A coupled mechano-biochemical model for cell polarity guided anisotropic root growth
36 Päg. Centro de Biotecnología y Genómica de Plantas (CBGP)
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| Format: | artículo biblioteca |
| Language: | English |
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eLife Sciences Publications
2021-11-01
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| Subjects: | A. thaliana, Auxin transport, Cell polarity, Computational biology, Computer models, Plant biology, Root meristem growth, Symmetry breaking, Systems biology, |
| Online Access: | http://hdl.handle.net/10261/282623 http://dx.doi.org/10.13039/501100011033 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/100012818 https://api.elsevier.com/content/abstract/scopus_id/85120167375 |
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dig-inia-es-10261-2826232024-05-18T20:36:51Z A coupled mechano-biochemical model for cell polarity guided anisotropic root growth Marconi, Marco Gallemí, Marçal Benkova, Eva Wabnik, Krzysztof Comunidad de Madrid Agencia Estatal de Investigación (España) Ministerio de Ciencia e Innovación (España) Marconi, Marco [0000-0002-3457-1384] Gallemi, Marcal [0000-0003-4675-6893] Wabnik, Krzysztof [0000-0001-7263-0560] A. thaliana Auxin transport Cell polarity Computational biology Computer models Plant biology Root meristem growth Symmetry breaking Systems biology 36 Päg. Centro de Biotecnología y Genómica de Plantas (CBGP) Plants develop new organs to adjust their bodies to dynamic changes in the environment. How independent organs achieve anisotropic shapes and polarities is poorly understood. To address this question, we constructed a mechano-biochemical model for Arabidopsis root meristem growth that integrates biologically plausible principles. Computer model simulations demonstrate how differential growth of neighboring tissues results in the initial symmetry-breaking leading to anisotropic root growth. Furthermore, the root growth feeds back on a polar transport network of the growth regulator auxin. Model, predictions are in close agreement with in vivo patterns of anisotropic growth, auxin distribution, and cell polarity, as well as several root phenotypes caused by chemical, mechanical, or genetic perturbations. Our study demonstrates that the combination of tissue mechanics and polar auxin transport organizes anisotropic root growth and cell polarities during organ outgrowth. Therefore, a mobile auxin signal transported through immobile cells drives polarity and growth mechanics to coordinate complex organ development. This work was supported by the Programa de Atraccion de Talento 2017 (Comunidad de Madrid, 2017-T1/BIO-5654 to K.W.), Severo Ochoa (SO) Programme for Centres of Excellence in R&D from the Agencia Estatal de Investigacion of Spain (grant SEV-2016-0672 (2017-2021) to K.W. via the CBGP). In the frame of SEV-2016-0672 funding M.M. is supported with a postdoctoral contract. K.W. was supported by Programa Estatal de Generacion del Conocimiento y Fortalecimiento Cientıfico y Tecnologico del Sistema de I+D+I 2019 (PGC2018-093387-AI00) from MICIU (to K.W.). MG is recipient of an IST Interdisciplinary Project (IC1022IPC03). Peer reviewed 2022-11-10T08:48:25Z 2022-11-10T08:48:25Z 2021-11-01 artículo http://purl.org/coar/resource_type/c_6501 eLife 10: e72132 (2021) 2050-084X http://hdl.handle.net/10261/282623 10.7554/eLife.72132 http://dx.doi.org/10.13039/501100011033 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/100012818 34723798 2-s2.0-85120167375 https://api.elsevier.com/content/abstract/scopus_id/85120167375 en #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# 2017-T1/BIO-5654 info:eu-repo/grantAgreement/MICIU//PGC2018-093387-AI00 eLife Publisher's version https://doi.org/10.7554/eLife.72132 Sí open eLife Sciences Publications |
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| topic |
A. thaliana Auxin transport Cell polarity Computational biology Computer models Plant biology Root meristem growth Symmetry breaking Systems biology A. thaliana Auxin transport Cell polarity Computational biology Computer models Plant biology Root meristem growth Symmetry breaking Systems biology |
| spellingShingle |
A. thaliana Auxin transport Cell polarity Computational biology Computer models Plant biology Root meristem growth Symmetry breaking Systems biology A. thaliana Auxin transport Cell polarity Computational biology Computer models Plant biology Root meristem growth Symmetry breaking Systems biology Marconi, Marco Gallemí, Marçal Benkova, Eva Wabnik, Krzysztof A coupled mechano-biochemical model for cell polarity guided anisotropic root growth |
| description |
36 Päg.
Centro de Biotecnología y Genómica de Plantas (CBGP) |
| author2 |
Comunidad de Madrid |
| author_facet |
Comunidad de Madrid Marconi, Marco Gallemí, Marçal Benkova, Eva Wabnik, Krzysztof |
| format |
artículo |
| topic_facet |
A. thaliana Auxin transport Cell polarity Computational biology Computer models Plant biology Root meristem growth Symmetry breaking Systems biology |
| author |
Marconi, Marco Gallemí, Marçal Benkova, Eva Wabnik, Krzysztof |
| author_sort |
Marconi, Marco |
| title |
A coupled mechano-biochemical model for cell polarity guided anisotropic root growth |
| title_short |
A coupled mechano-biochemical model for cell polarity guided anisotropic root growth |
| title_full |
A coupled mechano-biochemical model for cell polarity guided anisotropic root growth |
| title_fullStr |
A coupled mechano-biochemical model for cell polarity guided anisotropic root growth |
| title_full_unstemmed |
A coupled mechano-biochemical model for cell polarity guided anisotropic root growth |
| title_sort |
coupled mechano-biochemical model for cell polarity guided anisotropic root growth |
| publisher |
eLife Sciences Publications |
| publishDate |
2021-11-01 |
| url |
http://hdl.handle.net/10261/282623 http://dx.doi.org/10.13039/501100011033 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/100012818 https://api.elsevier.com/content/abstract/scopus_id/85120167375 |
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1802819667569410048 |