Polyphenols and IUGR Pregnancies: Intrauterine Growth Restriction and Hydroxytyrosol Affect the Development and Neurotransmitter Profile of the Hippocampus in a Pig Model

Polyphenols and IUGR Pregnancies: Intrauterine Growth Restriction and Hydroxytyrosol Affect the Development and Neurotransmitter Profile of the Hippocampus in a Pig Model

15 Pág. Departamento de Reproducción animal

Saved in:
Bibliographic Details
Main Authors: Yeste, Natalia, Gómez, Néstor, Vázquez-Gómez, Marta, García-Contreras, Consolación, Pumarola, Martí, González-Bulnes, Antonio, Bassols, Anna
Other Authors: Ministerio de Economía y Competitividad (España)
Format: artículo biblioteca
Language:English
Published: Multidisciplinary Digital Publishing Institute 2021-09-22
Subjects:Brain, Hippocampus, Hydroxytyrosol, Intrauterine growth restriction, Neurotransmitters, Pig,
Online Access:http://hdl.handle.net/10261/286694
http://dx.doi.org/10.13039/501100003329
http://dx.doi.org/10.13039/501100000780
https://api.elsevier.com/content/abstract/scopus_id/85115409783
Tags: Add Tag
No Tags, Be the first to tag this record!
id dig-inia-es-10261-286694
record_format koha
spelling dig-inia-es-10261-2866942023-02-05T21:35:23Z Polyphenols and IUGR Pregnancies: Intrauterine Growth Restriction and Hydroxytyrosol Affect the Development and Neurotransmitter Profile of the Hippocampus in a Pig Model Yeste, Natalia Gómez, Néstor Vázquez-Gómez, Marta García-Contreras, Consolación Pumarola, Martí González-Bulnes, Antonio Bassols, Anna Ministerio de Economía y Competitividad (España) European Commission Ministerio de Ciencia, Innovación y Universidades (España) Yeste, Natalia (0000-0003-2471-2064) Vázquez-Gómez, Marta (0000-0002-8916-2086) García-Contreras, Consolación (0000-0003-4624-2585) Pumarola, Martí (0000-0002-0935-7941) González-Bulnes, Antonio (0000-0002-0917-4475) Bassols, Anna (0000-0003-4213-2274) Brain Hippocampus Hydroxytyrosol Intrauterine growth restriction Neurotransmitters Pig 15 Pág. Departamento de Reproducción animal Intrauterine growth restriction (IUGR) refers to poor growth of a fetus during pregnancy due to deficient maternal nutrition or oxygen supply. Supplementation of a mother's diet with antioxidants, such as hydroxytyrosol (HTX), has been proposed to ameliorate the adverse phenotypes of IUGR. In the present study, sows were treated daily with or without 1.5 mg of HTX per kilogram of feed from day 35 of pregnancy (at 30% of the total gestational period), and fetuses were sampled at day 100 of gestation. Fetuses were classified as normal body weight (NBW) or low body weight (LBW) as a consequence of IUGR, constituting four groups: NBW-Control, NBW-HTX, LBW-Control, and LBW-HTX. The brain was removed, and the hippocampus, amygdala, and prefrontal cortex were rapidly dissected. Neuronal markers were studied by immunohistochemistry, and a decrease in the number of mature neurons in the hippocampal Cornu Ammonis subfield 1 (CA1) and the Dentate Gyrus (DG) regions was observed in LBW fetuses together with a higher number of immature neurons and other alterations in neuronal morphology. Furthermore, IUGR conditions altered the neurotransmitter (NT) profile, since an increase in the serotonin (5-HT) pathway was observed in LBW fetuses. Supplementation with HTX was able to reverse the morphological and neurochemical changes, leading both characteristics to values similar to those of NBW fetuses. This research was funded by the Spanish Ministry of Economy and Competitivity (AGL2015-68463-C2-2-P to AB and projects AGL2013-48121-C3-R and AGL2016-79321-C2–1-R to AGB), co-funded by FEDER. NY and MVG are recipients of a graduate student fellowship from the Spanish FPU National Program Grant (Ministry of Science, Innovation and Universities; number FPU17/01881 and FPU14/01285) and CGC is recipient of a FPI National Program Grant (number BES-2014-070464). Peer reviewed 2023-01-12T13:27:33Z 2023-01-12T13:27:33Z 2021-09-22 artículo Antioxidants 10(10): 1505 (2021) 2076-3921 http://hdl.handle.net/10261/286694 10.3390/antiox10101505 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100000780 34679640 2-s2.0-85115409783 https://api.elsevier.com/content/abstract/scopus_id/85115409783 en #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/MINECO/AGL2015-68463-C2-2 info:eu-repo/grantAgreement/MINECO//AGL2013-48121-C3-1-R/ES/VARIABILIDAD DEL PESO AL NACIMIENTO EN EL CERDO IBERICO Y DESARROLLO DE ESTRATEGIAS PARA MITIGAR SUS EFECTOS NEGATIVOS EN CRECIMIENTO, CALIDAD Y HOMOGENEIDAD DE LA PRODUCCION/ info:eu-repo/grantAgreement/MINECO//AGL2016-79321-C2–1-R info:eu-repo/grantAgreement/MINECO//BES-2014-070464/ES/BES-2014-070464/ info:eu-repo/grantAgreement/MICIU//FPU17/01881 info:eu-repo/grantAgreement/MECD//FPU14%2F01285/ES/FPU14%2F01285/ Antioxidants (Basel, Switzerland) Publisher's version https://doi.org/10.3390/antiox10101505 Sí open Multidisciplinary Digital Publishing Institute
