Metabolism of oak leaf ellagitannins and urolithin production in beef cattle
10 páginas, 8 figuras, 3 tablas.
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| Language: | English |
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American Chemical Society
2012-03
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| Subjects: | Urolithins, Ellagitannins, Metabolism, Polyphenols, Hidrolyzable tannins, Oak leaves, Cattle intoxication, |
| Online Access: | http://hdl.handle.net/10261/48877 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/100007801 http://dx.doi.org/10.13039/501100003339 |
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dig-igm-es-10261-488772019-02-06T12:23:10Z Metabolism of oak leaf ellagitannins and urolithin production in beef cattle González-Barrio, Rocío Truchado, Pilar García-Villalba, Rocío Hervás, Gonzalo Frutos, Pilar Espín de Gea, Juan Carlos Tomás Barberán, Francisco Ministerio de Economía y Competitividad (España) Fundación Séneca Consejo Superior de Investigaciones Científicas (España) Urolithins Ellagitannins Metabolism Polyphenols Hidrolyzable tannins Oak leaves Cattle intoxication 10 páginas, 8 figuras, 3 tablas. Oak leaves have a high concentration of ellagitannins. These phytochemicals can be beneficial or poisonous to animals. Beef cattle are often intoxicated by oak leaf consumption, particularly after suffering feed restriction. The severity of the poisoning has recently been associated with the ruminal microbiota, as different bacterial populations were found in animals that tolerated oak leaves and in those that showed clinical and pathological signs of toxicity. Intoxication has previously been linked to the production of phenolic metabolites, particularly catechol, phloroglucinol, and resorcinol. This suggested that the microbial metabolism of ellagitannins could also be associated with its tolerance or intoxication in different animals. Therefore, it is essential to understand the metabolism of ellagitannins in cattle. Here we show that ellagitannins are metabolized in the cattle rumen to urolithins. Different urolithins were detected in ruminal fluid, feces, urine, and plasma. Oak leaf ellagitannins declined as they were converted to urolithins, mainly isourolithin A and urolithin B, by the ruminal and fecal microbiota. Urolithin aglycons were observed in rumen and feces, and glucuronide and sulfate derivatives were detected in plasma and urine. Sulfate derivatives were the main metabolites detected in plasma, while glucuronide derivatives were the main ones in urine. The main urolithins produced in cattle were isourolithin A and urolithin B. This is a relevant difference from the monogastric mammals studied previously in which urolithin A was the main metabolite produced. Low molecular weight phenolics of the benzoic, phenylacetic, and phenylpropionic groups and metabolites such as catechol, resorcinol, and related compounds were also detected. There was a large variability in the kinetics of production of these metabolites in individual animals, although they produced similar metabolites in all cases. This large variability could be associated with the large variability in the rumen and intestine microbiota that has previously been observed. Further studies are needed to demonstrate if the efficiency in the metabolism of ellagitannins by the microbiota could explain the differences observed in susceptibility to intoxication by the different animals. This work has been supported by the Spanish MICINN (Consolider Ingenio 2010-Fun-C-Food CSD2007-0063 and AGL2004-06076-C02-01) and Fundación Seneca de la Region de Murcia (grupo de excelencia GERM 06, 04486). R.G-V. holds a postdoctoral grant from the CSIC (Programme JAEDOC). Peer reviewed 2012-04-25T08:00:19Z 2012-04-25T08:00:19Z 2012-03 artículo http://purl.org/coar/resource_type/c_6501 Journal of Agricultural and Food Chemistry 60 (12) : 3068-3077 (2012) 0021-8561 http://hdl.handle.net/10261/48877 10.1021/jf300718k http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/100007801 http://dx.doi.org/10.13039/501100003339 en http://dx.doi.org/10.1021/jf300718k none American Chemical Society |
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Urolithins Ellagitannins Metabolism Polyphenols Hidrolyzable tannins Oak leaves Cattle intoxication Urolithins Ellagitannins Metabolism Polyphenols Hidrolyzable tannins Oak leaves Cattle intoxication |
| spellingShingle |
Urolithins Ellagitannins Metabolism Polyphenols Hidrolyzable tannins Oak leaves Cattle intoxication Urolithins Ellagitannins Metabolism Polyphenols Hidrolyzable tannins Oak leaves Cattle intoxication González-Barrio, Rocío Truchado, Pilar García-Villalba, Rocío Hervás, Gonzalo Frutos, Pilar Espín de Gea, Juan Carlos Tomás Barberán, Francisco Metabolism of oak leaf ellagitannins and urolithin production in beef cattle |
| description |
10 páginas, 8 figuras, 3 tablas. |
| author2 |
Ministerio de Economía y Competitividad (España) |
| author_facet |
Ministerio de Economía y Competitividad (España) González-Barrio, Rocío Truchado, Pilar García-Villalba, Rocío Hervás, Gonzalo Frutos, Pilar Espín de Gea, Juan Carlos Tomás Barberán, Francisco |
| format |
artículo |
| topic_facet |
Urolithins Ellagitannins Metabolism Polyphenols Hidrolyzable tannins Oak leaves Cattle intoxication |
| author |
González-Barrio, Rocío Truchado, Pilar García-Villalba, Rocío Hervás, Gonzalo Frutos, Pilar Espín de Gea, Juan Carlos Tomás Barberán, Francisco |
| author_sort |
González-Barrio, Rocío |
| title |
Metabolism of oak leaf ellagitannins and urolithin production in beef cattle |
| title_short |
Metabolism of oak leaf ellagitannins and urolithin production in beef cattle |
| title_full |
Metabolism of oak leaf ellagitannins and urolithin production in beef cattle |
| title_fullStr |
Metabolism of oak leaf ellagitannins and urolithin production in beef cattle |
| title_full_unstemmed |
Metabolism of oak leaf ellagitannins and urolithin production in beef cattle |
| title_sort |
metabolism of oak leaf ellagitannins and urolithin production in beef cattle |
| publisher |
American Chemical Society |
| publishDate |
2012-03 |
| url |
http://hdl.handle.net/10261/48877 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/100007801 http://dx.doi.org/10.13039/501100003339 |
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