Anaerobic co-metabolic biodegradation of pharmaceuticals and personal care products driven by glycerol fermentation
Anaerobic digestion in two sequential phases, acidogenesis and methanogenesis, has been shown to be beneficial for enhancing the biomethane generation from wastewater. In this work, the application of glycerol (GOH) as a fermentation co-substrate during the wastewater treatment was evaluated on the biodegradation of different pharmaceuticals and personal care products (PPCPs). GOH co-digestion during acidogenesis led to a significant increase in the biodegradation of acetaminophen (from 78 to 89%), ciprofloxacin (from 25 to 46%), naproxen (from 73 to 86%), diclofenac (from 36 to 48%), ibuprofen (from 65 to 88%), metoprolol (from 45 to 59%), methylparaben (from 64 to 78%) and propylparaben (from 68 to 74%). The heterotrophic co-metabolism of PPCPs driven by glycerol was confirmed by the biodegradation kinetics, in which kbio (biodegradation kinetics constant) values increased from 0.18 to 2.11 to 0.27-3.60 L g-1-VSS d-1, for the operational phases without and with GOH, respectively. The assessment of metabolic pathways in each phase revealed that the prevalence of aromatic compounds degradation, metabolism of xenobiotics by cytochrome P450, and benzoate degradation routes during acidogenesis are key factors for the enzymatic mechanisms linked to the PPCPs co-metabolism. The phase separation of anaerobic digestion was effective in the PPCPs biodegradation, and the co-fermentation of glycerol provided an increase in the generation potential of biomethane in the system (energetic potential of 5.0 and 6.3 kJ g-1-CODremoved, without and with GOH, respectively). This study showed evidence that glycerol co-fermentation can exert a synergistic effect on the PPCPs removal during anaerobic digestion mediated by heterotrophic co-metabolism.
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2024-04-13
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Subjects: | Organic micropollutants, Anaerobic digestion, Cytochrome P(450), Kinetics, Metabolic pathways, Methane, Ensure healthy lives and promote well-being for all at all ages, Make cities and human settlements inclusive, safe, resilient and sustainable, |
Online Access: | http://hdl.handle.net/10261/354463 https://api.elsevier.com/content/abstract/scopus_id/85190348299 |
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dig-idaea-es-10261-3544632024-05-18T20:38:41Z Anaerobic co-metabolic biodegradation of pharmaceuticals and personal care products driven by glycerol fermentation Carneiro, Rodrigo B. Gomes, Gisele M. Camargo, Franciele P. Zaiat, Marcelo Santos-Neto, Álvaro J. 0000-0002-9188-4133 Organic micropollutants Anaerobic digestion Cytochrome P(450) Kinetics Metabolic pathways Methane Ensure healthy lives and promote well-being for all at all ages Make cities and human settlements inclusive, safe, resilient and sustainable Anaerobic digestion in two sequential phases, acidogenesis and methanogenesis, has been shown to be beneficial for enhancing the biomethane generation from wastewater. In this work, the application of glycerol (GOH) as a fermentation co-substrate during the wastewater treatment was evaluated on the biodegradation of different pharmaceuticals and personal care products (PPCPs). GOH co-digestion during acidogenesis led to a significant increase in the biodegradation of acetaminophen (from 78 to 89%), ciprofloxacin (from 25 to 46%), naproxen (from 73 to 86%), diclofenac (from 36 to 48%), ibuprofen (from 65 to 88%), metoprolol (from 45 to 59%), methylparaben (from 64 to 78%) and propylparaben (from 68 to 74%). The heterotrophic co-metabolism of PPCPs driven by glycerol was confirmed by the biodegradation kinetics, in which kbio (biodegradation kinetics constant) values increased from 0.18 to 2.11 to 0.27-3.60 L g-1-VSS d-1, for the operational phases without and with GOH, respectively. The assessment of metabolic pathways in each phase revealed that the prevalence of aromatic compounds degradation, metabolism of xenobiotics by cytochrome P450, and benzoate degradation routes during acidogenesis are key factors for the enzymatic mechanisms linked to the PPCPs co-metabolism. The phase separation of anaerobic digestion was effective in the PPCPs biodegradation, and the co-fermentation of glycerol provided an increase in the generation potential of biomethane in the system (energetic potential of 5.0 and 6.3 kJ g-1-CODremoved, without and with GOH, respectively). This study showed evidence that glycerol co-fermentation can exert a synergistic effect on the PPCPs removal during anaerobic digestion mediated by heterotrophic co-metabolism. This work was supported by the São Paulo Research Foundation (FAPESP - grant numbers 2022/09239-5, 2021/05052-5, 2019/22532-0, 2017/02147-0, and 2015/06246-7); and the Coordination for the Improvement of Higher Education Personnel (CAPES - Finance Code 001). Peer reviewed 2024-04-22T06:00:16Z 2024-04-22T06:00:16Z 2024-04-13 artículo http://purl.org/coar/resource_type/c_6501 Chemosphere 357: 142006 (2024) 00456535 http://hdl.handle.net/10261/354463 10.1016/j.chemosphere.2024.142006 38621493 2-s2.0-85190348299 https://api.elsevier.com/content/abstract/scopus_id/85190348299 en Chemosphere Postprint https://doi.org/10.1016/j.chemosphere.2024.142006 Sí embargo_20260601 Elsevier |
