Novel compound shows in vivo anthelmintic activity in gerbils and sheep infected by Haemonchus contortus
8 páginas, 2 figuras, 2 tablas.
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Springer Nature
2022
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| Online Access: | http://hdl.handle.net/10261/279547 http://dx.doi.org/10.13039/501100014180 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100003329 |
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dig-igm-es-10261-2795472022-09-23T10:48:11Z Novel compound shows in vivo anthelmintic activity in gerbils and sheep infected by Haemonchus contortus Valderas-García, E. Escala, N. Álvarez-Bardón, M. Castilla Gómez de Agüero, V. Cambra-Pellejà, M. González Del Palacio, L. Vallejo, R. De La Vega, J. San Feliciano, A. Del Olmo, E. Martínez Valladares, María Ministerio de Economía y Competitividad (España) Ministerio de Ciencia e Innovación (España) Junta de Castilla y León 8 páginas, 2 figuras, 2 tablas. The control of gastrointestinal nematodes in livestock is becoming increasingly difficult due to the limited number of available drugs and the rapid development of anthelmintic resistance. Therefore, it is imperative to develop new anthelmintics that are effective against nematodes. Under this context, we tested the potential toxicity of three compounds in mice and their potential anthelmintic efficacy in Mongolian gerbils infected with Haemonchus contortus. The compounds were selected from previous in vitro experiments: two diamine (AAD-1 and AAD-2) and one benzimidazole (2aBZ) derivatives. 2aBZ was also selected to test its efficacy in sheep. In Mongolian gerbils, the benzimidazole reduced the percentage of pre-adults present in the stomach of gerbils by 95% at a dose of 200 mg/kg. In sheep, there was a 99% reduction in the number of eggs shed in faeces after 7 days at a dose of 120 mg/kg and a 95% reduction in the number of worm adults present in the abomasum. In conclusion, 2aBZ could be considered a promising candidate for the treatment of helminth infections in small ruminants. © 2022, The Author(s). Financial support came from MINECO: RETOS (AGL2016-79813-C2-1R/2R) and MICINN/AEI (PID2020- 119035RB-100). EVG was funded by FPU17/00627, FPU17/05346; VCGA, MAB, MCP and LGP are recipients of Junta de Castilla y León (JCyL) (LE082-18, LE051-18, LE135-19, LE096-20, respectively) and MMV by the Spanish “Ramon y Cajal” Programme (Ministerio de Economía y competitividad; MMV, RYC-2015-18368). Peer reviewed 2022-09-21T12:30:03Z 2022-09-21T12:30:03Z 2022 2022-09-21T12:30:03Z artículo doi: 10.1038/s41598-022-17112-3 issn: 2045-2322 Scientific Reports 12: 13004 (2022) http://hdl.handle.net/10261/279547 10.1038/s41598-022-17112-3 http://dx.doi.org/10.13039/501100014180 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100003329 #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/MINECO//AGL2016-79813-C2-2-R info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-119035RB-I00/ES/NUEVAS HERRAMIENTAS PARA EL DESCUBRIMIENTO DE FARMACOS Y LA DETECCION DE RESISTENCIAS ANTIHELMINTICAS FRENTE A LAS NEMATODOSIS GASTROINTESTINALES EN PEQUEÑOS RUMIANTES / info:eu-repo/grantAgreement/MINECO//RYC-2015-18368/ES/RYC-2015-18368/ info:eu-repo/grantAgreement/MINECO//AGL2016-79813-C2-1-R Publisher's version http://dx.doi.org/10.1038/s41598-022-17112-3 Sí open Springer Nature |
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8 páginas, 2 figuras, 2 tablas. |
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Ministerio de Economía y Competitividad (España) |
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Ministerio de Economía y Competitividad (España) Valderas-García, E. Escala, N. Álvarez-Bardón, M. Castilla Gómez de Agüero, V. Cambra-Pellejà, M. González Del Palacio, L. Vallejo, R. De La Vega, J. San Feliciano, A. Del Olmo, E. Martínez Valladares, María |
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| author |
Valderas-García, E. Escala, N. Álvarez-Bardón, M. Castilla Gómez de Agüero, V. Cambra-Pellejà, M. González Del Palacio, L. Vallejo, R. De La Vega, J. San Feliciano, A. Del Olmo, E. Martínez Valladares, María |
| spellingShingle |
Valderas-García, E. Escala, N. Álvarez-Bardón, M. Castilla Gómez de Agüero, V. Cambra-Pellejà, M. González Del Palacio, L. Vallejo, R. De La Vega, J. San Feliciano, A. Del Olmo, E. Martínez Valladares, María Novel compound shows in vivo anthelmintic activity in gerbils and sheep infected by Haemonchus contortus |
| author_sort |
Valderas-García, E. |
| title |
Novel compound shows in vivo anthelmintic activity in gerbils and sheep infected by Haemonchus contortus |
| title_short |
Novel compound shows in vivo anthelmintic activity in gerbils and sheep infected by Haemonchus contortus |
| title_full |
Novel compound shows in vivo anthelmintic activity in gerbils and sheep infected by Haemonchus contortus |
| title_fullStr |
Novel compound shows in vivo anthelmintic activity in gerbils and sheep infected by Haemonchus contortus |
| title_full_unstemmed |
Novel compound shows in vivo anthelmintic activity in gerbils and sheep infected by Haemonchus contortus |
| title_sort |
novel compound shows in vivo anthelmintic activity in gerbils and sheep infected by haemonchus contortus |
| publisher |
Springer Nature |
| publishDate |
2022 |
| url |
http://hdl.handle.net/10261/279547 http://dx.doi.org/10.13039/501100014180 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100003329 |
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