Molecular and Phenotypic Characterization of a Multidrug-Resistant Escherichia coli Coproducing OXA-232 and MCR-1.1 in Argentina
511-516 pp
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| Language: | English |
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Mary Ann Liebert
2022-05
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| Subjects: | Carbapenemases, Colistin resistance, Multidrug resistance, Nosocomial infections, |
| Online Access: | http://hdl.handle.net/10261/274668 https://api.elsevier.com/content/abstract/scopus_id/85130645000 |
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dig-inia-es-10261-2746682024-05-16T20:37:54Z Molecular and Phenotypic Characterization of a Multidrug-Resistant Escherichia coli Coproducing OXA-232 and MCR-1.1 in Argentina García, Javier F. Nastro, Marcela Dabos, Laura Campos, Josefina Traglia, German Ocampo, Cecilia Vera Famiglietti, Angela Rodriguez, Carlos Vay, Carlos A Nastro, Marcela [0000-0002-1708-8104] Dabos, Laura [0000-0001-6740-5043] Campos, Josefina [0000-0003-1409-0441] Traglia, German [0000-0002-4780-5311] Famiglietti, Angela [0000-0002-0881-9489] Carbapenemases Colistin resistance Multidrug resistance Nosocomial infections 511-516 pp The spread of carbapenem-resistant Enterobacterales has raised concern in clinical settings due to the limited therapeutic options available. OXA-48-like enzymes are still sporadic in South America. The aim of this study was to characterize a multidrug-resistant Escherichia coli isolate from a hospitalized patient in Buenos Aires city. The isolate was characterized phenotypically by determination of its susceptibility pattern, synergistic and colorimetric tests, and molecularly, by PCR, whole genome sequencing, and plasmid analysis. It belonged to ST-744, phylogroup A, and serotype O162/O89: H9. It remained susceptible to ceftazidime, meropenem, aminoglycosides, trimethoprim/sulfamethoxazole, and tigecycline. The presence of blaOXA-232 harbored by a nonconjugative plasmid ColKp3, and blaCTX-M-14, mcr-1.1, and fosL1 in 2 conjugative plasmids, together with their genetic environment, was revealed. To the best of our knowledge, this is the first report of the coproduction of the enzyme OXA-232 and the mcr-1.1 gene in an E. coli clinical isolate in South America in a patient who had not received colistin therapy. Peer reviewed 2022-07-04T09:50:06Z 2022-07-04T09:50:06Z 2022-05 artículo http://purl.org/coar/resource_type/c_6501 Microbial Drug Resistance 28(5): 511-516 (2022) 1076-6294 http://hdl.handle.net/10261/274668 10.1089/mdr.2021.0167 1931-8448 35275771 2-s2.0-85130645000 https://api.elsevier.com/content/abstract/scopus_id/85130645000 en Microbial drug resistance (Larchmont, N.Y.) 1931-8448 Postprint https://doi.org/10.1089/mdr.2021.0167 Sí open Mary Ann Liebert |
| institution |
INIA ES |
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España |
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ES |
| component |
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| databasecode |
dig-inia-es |
| tag |
biblioteca |
| region |
Europa del Sur |
| libraryname |
Biblioteca del INIA España |
| language |
English |
| topic |
Carbapenemases Colistin resistance Multidrug resistance Nosocomial infections Carbapenemases Colistin resistance Multidrug resistance Nosocomial infections |
| spellingShingle |
Carbapenemases Colistin resistance Multidrug resistance Nosocomial infections Carbapenemases Colistin resistance Multidrug resistance Nosocomial infections García, Javier F. Nastro, Marcela Dabos, Laura Campos, Josefina Traglia, German Ocampo, Cecilia Vera Famiglietti, Angela Rodriguez, Carlos Vay, Carlos A Molecular and Phenotypic Characterization of a Multidrug-Resistant Escherichia coli Coproducing OXA-232 and MCR-1.1 in Argentina |
| description |
511-516 pp |
| author2 |
Nastro, Marcela [0000-0002-1708-8104] |
| author_facet |
Nastro, Marcela [0000-0002-1708-8104] García, Javier F. Nastro, Marcela Dabos, Laura Campos, Josefina Traglia, German Ocampo, Cecilia Vera Famiglietti, Angela Rodriguez, Carlos Vay, Carlos A |
| format |
artículo |
| topic_facet |
Carbapenemases Colistin resistance Multidrug resistance Nosocomial infections |
| author |
García, Javier F. Nastro, Marcela Dabos, Laura Campos, Josefina Traglia, German Ocampo, Cecilia Vera Famiglietti, Angela Rodriguez, Carlos Vay, Carlos A |
| author_sort |
García, Javier F. |
| title |
Molecular and Phenotypic Characterization of a Multidrug-Resistant Escherichia coli Coproducing OXA-232 and MCR-1.1 in Argentina |
| title_short |
Molecular and Phenotypic Characterization of a Multidrug-Resistant Escherichia coli Coproducing OXA-232 and MCR-1.1 in Argentina |
| title_full |
Molecular and Phenotypic Characterization of a Multidrug-Resistant Escherichia coli Coproducing OXA-232 and MCR-1.1 in Argentina |
| title_fullStr |
Molecular and Phenotypic Characterization of a Multidrug-Resistant Escherichia coli Coproducing OXA-232 and MCR-1.1 in Argentina |
| title_full_unstemmed |
Molecular and Phenotypic Characterization of a Multidrug-Resistant Escherichia coli Coproducing OXA-232 and MCR-1.1 in Argentina |
| title_sort |
molecular and phenotypic characterization of a multidrug-resistant escherichia coli coproducing oxa-232 and mcr-1.1 in argentina |
| publisher |
Mary Ann Liebert |
| publishDate |
2022-05 |
| url |
http://hdl.handle.net/10261/274668 https://api.elsevier.com/content/abstract/scopus_id/85130645000 |
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