Differences Within Churra Breed Sheep in the Early Immune Response to the Infection by Teladorsagia circumcincta

Differences Within Churra Breed Sheep in the Early Immune Response to the Infection by Teladorsagia circumcincta

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Trabajo presentado al: 27th International Conference of the World Association for the Advancement of Veterinary Parasitology. Abstract book, Oral Session OA41.05, pp. 155. Madison (USA), 7-11 julio 2019.

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Main Authors: Castilla Gómez de Agüero, Verónica, Valderas García, Elora, Gutiérrez Gil, B., Arranz, Juan José, González, Jorge, Hernández, J., Martínez Valladares, María
Format: comunicación de congreso biblioteca
Language:English
Published: 2019
Online Access:http://hdl.handle.net/10261/206460
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spelling dig-igm-es-10261-2064602022-12-14T15:57:56Z Differences Within Churra Breed Sheep in the Early Immune Response to the Infection by Teladorsagia circumcincta Castilla Gómez de Agüero, Verónica Valderas García, Elora Gutiérrez Gil, B. Arranz, Juan José González, Jorge Hernández, J. Martínez Valladares, María Trabajo presentado al: 27th International Conference of the World Association for the Advancement of Veterinary Parasitology. Abstract book, Oral Session OA41.05, pp. 155. Madison (USA), 7-11 julio 2019. In the present study, the mechanisms by which Churra breed sheep can present di@erent resistance phenotypes were studied in adults during the early stage of the infection by Teladorsagia circumcincta. For that, 12 animals were classified as resistant (6) or susceptible (6) to the infection by T. circumcincta based on their cumulative faecal egg count after an initial experimental infection. A negative correlation was found between the cumulative FEC at the end of the infection and the level of IgA in serum at day 3 pi (r=-0.764; P= 0.004), when IgAs reached the highest values in the resistant group. Sheep were dewormed and were infected again to be slaughtered at day 7 post infection. At slaughter, level of IgA in serum and gastric mucus was higher in the resistant group although only showing slight significant di@erences in serum samples (P=0.1). At the necropsy, abomasum tissue samples were collected for histological and immunohistochemistry analysis. A positive correlation was found between CD4+ and %&+ T cells (r= 0.714; P= 0.04), suggesting that both cell populations could participate in the early immune response. Moreover, we found an association between the number of %&+ T cells and eosinophils (r= 0.600; P=0.05); this association was even stronger in the resistant group (r= 0.900; P= 0.037), but absent in the susceptible animals, suggesting that the activation of this mechanism could play an important role in the resistance to the infection. On the other hand, the susceptible group showed a negative correlation between globule leukocytes and %&+ T cells (r= -0.812; P=0.05) but also slight with CD4+ T cells (r= -0.800; P=0.1). Therefore, it is possible that in the susceptible group the immune response was not strong enough to activate the recruitment of a higher number of globule leukocytes to protect against the infection. Peer reviewed 2020-04-03T11:38:58Z 2020-04-03T11:38:58Z 2019 comunicación de congreso http://purl.org/coar/resource_type/c_5794 27th International Conference of the World Association for the Advancement of Veterinary Parasitology: 155 (2019). http://hdl.handle.net/10261/206460 en Sí open
institution IGM ES
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country España
countrycode ES
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libraryname Biblioteca del IGM España
language English
description Trabajo presentado al: 27th International Conference of the World Association for the Advancement of Veterinary Parasitology. Abstract book, Oral Session OA41.05, pp. 155. Madison (USA), 7-11 julio 2019.
format comunicación de congreso
author Castilla Gómez de Agüero, Verónica
Valderas García, Elora
Gutiérrez Gil, B.
Arranz, Juan José
González, Jorge
Hernández, J.
Martínez Valladares, María
spellingShingle Castilla Gómez de Agüero, Verónica
Valderas García, Elora
Gutiérrez Gil, B.
Arranz, Juan José
González, Jorge
Hernández, J.
Martínez Valladares, María
Differences Within Churra Breed Sheep in the Early Immune Response to the Infection by Teladorsagia circumcincta
author_facet Castilla Gómez de Agüero, Verónica
Valderas García, Elora
Gutiérrez Gil, B.
Arranz, Juan José
González, Jorge
Hernández, J.
Martínez Valladares, María
author_sort Castilla Gómez de Agüero, Verónica
title Differences Within Churra Breed Sheep in the Early Immune Response to the Infection by Teladorsagia circumcincta
title_short Differences Within Churra Breed Sheep in the Early Immune Response to the Infection by Teladorsagia circumcincta
title_full Differences Within Churra Breed Sheep in the Early Immune Response to the Infection by Teladorsagia circumcincta
title_fullStr Differences Within Churra Breed Sheep in the Early Immune Response to the Infection by Teladorsagia circumcincta
title_full_unstemmed Differences Within Churra Breed Sheep in the Early Immune Response to the Infection by Teladorsagia circumcincta
title_sort differences within churra breed sheep in the early immune response to the infection by teladorsagia circumcincta
publishDate 2019
url http://hdl.handle.net/10261/206460
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