Maternal Supplementation with Polyphenols and Omega-3 Fatty Acids during Pregnancy: Effects on Growth, Metabolism, and Body Composition of the Offspring

Maternal Supplementation with Polyphenols and Omega-3 Fatty Acids during Pregnancy: Effects on Growth, Metabolism, and Body Composition of the Offspring

18 Pág. SGIT-INIA

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Main Authors: Heras-Molina, Ana, Pesantez, José Luis, Astiz, Susana, García-Contreras, Consolación, Vázquez-Gómez, Marta, Encinas, Teresa, Óvilo, Cristina, Isabel, Beatriz, González-Bulnes, Antonio
Other Authors: Ministerio de Economía y Competitividad (España)
Format: artículo biblioteca
Language:English
Published: Multidisciplinary Digital Publishing Institute 2020-10-22
Subjects:Antioxidants, Fatty-acids, Intrauterine-growth-restriction, Pregnancy, Swine-model,
Online Access:http://hdl.handle.net/10261/286307
http://dx.doi.org/10.13039/501100003329
http://dx.doi.org/10.13039/501100000780
https://api.elsevier.com/content/abstract/scopus_id/85094592314
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spelling dig-inia-es-10261-2863072023-01-31T21:36:28Z Maternal Supplementation with Polyphenols and Omega-3 Fatty Acids during Pregnancy: Effects on Growth, Metabolism, and Body Composition of the Offspring Heras-Molina, Ana Pesantez, José Luis Astiz, Susana García-Contreras, Consolación Vázquez-Gómez, Marta Encinas, Teresa Óvilo, Cristina Isabel, Beatriz González-Bulnes, Antonio Ministerio de Economía y Competitividad (España) European Commission Heras-Molina, Ana (0000-0001-7496-9680) Pesantez-Pacheco, José Luis (0000-0002-5669-6014) Astiz, Susana (0000-0002-9718-0903) Garcia-Contreras, Consolación (0000-0003-4624-2585) Vazquez-Gomez, Marta (0000-0002-8916-2086) Encinas, Teresa (0000-0002-2985-7257) Óvilo, Cristina (0000-0002-5738-8435) Isabel, Beatriz (0000-0001-6593-9500) Gonzalez-Bulnes, Antonio (0000-0002-0917-4475) Antioxidants Fatty-acids Intrauterine-growth-restriction Pregnancy Swine-model 18 Pág. SGIT-INIA Maternal supplementation with antioxidants and n3 PUFAs may be a promising strategy to reduce the risk of intrauterine growth restriction and preterm delivery, which may diminish the appearance of low-birth-weight neonates. The present study aimed to determine benefits and risks of a dietary supplementation combining hydroxytyrosol, a polyphenol from olive leaves and fruits, and n3 PUFAs, from linseed oil, on developmental patterns and metabolic traits of offspring in swine, a model of IUGR pregnancies. The results obtained indicate that maternal supplementation with hydroxytyrosol and n-3 fatty acids during pregnancy has no deleterious effects on the reproductive traits of the sows (prolificacy, homogeneity of the litter, and percentage of stillborns and low-birth-weight, LBW, piglets) and the postnatal features of the piglets (growth patterns, adiposity, and metabolic traits). Conversely, in spite of a lower mean weight and corpulence at birth, piglets from the supplemented sows showed higher average daily weight gain and fractional growth rate. Thus, at juvenile stages afterwards, the offspring from the treated group reached higher weight and corpulence, with increased muscle development and better lipidemic and fatty acid profiles, in spite of similar adiposity, than offspring in the control group. However, much caution and more research are still needed before practical recommendation and use in human pregnancies. The experimental work was supported by funds from the Ministry of Economy and Competitiveness (project AGL2013–48121-C3-2-R and AGL2016–79321-C2–1-R), co-funded by FEDER. AHM, CGC, and MVG were backed by the Spanish Government (AHM: FPI National Program Grant BES-2017-080541; CGC: