Cytokine expression in the placenta of pregnant cattle after inoculation with Neospora caninum
13 páginas, 4 tablas, 2 figuras.
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| Format: | artículo biblioteca |
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Elsevier
2014
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| Subjects: | Neospora caninum, Placenta, Cytokines, Cattle, |
| Online Access: | http://hdl.handle.net/10261/102545 http://dx.doi.org/10.13039/501100010677 |
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dig-igm-es-10261-1025452018-08-27T09:12:58Z Cytokine expression in the placenta of pregnant cattle after inoculation with Neospora caninum Cantón, Germán J. Katzer, Frank Maley, Stephen W. Bartley, Paul M. Benavides, Julio Palarea-Albaladejo, Javier Pang, Yvonne Smith, Sionagh Rocchi, Mara S. Buxton, David Innes, Elisabeth A. Chianini, F. Scottish Government's Rural and Environment Science and Analytical Services Instituto Nacional de Tecnología Agropecuaria (Argentina) Neospora caninum Placenta Cytokines Cattle 13 páginas, 4 tablas, 2 figuras. Neospora caninum is recognized as a major cause of reproductive losses worldwide but its pathogenesis is not completely understood. Immune mediated placental pathology has been reported as being responsible for compromising pregnancy probably due to the adverse effects of exacerbated Th1 type response at the maternal-foetal interface. Different clinical outcomes are known to occur following experimental infections of cattle at different stages of gestation, with foetal death being the most common finding during early gestation, and the birth of live congenitally infected calves following infection later in gestation. The aim of the current study was to characterize the cytokine expression in the placenta of cattle experimentally challenged with tachyzoites of the Nc-1 strain during early, mid and late gestation. Moderate to severe infiltration of IL-12, IFN-γ and TNF-α expressing cells was observed in the placentas collected at early gestation and this infiltration was more pronounced in the samples collected from challenged dams carrying non-viable foetuses, compared with the mothers carrying viable foetuses. In contrast, the infiltration of Th1 cytokine expressing-cells was mild following N. caninum infection in mid gestation and scarce during infection in late gestation. Scarce expression of IL-4 was observed in the placentas from N. caninum-challenged and negative control animals throughout gestation. The milder Th1 immune response observed during later stages of gestation following Nc-1 infection could partially explain the less severe clinical outcome when compared to early pregnancy. © 2014 Elsevier B.V. The authors acknowledge the Scottish Government's Rural and Environment Science and Analytical Services Division (RESAS), UK, and Instituto Nacional de Tecnología Agropecuaria (INTA), Argentina. Peer Reviewed 2014-09-26T10:18:12Z 2014-09-26T10:18:12Z 2014 2014-09-26T10:18:12Z artículo http://purl.org/coar/resource_type/c_6501 Veterinary immunology and immunopathology 161: 77- 89 (2014) 1873-2534 http://hdl.handle.net/10261/102545 10.1016/j.vetimm.2014.07.004 http://dx.doi.org/10.13039/501100010677 http://dx.doi.org/10.1016/j.vetimm.2014.07.004 none Elsevier |
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Neospora caninum Placenta Cytokines Cattle Neospora caninum Placenta Cytokines Cattle |
| spellingShingle |
Neospora caninum Placenta Cytokines Cattle Neospora caninum Placenta Cytokines Cattle Cantón, Germán J. Katzer, Frank Maley, Stephen W. Bartley, Paul M. Benavides, Julio Palarea-Albaladejo, Javier Pang, Yvonne Smith, Sionagh Rocchi, Mara S. Buxton, David Innes, Elisabeth A. Chianini, F. Cytokine expression in the placenta of pregnant cattle after inoculation with Neospora caninum |
| description |
13 páginas, 4 tablas, 2 figuras. |
| author2 |
Scottish Government's Rural and Environment Science and Analytical Services |
| author_facet |
Scottish Government's Rural and Environment Science and Analytical Services Cantón, Germán J. Katzer, Frank Maley, Stephen W. Bartley, Paul M. Benavides, Julio Palarea-Albaladejo, Javier Pang, Yvonne Smith, Sionagh Rocchi, Mara S. Buxton, David Innes, Elisabeth A. Chianini, F. |
| format |
artículo |
| topic_facet |
Neospora caninum Placenta Cytokines Cattle |
| author |
Cantón, Germán J. Katzer, Frank Maley, Stephen W. Bartley, Paul M. Benavides, Julio Palarea-Albaladejo, Javier Pang, Yvonne Smith, Sionagh Rocchi, Mara S. Buxton, David Innes, Elisabeth A. Chianini, F. |
| author_sort |
Cantón, Germán J. |
| title |
Cytokine expression in the placenta of pregnant cattle after inoculation with Neospora caninum |
| title_short |
Cytokine expression in the placenta of pregnant cattle after inoculation with Neospora caninum |
| title_full |
Cytokine expression in the placenta of pregnant cattle after inoculation with Neospora caninum |
| title_fullStr |
Cytokine expression in the placenta of pregnant cattle after inoculation with Neospora caninum |
| title_full_unstemmed |
Cytokine expression in the placenta of pregnant cattle after inoculation with Neospora caninum |
| title_sort |
cytokine expression in the placenta of pregnant cattle after inoculation with neospora caninum |
| publisher |
Elsevier |
| publishDate |
2014 |
| url |
http://hdl.handle.net/10261/102545 http://dx.doi.org/10.13039/501100010677 |
| work_keys_str_mv |
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