Intoxication of sheep with quebracho tannin extract
11 pages, 4 figures, 3 tables.-- PMID: 12859907 [PubMed].-- Printed version published Jul 2003.
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| Format: | artículo biblioteca |
| Language: | English |
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Elsevier
2003
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| Subjects: | Quebracho tannin, Sheep, Tannin intoxication, |
| Online Access: | http://hdl.handle.net/10261/10827 |
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dig-igm-es-10261-108272021-04-13T15:28:35Z Intoxication of sheep with quebracho tannin extract Hervás, Gonzalo Pérez Pérez, Valentín Giráldez, Francisco Javier Mantecón, Ángel R. Almar, M. M. Frutos, Pilar Quebracho tannin Sheep Tannin intoxication 11 pages, 4 figures, 3 tables.-- PMID: 12859907 [PubMed].-- Printed version published Jul 2003. This experiment was carried out to study the toxicity of quebracho tannin extract (containing 760 g of condensed tannins [CTs] per kg), with the aim of validating its use as a feed additive for improving the digestive utilization of protein-rich feeds. Four groups (Q(0), Q(1), Q(2) and Q(3)) of four sheep were dosed intra-ruminally once daily, for up to 21 days with, respectively, 0, 0.5, 1.5 or 3.0 g quebracho tannin extract/kg live-weight (LW). Feed intake, live-weight changes, plasma biochemistry, indicators of hepatic detoxification function, gross lesions and histopathology were examined. Animals in groups Q(0), Q(1) and Q(2) consumed all the offered feed. In contrast, feed intake was practically nil after 6 days of quebracho dosing in group Q(3), this being associated with a loss of 4.7+/-1.30 kg LW in 10 days (P<0.05). Sheep from groups Q(0), Q(1) and Q(2) remained healthy throughout the experiment. Ewes from group Q(3) became weak and depressed on day 5 and after 8 days of dosing remained recumbent. They were humanely killed after 10 days to avoid suffering. In general, neither gross lesions nor microscopical changes were observed in animals from groups Q(0), Q(1) and Q(2). However, Q(3) sheep showed striking lesions in the digestive tract (well-demarcated ulcers filled with necrotic material in the mucosa of the rumen and reticulum, distension of abomasum and small intestine, and dense mucous material in the caecum), and changes in plasma biochemistry. Cytochrome P-450 and glutathione concentrations were significantly reduced in Q(3) sheep (P<0.05). It is concluded that quebracho tannin extract is not toxic for ruminants, except in concentrations too high to be encountered under practical conditions. This work was supported by the Inter-ministerial Commission of Science and Technology (CICYT) of Spain (Project AGF98-0874). G. Hervás gratefully acknowledges receipt of a fellowship from the Spanish Ministries of Education and Culture (MEC) and Science and Technology (MCyT). Peer reviewed 2009-02-19T11:26:33Z 2009-02-19T11:26:33Z 2003 artículo http://purl.org/coar/resource_type/c_6501 Journal of Comparative Pathology 129(1): 44-54 (2003) 0021-9975 http://hdl.handle.net/10261/10827 10.1016/S0021-9975(02)00168-8 en http://dx.doi.org/10.1016/S0021-9975(02)00168-8 open 94510 bytes application/pdf Elsevier |
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Quebracho tannin Sheep Tannin intoxication Quebracho tannin Sheep Tannin intoxication |
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Quebracho tannin Sheep Tannin intoxication Quebracho tannin Sheep Tannin intoxication Hervás, Gonzalo Pérez Pérez, Valentín Giráldez, Francisco Javier Mantecón, Ángel R. Almar, M. M. Frutos, Pilar Intoxication of sheep with quebracho tannin extract |
| description |
11 pages, 4 figures, 3 tables.-- PMID: 12859907 [PubMed].-- Printed version published Jul 2003. |
| format |
artículo |
| topic_facet |
Quebracho tannin Sheep Tannin intoxication |
| author |
Hervás, Gonzalo Pérez Pérez, Valentín Giráldez, Francisco Javier Mantecón, Ángel R. Almar, M. M. Frutos, Pilar |
| author_facet |
Hervás, Gonzalo Pérez Pérez, Valentín Giráldez, Francisco Javier Mantecón, Ángel R. Almar, M. M. Frutos, Pilar |
| author_sort |
Hervás, Gonzalo |
| title |
Intoxication of sheep with quebracho tannin extract |
| title_short |
Intoxication of sheep with quebracho tannin extract |
| title_full |
Intoxication of sheep with quebracho tannin extract |
| title_fullStr |
Intoxication of sheep with quebracho tannin extract |
| title_full_unstemmed |
Intoxication of sheep with quebracho tannin extract |
| title_sort |
intoxication of sheep with quebracho tannin extract |
| publisher |
Elsevier |
| publishDate |
2003 |
| url |
http://hdl.handle.net/10261/10827 |
| work_keys_str_mv |
AT hervasgonzalo intoxicationofsheepwithquebrachotanninextract AT perezperezvalentin intoxicationofsheepwithquebrachotanninextract AT giraldezfranciscojavier intoxicationofsheepwithquebrachotanninextract AT manteconangelr intoxicationofsheepwithquebrachotanninextract AT almarmm intoxicationofsheepwithquebrachotanninextract AT frutospilar intoxicationofsheepwithquebrachotanninextract |
| _version_ |
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