Dietary administration of L-carnitine during the fattening period of early feed restricted lambs modifies ruminal fermentation but does not improve feed efficiency

Martín, Alba; Giráldez, Francisco Javier; Cremonesi, P.; Castiglioni, B.; Biscarini, F.; Ceciliani, F.; Santos, Nuria; Andrés, Sonia; Agencia Estatal de Investigación (España)

Dietary administration of L-carnitine during the fattening period of early feed restricted lambs modifies ruminal fermentation but does not improve feed efficiency

15 páginas, 9 tablas, 2 figuras.

Saved in:

Bibliographic Details
Main Authors:	Martín, Alba, Giráldez, Francisco Javier, Cremonesi, P., Castiglioni, B., Biscarini, F., Ceciliani, F., Santos, Nuria, Andrés, Sonia
Other Authors:	Agencia Estatal de Investigación (España)
Format:	artículo biblioteca
Language:	English
Published:	Frontiers Media 2022
Subjects:	Feed efficiency, Lamb, Residual feed intake, L-Carnitine, Ruminal fermentation, Microbiota, Feed restriction, Nutritional programming,
Online Access:	http://hdl.handle.net/10261/269320 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100011033 http://dx.doi.org/10.13039/501100000780
Tags:	Add Tag No Tags, Be the first to tag this record!