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Organic micropollutants Anaerobic digestion Cytochrome P(450) Kinetics Metabolic pathways Methane Ensure healthy lives and promote well-being for all at all ages Make cities and human settlements inclusive, safe, resilient and sustainable Organic micropollutants Anaerobic digestion Cytochrome P(450) Kinetics Metabolic pathways Methane Ensure healthy lives and promote well-being for all at all ages Make cities and human settlements inclusive, safe, resilient and sustainable |
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Organic micropollutants Anaerobic digestion Cytochrome P(450) Kinetics Metabolic pathways Methane Ensure healthy lives and promote well-being for all at all ages Make cities and human settlements inclusive, safe, resilient and sustainable Organic micropollutants Anaerobic digestion Cytochrome P(450) Kinetics Metabolic pathways Methane Ensure healthy lives and promote well-being for all at all ages Make cities and human settlements inclusive, safe, resilient and sustainable Carneiro, Rodrigo B. Gomes, Gisele M. Camargo, Franciele P. Zaiat, Marcelo Santos-Neto, Álvaro J. Anaerobic co-metabolic biodegradation of pharmaceuticals and personal care products driven by glycerol fermentation |
description |
Anaerobic digestion in two sequential phases, acidogenesis and methanogenesis, has been shown to be beneficial for enhancing the biomethane generation from wastewater. In this work, the application of glycerol (GOH) as a fermentation co-substrate during the wastewater treatment was evaluated on the biodegradation of different pharmaceuticals and personal care products (PPCPs). GOH co-digestion during acidogenesis led to a significant increase in the biodegradation of acetaminophen (from 78 to 89%), ciprofloxacin (from 25 to 46%), naproxen (from 73 to 86%), diclofenac (from 36 to 48%), ibuprofen (from 65 to 88%), metoprolol (from 45 to 59%), methylparaben (from 64 to 78%) and propylparaben (from 68 to 74%). The heterotrophic co-metabolism of PPCPs driven by glycerol was confirmed by the biodegradation kinetics, in which kbio (biodegradation kinetics constant) values increased from 0.18 to 2.11 to 0.27-3.60 L g-1-VSS d-1, for the operational phases without and with GOH, respectively. The assessment of metabolic pathways in each phase revealed that the prevalence of aromatic compounds degradation, metabolism of xenobiotics by cytochrome P450, and benzoate degradation routes during acidogenesis are key factors for the enzymatic mechanisms linked to the PPCPs co-metabolism. The phase separation of anaerobic digestion was effective in the PPCPs biodegradation, and the co-fermentation of glycerol provided an increase in the generation potential of biomethane in the system (energetic potential of 5.0 and 6.3 kJ g-1-CODremoved, without and with GOH, respectively). This study showed evidence that glycerol co-fermentation can exert a synergistic effect on the PPCPs removal during anaerobic digestion mediated by heterotrophic co-metabolism. |
author2 |
0000-0002-9188-4133 |
author_facet |
0000-0002-9188-4133 Carneiro, Rodrigo B. Gomes, Gisele M. Camargo, Franciele P. Zaiat, Marcelo Santos-Neto, Álvaro J. |
format |
artículo |
topic_facet |
Organic micropollutants Anaerobic digestion Cytochrome P(450) Kinetics Metabolic pathways Methane Ensure healthy lives and promote well-being for all at all ages Make cities and human settlements inclusive, safe, resilient and sustainable |
author |
Carneiro, Rodrigo B. Gomes, Gisele M. Camargo, Franciele P. Zaiat, Marcelo Santos-Neto, Álvaro J. |
author_sort |
Carneiro, Rodrigo B. |
title |
Anaerobic co-metabolic biodegradation of pharmaceuticals and personal care products driven by glycerol fermentation |
title_short |
Anaerobic co-metabolic biodegradation of pharmaceuticals and personal care products driven by glycerol fermentation |
title_full |
Anaerobic co-metabolic biodegradation of pharmaceuticals and personal care products driven by glycerol fermentation |
title_fullStr |
Anaerobic co-metabolic biodegradation of pharmaceuticals and personal care products driven by glycerol fermentation |
title_full_unstemmed |
Anaerobic co-metabolic biodegradation of pharmaceuticals and personal care products driven by glycerol fermentation |
title_sort |
anaerobic co-metabolic biodegradation of pharmaceuticals and personal care products driven by glycerol fermentation |
publisher |
Elsevier |
publishDate |
2024-04-13 |
url |
http://hdl.handle.net/10261/354463 https://api.elsevier.com/content/abstract/scopus_id/85190348299 |
work_keys_str_mv |
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