Variation in the immuno-pathological responses of lambs after experimental infection with different strains of Mycobacterium avium subsp paratuberculosis
10 páginas, 5 figuras, 2 tablas.
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Blackwell Publishing
2007
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Subjects: | Granuloma, Pathogenesis, Paratuberculosis lesions, Mycobacterium avium subsp. paratuberculosis, Lambs, Strains, |
Online Access: | http://hdl.handle.net/10261/100096 |
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dig-igm-es-10261-1000962021-04-13T15:44:40Z Variation in the immuno-pathological responses of lambs after experimental infection with different strains of Mycobacterium avium subsp paratuberculosis Verna, A. García Pariente, C. Muñoz, María Moreno, O. García Marín, Juan Francisco Romano, M. I. Paolicchi, F. Pérez Pérez, Valentín Granuloma Pathogenesis Paratuberculosis lesions Mycobacterium avium subsp. paratuberculosis Lambs Strains 10 páginas, 5 figuras, 2 tablas. Ruminant infection by Mycobacterium avium subsp. paratuberculosis (MAP) causes a granulomatous inflammatory response in the intestine and associated lymph nodes. Differences either in the affected organs or in the inflammatory infiltrate were observed between species and individuals. Such differences are usually attributed to variations in host immune responses or to inconsistent effects among different MAP strains. To evaluate if different MAP strains induce different immuno-pathological responses in lambs, 28 one-month-old individuals were divided into six groups and inoculated with different MAP strains. Groups 1 and 2 were inoculated with two bovine strains isolated in Argentina that showed different genetic patterns after BstEII-IS900-RFLP (hereafter strains E and A respectively). Group 3 was inoculated with a bovine strain isolated in Spain obtained after a previous step of culture (patterns C1). Group 4 was inoculated with a homogenate of intestinal mucosa of a clinical case affected by the same bovine strain as that of group 3. Group 5 was inoculated with an ovine strain that was directly purified from the intestinal mucosa of a clinical case, and group 6 was kept as control (i.e. no inoculation). Peripheral immune responses were assessed until 150 days post-infection (dpi), when lambs were humanely killed. Pathological studies were performed in tissues from the intestine and lymph nodes. Lesion types and inflammatory infiltrates were examined as indicators of pathogenicity. All the lambs infected with bovine MAP strains showed a common lesion pattern regardless of the strain type. Such pattern was characterized by focal lesions mainly in the mesenteric lymph nodes, the presence of fibrous tissue, and, occasionally, necrosis in the granulomas as well as the presence of numerous giant cells. Differences in lesion severity were observed among groups: lambs from groups 1 and 2 had the highest number of granulomas and the largest lymph node area affected. Lesions in animals from group 5 (infected with an ovine strain) were more severe and occurred mostly in the intestinal lymphoid tissue; necrosis, fibrosis or giant cells were never detected in this group. These results indicate that the MAP strain type induces different pathological responses in lambs. Financial support was provided by project No AGL-2004- 07421-C0201 from ‘Ministerio de Education y Ciencia’ of Spain and National Scientific and Technological Research Council. Peer Reviewed 2014-07-17T11:16:28Z 2014-07-17T11:16:28Z 2007 2014-07-17T11:16:28Z artículo http://purl.org/coar/resource_type/c_6501 Zoonoses and Public Health 54: 243- 252 (2007) 1863-1959 http://hdl.handle.net/10261/100096 10.1111/j.1863-2378.2007.01058.x http://dx.doi.org/10.1111/j.1863-2378.2007.01058.x none Blackwell Publishing |
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Granuloma Pathogenesis Paratuberculosis lesions Mycobacterium avium subsp. paratuberculosis Lambs Strains Granuloma Pathogenesis Paratuberculosis lesions Mycobacterium avium subsp. paratuberculosis Lambs Strains |
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Granuloma Pathogenesis Paratuberculosis lesions Mycobacterium avium subsp. paratuberculosis Lambs Strains Granuloma Pathogenesis Paratuberculosis lesions Mycobacterium avium subsp. paratuberculosis Lambs Strains Verna, A. García Pariente, C. Muñoz, María Moreno, O. García Marín, Juan Francisco Romano, M. I. Paolicchi, F. Pérez Pérez, Valentín Variation in the immuno-pathological responses of lambs after experimental infection with different strains of Mycobacterium avium subsp paratuberculosis |
description |
10 páginas, 5 figuras, 2 tablas. |
format |
artículo |
topic_facet |
Granuloma Pathogenesis Paratuberculosis lesions Mycobacterium avium subsp. paratuberculosis Lambs Strains |
author |
Verna, A. García Pariente, C. Muñoz, María Moreno, O. García Marín, Juan Francisco Romano, M. I. Paolicchi, F. Pérez Pérez, Valentín |
author_facet |
Verna, A. García Pariente, C. Muñoz, María Moreno, O. García Marín, Juan Francisco Romano, M. I. Paolicchi, F. Pérez Pérez, Valentín |
author_sort |
Verna, A. |
title |
Variation in the immuno-pathological responses of lambs after experimental infection with different strains of Mycobacterium avium subsp paratuberculosis |
title_short |
Variation in the immuno-pathological responses of lambs after experimental infection with different strains of Mycobacterium avium subsp paratuberculosis |
title_full |
Variation in the immuno-pathological responses of lambs after experimental infection with different strains of Mycobacterium avium subsp paratuberculosis |
title_fullStr |
Variation in the immuno-pathological responses of lambs after experimental infection with different strains of Mycobacterium avium subsp paratuberculosis |
title_full_unstemmed |
Variation in the immuno-pathological responses of lambs after experimental infection with different strains of Mycobacterium avium subsp paratuberculosis |
title_sort |
variation in the immuno-pathological responses of lambs after experimental infection with different strains of mycobacterium avium subsp paratuberculosis |
publisher |
Blackwell Publishing |
publishDate |
2007 |
url |
http://hdl.handle.net/10261/100096 |
work_keys_str_mv |
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