809 https://api.elsevier.com/content/abstract/scopus_id/85088160027 |
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