institution INIA ES
collection DSpace
country España
countrycode ES
component Bibliográfico
access En linea
databasecode dig-inia-es
tag biblioteca
region Europa del Sur
libraryname Biblioteca del INIA España
language English
topic Brain
Hippocampus
Hydroxytyrosol
Intrauterine growth restriction
Neurotransmitters
Pig
Brain
Hippocampus
Hydroxytyrosol
Intrauterine growth restriction
Neurotransmitters
Pig
spellingShingle Brain
Hippocampus
Hydroxytyrosol
Intrauterine growth restriction
Neurotransmitters
Pig
Brain
Hippocampus
Hydroxytyrosol
Intrauterine growth restriction
Neurotransmitters
Pig
Yeste, Natalia
Gómez, Néstor
Vázquez-Gómez, Marta
García-Contreras, Consolación
Pumarola, Martí
González-Bulnes, Antonio
Bassols, Anna
Polyphenols and IUGR Pregnancies: Intrauterine Growth Restriction and Hydroxytyrosol Affect the Development and Neurotransmitter Profile of the Hippocampus in a Pig Model
description 15 Pág. Departamento de Reproducción animal
author2 Ministerio de Economía y Competitividad (España)
author_facet Ministerio de Economía y Competitividad (España)
Yeste, Natalia
Gómez, Néstor
Vázquez-Gómez, Marta
García-Contreras, Consolación
Pumarola, Martí
González-Bulnes, Antonio
Bassols, Anna
format artículo
topic_facet Brain
Hippocampus
Hydroxytyrosol
Intrauterine growth restriction
Neurotransmitters
Pig
author Yeste, Natalia
Gómez, Néstor
Vázquez-Gómez, Marta
García-Contreras, Consolación
Pumarola, Martí
González-Bulnes, Antonio
Bassols, Anna
author_sort Yeste, Natalia
title Polyphenols and IUGR Pregnancies: Intrauterine Growth Restriction and Hydroxytyrosol Affect the Development and Neurotransmitter Profile of the Hippocampus in a Pig Model
title_short Polyphenols and IUGR Pregnancies: Intrauterine Growth Restriction and Hydroxytyrosol Affect the Development and Neurotransmitter Profile of the Hippocampus in a Pig Model
title_full Polyphenols and IUGR Pregnancies: Intrauterine Growth Restriction and Hydroxytyrosol Affect the Development and Neurotransmitter Profile of the Hippocampus in a Pig Model
title_fullStr Polyphenols and IUGR Pregnancies: Intrauterine Growth Restriction and Hydroxytyrosol Affect the Development and Neurotransmitter Profile of the Hippocampus in a Pig Model
title_full_unstemmed Polyphenols and IUGR Pregnancies: Intrauterine Growth Restriction and Hydroxytyrosol Affect the Development and Neurotransmitter Profile of the Hippocampus in a Pig Model
title_sort polyphenols and iugr pregnancies: intrauterine growth restriction and hydroxytyrosol affect the development and neurotransmitter profile of the hippocampus in a pig model
publisher Multidisciplinary Digital Publishing Institute
publishDate 2021-09-22
url http://hdl.handle.net/10261/286694
http://dx.doi.org/10.13039/501100003329
http://dx.doi.org/10.13039/501100000780
https://api.elsevier.com/content/abstract/scopus_id/85115409783
work_keys_str_mv AT yestenatalia polyphenolsandiugrpregnanciesintrauterinegrowthrestrictionandhydroxytyrosolaffectthedevelopmentandneurotransmitterprofileofthehippocampusinapigmodel
AT gomeznestor polyphenolsandiugrpregnanciesintrauterinegrowthrestrictionandhydroxytyrosolaffectthedevelopmentandneurotransmitterprofileofthehippocampusinapigmodel
AT vazquezgomezmarta polyphenolsandiugrpregnanciesintrauterinegrowthrestrictionandhydroxytyrosolaffectthedevelopmentandneurotransmitterprofileofthehippocampusinapigmodel
AT garciacontrerasconsolacion polyphenolsandiugrpregnanciesintrauterinegrowthrestrictionandhydroxytyrosolaffectthedevelopmentandneurotransmitterprofileofthehippocampusinapigmodel
AT pumarolamarti polyphenolsandiugrpregnanciesintrauterinegrowthrestrictionandhydroxytyrosolaffectthedevelopmentandneurotransmitterprofileofthehippocampusinapigmodel
AT gonzalezbulnesantonio polyphenolsandiugrpregnanciesintrauterinegrowthrestrictionandhydroxytyrosolaffectthedevelopmentandneurotransmitterprofileofthehippocampusinapigmodel
AT bassolsanna polyphenolsandiugrpregnanciesintrauterinegrowthrestrictionandhydroxytyrosolaffectthedevelopmentandneurotransmitterprofileofthehippocampusinapigmodel
_version_ 1767602946222063616

Similar Items