Current and promising novel drug candidates against visceral leishmaniasis
20 páginas, 2 tablas, 4 figuras.
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| Format: | artículo biblioteca |
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International Union of Pure and Applied Chemistry
2019
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| Subjects: | Drug discovery, Neglected tropical diseases, NTD2018, Pharmacology, Visceral leishmaniasis, |
| Online Access: | http://hdl.handle.net/10261/204486 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100014180 |
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dig-igm-es-10261-2044862022-09-06T07:15:01Z Current and promising novel drug candidates against visceral leishmaniasis Reguera, R.M. Perez-Pertejo, Y. Gutiérrez-Corbo, C. Domínguez-Asenjo, Bárbara Ordonez, C. García Estrada, Carlos Martínez Valladares, María Balaña-Fouce, Rafael Ministerio de Economía y Competitividad (España) European Commission Junta de Castilla y León Drug discovery Neglected tropical diseases NTD2018 Pharmacology Visceral leishmaniasis 20 páginas, 2 tablas, 4 figuras. Leishmaniasis is a group of zoonotic diseases caused by a trypanosomatid parasite mostly in impoverished populations of low-income countries. In their different forms, leishmaniasis is prevalent in more than 98 countries all over the world and approximately 360-million people are at risk. Since no vaccine is currently available to prevent any form of the disease, the control strategy of leishmaniasis mainly relies on early case detection followed by adequate pharmacological treatment that may improve the prognosis and can reduce transmission. A handful of compounds and formulations are available for the treatment of leishmaniasis in humans, but only few of them are currently in use since most of these agents are associated with toxicity problems such as nephrotoxicity and cardiotoxicity in addition to resistance problems. In recent decades, very few novel drugs, new formulations of standard drugs or combinations of them have been approved against leishmaniasis. This review highlights the current drugs and combinations that are used medical practice and recent advances in new treatments against leishmaniasis that were pointed out in the recent 2nd Conference, Global Challenges in Neglected Tropical Diseases, held in San Juan, Puerto Rico in June 2018, emphasizing the plethora of new families of molecules that are bridging the gap between preclinical and first-in-man trials in next future. Financial support from the Ministerio de Economía y Competitividad (MINECO, AEI, FEDER, UE) [MINECO, Funder Id: http://dx.doi.org/10.13039/501100003329, AGL2016-79813-C2-1R and Funder Id: http://dx.doi.org/10.13039/501100003329, SAF2017-83575-R], and the Junta de Castilla y León co-financed by FEDER, UE [LE020P17] is gratefully acknowledged. CGC and BGA are supported by scholarships from the Junta de Castilla y León co-financed by FEDER. 2020-03-19T11:15:18Z 2020-03-19T11:15:18Z 2019 2020-03-19T11:15:18Z artículo http://purl.org/coar/resource_type/c_6501 doi: 10.1515/pac-2018-1102 issn: 0033-4545 Pure and Applied Chemistry 91: 1385- 1404 (2019) http://hdl.handle.net/10261/204486 10.1515/pac-2018-1102 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100014180 #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2016-79813-C2-1-R Publisher's version http://dx.doi.org/10.1515/pac-2018-1102 Sí open International Union of Pure and Applied Chemistry |
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Drug discovery Neglected tropical diseases NTD2018 Pharmacology Visceral leishmaniasis Drug discovery Neglected tropical diseases NTD2018 Pharmacology Visceral leishmaniasis |
| spellingShingle |
Drug discovery Neglected tropical diseases NTD2018 Pharmacology Visceral leishmaniasis Drug discovery Neglected tropical diseases NTD2018 Pharmacology Visceral leishmaniasis Reguera, R.M. Perez-Pertejo, Y. Gutiérrez-Corbo, C. Domínguez-Asenjo, Bárbara Ordonez, C. García Estrada, Carlos Martínez Valladares, María Balaña-Fouce, Rafael Current and promising novel drug candidates against visceral leishmaniasis |
| description |
20 páginas, 2 tablas, 4 figuras. |
| author2 |
Ministerio de Economía y Competitividad (España) |
| author_facet |
Ministerio de Economía y Competitividad (España) Reguera, R.M. Perez-Pertejo, Y. Gutiérrez-Corbo, C. Domínguez-Asenjo, Bárbara Ordonez, C. García Estrada, Carlos Martínez Valladares, María Balaña-Fouce, Rafael |
| format |
artículo |
| topic_facet |
Drug discovery Neglected tropical diseases NTD2018 Pharmacology Visceral leishmaniasis |
| author |
Reguera, R.M. Perez-Pertejo, Y. Gutiérrez-Corbo, C. Domínguez-Asenjo, Bárbara Ordonez, C. García Estrada, Carlos Martínez Valladares, María Balaña-Fouce, Rafael |
| author_sort |
Reguera, R.M. |
| title |
Current and promising novel drug candidates against visceral leishmaniasis |
| title_short |
Current and promising novel drug candidates against visceral leishmaniasis |
| title_full |
Current and promising novel drug candidates against visceral leishmaniasis |
| title_fullStr |
Current and promising novel drug candidates against visceral leishmaniasis |
| title_full_unstemmed |
Current and promising novel drug candidates against visceral leishmaniasis |
| title_sort |
current and promising novel drug candidates against visceral leishmaniasis |
| publisher |
International Union of Pure and Applied Chemistry |
| publishDate |
2019 |
| url |
http://hdl.handle.net/10261/204486 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100014180 |
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