FPI National Program Grant BES-2014-070464; MVG: FPU National Program Grant FPU014/01285) Peer reviewed 2023-01-09T11:51:57Z 2023-01-09T11:51:57Z 2020-10-22 artículo Animals 10(11): 1946 (2020) 2076-2615 http://hdl.handle.net/10261/286307 10.3390/ani10111946 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100000780 33105758 2-s2.0-85094592314 https://api.elsevier.com/content/abstract/scopus_id/85094592314 en #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/MINECO//AGL2013–48121-C3-2-R info:eu-repo/grantAgreement/MINECO//AGL2016–79321-C2–1-R info:eu-repo/grantAgreement/MINECO//BES-2017-080541 info:eu-repo/grantAgreement/MINECO//BES-2014-070464/ES/BES-2014-070464/ info:eu-repo/grantAgreement/MINECO//FPU014/01285 Animals : an open access journal from MDPI Publisher's version https://doi.org/10.3390/ani10111946 Sí open Multidisciplinary Digital Publishing Institute
institution INIA ES
collection DSpace
country España
countrycode ES
component Bibliográfico
access En linea
databasecode dig-inia-es
tag biblioteca
region Europa del Sur
libraryname Biblioteca del INIA España
language English
topic Antioxidants
Fatty-acids
Intrauterine-growth-restriction
Pregnancy
Swine-model
Antioxidants
Fatty-acids
Intrauterine-growth-restriction
Pregnancy
Swine-model
spellingShingle Antioxidants
Fatty-acids
Intrauterine-growth-restriction
Pregnancy
Swine-model
Antioxidants
Fatty-acids
Intrauterine-growth-restriction
Pregnancy
Swine-model
Heras-Molina, Ana
Pesantez, José Luis
Astiz, Susana
García-Contreras, Consolación
Vázquez-Gómez, Marta
Encinas, Teresa
Óvilo, Cristina
Isabel, Beatriz
González-Bulnes, Antonio
Maternal Supplementation with Polyphenols and Omega-3 Fatty Acids during Pregnancy: Effects on Growth, Metabolism, and Body Composition of the Offspring
description 18 Pág. SGIT-INIA
author2 Ministerio de Economía y Competitividad (España)
author_facet Ministerio de Economía y Competitividad (España)
Heras-Molina, Ana
Pesantez, José Luis
Astiz, Susana
García-Contreras, Consolación
Vázquez-Gómez, Marta
Encinas, Teresa
Óvilo, Cristina
Isabel, Beatriz
González-Bulnes, Antonio
format artículo
topic_facet Antioxidants
Fatty-acids
Intrauterine-growth-restriction
Pregnancy
Swine-model
author Heras-Molina, Ana
Pesantez, José Luis
Astiz, Susana
García-Contreras, Consolación
Vázquez-Gómez, Marta
Encinas, Teresa
Óvilo, Cristina
Isabel, Beatriz
González-Bulnes, Antonio
author_sort Heras-Molina, Ana
title Maternal Supplementation with Polyphenols and Omega-3 Fatty Acids during Pregnancy: Effects on Growth, Metabolism, and Body Composition of the Offspring
title_short Maternal Supplementation with Polyphenols and Omega-3 Fatty Acids during Pregnancy: Effects on Growth, Metabolism, and Body Composition of the Offspring
title_full Maternal Supplementation with Polyphenols and Omega-3 Fatty Acids during Pregnancy: Effects on Growth, Metabolism, and Body Composition of the Offspring
title_fullStr Maternal Supplementation with Polyphenols and Omega-3 Fatty Acids during Pregnancy: Effects on Growth, Metabolism, and Body Composition of the Offspring
title_full_unstemmed Maternal Supplementation with Polyphenols and Omega-3 Fatty Acids during Pregnancy: Effects on Growth, Metabolism, and Body Composition of the Offspring
title_sort maternal supplementation with polyphenols and omega-3 fatty acids during pregnancy: effects on growth, metabolism, and body composition of the offspring
publisher Multidisciplinary Digital Publishing Institute
publishDate 2020-10-22
url http://hdl.handle.net/10261/286307
http://dx.doi.org/10.13039/501100003329
http://dx.doi.org/10.13039/501100000780
https://api.elsevier.com/content/abstract/scopus_id/85094592314
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