id	dig-igm-es-10261-269320
record_format	koha
spelling	dig-igm-es-10261-2693202022-05-12T01:44:19Z Dietary administration of L-carnitine during the fattening period of early feed restricted lambs modifies ruminal fermentation but does not improve feed efficiency Martín, Alba Giráldez, Francisco Javier Cremonesi, P. Castiglioni, B. Biscarini, F. Ceciliani, F. Santos, Nuria Andrés, Sonia Agencia Estatal de Investigación (España) Ministerio de Ciencia e Innovación (España) European Commission Giráldez, Francisco Javier [0000-0002-0680-1541] Andrés, Sonia [0000-0001-5255-1582] Santos Antón, Nuria [0000-0002-8802-3535] Feed efficiency Lamb Residual feed intake L-Carnitine Ruminal fermentation Microbiota Feed restriction Nutritional programming 15 páginas, 9 tablas, 2 figuras. Early feed restriction of lambs may program animals to achieve reduced feed efficiency traits as a consequence of permanent mitochondrial dysfunction. The hypothesis at the background of the present study is that dietary administration of L-Carnitine (a compound that promotes the activation and transportation of fatty acids into the mitochondria) during the fattening period of early feed restricted lambs can: (a) improve the biochemical profile of early feed restricted lambs, (b) improve feed efficiency, (c) modulate the ruminal and intestinal microbiota, and (d) induce changes in the gastrointestinal mucosa, including the immune status. Twenty-two newborn male Merino lambs were raised under natural conditions but separated from the dams for 9h daily to allow feed restriction during the suckling period. At weaning, lambs were assigned to a control group being fed ad libitum a complete pelleted diet during the fattening phase (CTRL, n=11), whereas the second group (CARN, n=11) received the same diet supplemented with 3g of L-Carnitine/kg diet. The results revealed that even though L-Carnitine was absorbed, feed efficiency was not modified by dietary L-Carnitine during the fattening period (residual feed intake, p > 0.05), whereas ruminal fermentation was improved [total short-chain fatty acids (SCFAs), 113 vs. 154mmol/l; p=0.036]. Moreover, a trend toward increased concentration of butyrate in the ileal content (0.568 vs. 1.194 mmol/100 ml SCFA; p = 0.074) was observed. Other effects, such as reduced heart weight, lower levels of markers related to muscle metabolism or damage, improved renal function, and increased ureagenesis, were detected in the CARN group. Limited changes in the microbiota were also detected. These findings suggest that L-Carnitine may improve ruminal fermentation parameters and maintain both the balance of gut microbiota and the health of the animals. However, the improved ruminal fermentation and the consequent greater accumulation of intramuscular fat might have hidden the effects caused by the ability of dietary L-Carnitine to increase fatty acid oxidation at the mitochondrial level. This would explain the lack of effects of L-Carnitine supplementation on feed efficiency and points toward the need of testing lower doses, probably in the context of animals being fed in excess non-protein nitrogen. This work was funded by Ministerio de Ciencia e Innovación (RTI2018-099329-B-I00, MCIN/AEI/10.13039/501100011033, “FEDER, Una manera de hacer Europa”). Peer reviewed 2022-05-11T10:44:24Z 2022-05-11T10:44:24Z 2022 artículo http://purl.org/coar/resource_type/c_6501 Frontiers in Physiology, 13: 840065 http://hdl.handle.net/10261/269320 1664-042X http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100011033 http://dx.doi.org/10.13039/501100000780 en #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-099329-B-I00/ES/PROGRAMACION METABOLICA EN EL GANADO OVINO Y MANEJO DE LA ALIMENTACION PARA ALIVIAR LOS EFECTOS NEGATIVOS OCASIONADOS POR LA RESTRICCION DE ALIMENTO DURANTE LA LACTANCIA/ info:eu-repo/grantAgreement/AEI//10.13039/501100011033 Publisher's version http://dx.doi.org/10.3389/fphys.2022.840065 Sí open Frontiers Media
institution	IGM ES
collection	DSpace
country	España
countrycode	ES
component	Bibliográfico
access	En linea
databasecode	dig-igm-es
tag	biblioteca
region	Europa del Sur
libraryname	Biblioteca del IGM España
language	English
topic	Feed efficiency Lamb Residual feed intake L-Carnitine Ruminal fermentation Microbiota Feed restriction Nutritional programming Feed efficiency Lamb Residual feed intake L-Carnitine Ruminal fermentation Microbiota Feed restriction Nutritional programming
spellingShingle	Feed efficiency Lamb Residual feed intake L-Carnitine Ruminal fermentation Microbiota Feed restriction Nutritional programming Feed efficiency Lamb Residual feed intake L-Carnitine Ruminal fermentation Microbiota Feed restriction Nutritional programming Martín, Alba Giráldez, Francisco Javier Cremonesi, P. Castiglioni, B. Biscarini, F. Ceciliani, F. Santos, Nuria Andrés, Sonia Dietary administration of L-carnitine during the fattening period of early feed restricted lambs modifies ruminal fermentation but does not improve feed efficiency
description	15 páginas, 9 tablas, 2 figuras.
author2	Agencia Estatal de Investigación (España)
author_facet	Agencia Estatal de Investigación (España) Martín, Alba Giráldez, Francisco Javier Cremonesi, P. Castiglioni, B. Biscarini, F. Ceciliani, F. Santos, Nuria Andrés, Sonia
format	artículo
topic_facet	Feed efficiency Lamb Residual feed intake L-Carnitine Ruminal fermentation Microbiota Feed restriction Nutritional programming
author	Martín, Alba Giráldez, Francisco Javier Cremonesi, P. Castiglioni, B. Biscarini, F. Ceciliani, F. Santos, Nuria Andrés, Sonia
author_sort	Martín, Alba
title	Dietary administration of L-carnitine during the fattening period of early feed restricted lambs modifies ruminal fermentation but does not improve feed efficiency
title_short	Dietary administration of L-carnitine during the fattening period of early feed restricted lambs modifies ruminal fermentation but does not improve feed efficiency
title_full	Dietary administration of L-carnitine during the fattening period of early feed restricted lambs modifies ruminal fermentation but does not improve feed efficiency
title_fullStr	Dietary administration of L-carnitine during the fattening period of early feed restricted lambs modifies ruminal fermentation but does not improve feed efficiency
title_full_unstemmed	Dietary administration of L-carnitine during the fattening period of early feed restricted lambs modifies ruminal fermentation but does not improve feed efficiency
title_sort	dietary administration of l-carnitine during the fattening period of early feed restricted lambs modifies ruminal fermentation but does not improve feed efficiency
publisher	Frontiers Media
publishDate	2022
url	http://hdl.handle.net/10261/269320 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100011033 http://dx.doi.org/10.13039/501100000780
work_keys_str_mv	AT martinalba dietaryadministrationoflcarnitineduringthefatteningperiodofearlyfeedrestrictedlambsmodifiesruminalfermentationbutdoesnotimprovefeedefficiency AT giraldezfranciscojavier dietaryadministrationoflcarnitineduringthefatteningperiodofearlyfeedrestrictedlambsmodifiesruminalfermentationbutdoesnotimprovefeedefficiency AT cremonesip dietaryadministrationoflcarnitineduringthefatteningperiodofearlyfeedrestrictedlambsmodifiesruminalfermentationbutdoesnotimprovefeedefficiency AT castiglionib dietaryadministrationoflcarnitineduringthefatteningperiodofearlyfeedrestrictedlambsmodifiesruminalfermentationbutdoesnotimprovefeedefficiency AT biscarinif dietaryadministrationoflcarnitineduringthefatteningperiodofearlyfeedrestrictedlambsmodifiesruminalfermentationbutdoesnotimprovefeedefficiency AT cecilianif dietaryadministrationoflcarnitineduringthefatteningperiodofearlyfeedrestrictedlambsmodifiesruminalfermentationbutdoesnotimprovefeedefficiency AT santosnuria dietaryadministrationoflcarnitineduringthefatteningperiodofearlyfeedrestrictedlambsmodifiesruminalfermentationbutdoesnotimprovefeedefficiency AT andressonia dietaryadministrationoflcarnitineduringthefatteningperiodofearlyfeedrestrictedlambsmodifiesruminalfermentationbutdoesnotimprovefeedefficiency
_version_	1777664110377304064

Dietary administration of L-carnitine during the fattening period of early feed restricted lambs modifies ruminal fermentation but does not improve feed efficiency

Similar Items

Resource Map