Synchronization of gene expression across eukaryotic communities through chemical rhythms
10 Pág. Centro de Biotecnología y Genómica de Plantas (CBGP)
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| Language: | English |
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Nature Publishing Group
2021-06-29
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| Subjects: | Biochemical Phenomena, Cell Cycle, Gene Expression, Gene Expression Regulation, Fungal, Repressor Proteins, Saccharomyces cerevisiae, |
| Online Access: | http://hdl.handle.net/10261/281367 http://dx.doi.org/10.13039/501100011033 http://dx.doi.org/10.13039/100012818 https://api.elsevier.com/content/abstract/scopus_id/85108947727 |
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dig-inia-es-10261-2813672023-01-31T21:36:28Z Synchronization of gene expression across eukaryotic communities through chemical rhythms Pérez-García, Sara García-Navarrete, Mario Ruiz-Sanchis, Diego Prieto-Navarro, Cristina Avdovic, Merisa Pucciariello, Ornella Wabnik, Krzysztof Comunidad de Madrid Agencia Estatal de Investigación (España) Ministerio de Ciencia, Innovación y Universidades (España) Pérez-García, Sara [0000-0003-0059-1181] García-Navarrete, Mario [0000-0002-1899-8206] Ruiz-Sanchis, Diego [0000-0002-2497-071X] Prieto-Navarro, Cristina [0000-0002-4202-1307] Avdovic, Merisa [0000-0002-7688-5541] Pucciariello, Ornella [0000-0002-5241-5385] Wabnik, Krzysztof [0000-0001-7263-0560] Biochemical Phenomena Cell Cycle Gene Expression Gene Expression Regulation Fungal Repressor Proteins Saccharomyces cerevisiae 10 Pág. Centro de Biotecnología y Genómica de Plantas (CBGP) The synchronization is a recurring phenomenon in neuroscience, ecology, human sciences, and biology. However, controlling synchronization in complex eukaryotic consortia on extended spatial-temporal scales remains a major challenge. Here, to address this issue we construct a minimal synthetic system that directly converts chemical signals into a coherent gene expression synchronized among eukaryotic communities through rate-dependent hysteresis. Guided by chemical rhythms, isolated colonies of yeast Saccharomyces cerevisiae oscillate in near-perfect synchrony despite the absence of intercellular coupling or intrinsic oscillations. Increased speed of chemical rhythms and incorporation of feedback in the system architecture can tune synchronization and precision of the cell responses in a growing cell collectives. This synchronization mechanism remain robust under stress in the two-strain consortia composed of toxin-sensitive and toxin-producing strains. The sensitive cells can maintain the spatial-temporal synchronization for extended periods under the rhythmic toxin dosages produced by killer cells. Our study provides a simple molecular framework for generating global coordination of eukaryotic gene expression through dynamic environment. This work was supported by the Programa de Atraccion de Talento 2017 (Comunidad de Madrid, 2017-T1/BIO-5654 to K.W.), Severo Ochoa (SO) Programme for Centres of Excellence in R&D from the Agencia Estatal de Investigacion of Spain (grant SEV-2016-0672 (2017-2021) to K.W. via the CBGP). In the frame of SEV-2016-0672 funding M.A. received a PhD fellowship (SEV-2016-0672-18-3: PRE2018-084946) and O.P. is supported with a postdoctoral contract. K.W. was supported by Programa Estatal de Generacion del Conocimiento y Fortalecimiento Cientıfico y Tecnologico del Sistema de I + D + I 2019 (PGC2018-093387-A-I00) from MICIU (to K.W.). UPM Plan Propio Predoctoral fellow finances M. G.N. Peer reviewed 2022-10-21T07:56:33Z 2022-10-21T07:56:33Z 2021-06-29 artículo Nature Communications 12(1) : 4017 (2021) 2041-1723 http://hdl.handle.net/10261/281367 10.1038/s41467-021-24325-z http://dx.doi.org/10.13039/501100011033 http://dx.doi.org/10.13039/100012818 34188048 2-s2.0-85108947727 https://api.elsevier.com/content/abstract/scopus_id/85108947727 en #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# 2017-T1/BIO-5654 info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PGC2018-093387-A-I00/ES/ELUCIDANDO LAS BASES PARA EL DISEÑO DE LOS CIRCUITOS DE LA SEÑALIZACION HORMONAL DURANTE CAMBIOS AMBIENTALES DINAMICOS/ Nature communications Publisher's version https://doi.org/10.1038/s41467-021-24325-z | Sí open Nature Publishing Group |
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Biochemical Phenomena Cell Cycle Gene Expression Gene Expression Regulation Fungal Repressor Proteins Saccharomyces cerevisiae Biochemical Phenomena Cell Cycle Gene Expression Gene Expression Regulation Fungal Repressor Proteins Saccharomyces cerevisiae |
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Biochemical Phenomena Cell Cycle Gene Expression Gene Expression Regulation Fungal Repressor Proteins Saccharomyces cerevisiae Biochemical Phenomena Cell Cycle Gene Expression Gene Expression Regulation Fungal Repressor Proteins Saccharomyces cerevisiae Pérez-García, Sara García-Navarrete, Mario Ruiz-Sanchis, Diego Prieto-Navarro, Cristina Avdovic, Merisa Pucciariello, Ornella Wabnik, Krzysztof Synchronization of gene expression across eukaryotic communities through chemical rhythms |
| description |
10 Pág.
Centro de Biotecnología y Genómica de Plantas (CBGP) |
| author2 |
Comunidad de Madrid |
| author_facet |
Comunidad de Madrid Pérez-García, Sara García-Navarrete, Mario Ruiz-Sanchis, Diego Prieto-Navarro, Cristina Avdovic, Merisa Pucciariello, Ornella Wabnik, Krzysztof |
| format |
artículo |
| topic_facet |
Biochemical Phenomena Cell Cycle Gene Expression Gene Expression Regulation Fungal Repressor Proteins Saccharomyces cerevisiae |
| author |
Pérez-García, Sara García-Navarrete, Mario Ruiz-Sanchis, Diego Prieto-Navarro, Cristina Avdovic, Merisa Pucciariello, Ornella Wabnik, Krzysztof |
| author_sort |
Pérez-García, Sara |
| title |
Synchronization of gene expression across eukaryotic communities through chemical rhythms |
| title_short |
Synchronization of gene expression across eukaryotic communities through chemical rhythms |
| title_full |
Synchronization of gene expression across eukaryotic communities through chemical rhythms |
| title_fullStr |
Synchronization of gene expression across eukaryotic communities through chemical rhythms |
| title_full_unstemmed |
Synchronization of gene expression across eukaryotic communities through chemical rhythms |
| title_sort |
synchronization of gene expression across eukaryotic communities through chemical rhythms |
| publisher |
Nature Publishing Group |
| publishDate |
2021-06-29 |
| url |
http://hdl.handle.net/10261/281367 http://dx.doi.org/10.13039/501100011033 http://dx.doi.org/10.13039/100012818 https://api.elsevier.com/content/abstract/scopus_id/85108947727 |
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