Innovative analytical methodologies for characterizing chemical exposure with a view to next-generation risk assessment
The chemical burden on the environment and human population is increasing. Consequently, regulatory risk assessment must keep pace to manage, reduce, and prevent adverse impacts on human and environmental health associated with hazardous chemicals. Surveillance of chemicals of known, emerging, or potential future concern, entering the environment-food-human continuum is needed to document the reality of risks posed by chemicals on ecosystem and human health from a one health perspective, feed into early warning systems and support public policies for exposure mitigation provisions and safe and sustainable by design strategies. The use of less-conventional sampling strategies and integration of full-scan, high-resolution mass spectrometry and effect-directed analysis in environmental and human monitoring programmes have the potential to enhance the screening and identification of a wider range of chemicals of known, emerging or potential future concern. Here, we outline the key needs and recommendations identified within the European Partnership for Assessment of Risks from Chemicals (PARC) project for leveraging these innovative methodologies to support the development of next-generation chemical risk assessment.
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Format: | artículo biblioteca |
Language: | English |
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Elsevier
2024-03-17
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Subjects: | Sampling strategies, Chemical exposure, Chemical risk assessment, Effect-based methods, Effect-directed analysis, High-resolution mass spectrometry, Ensure healthy lives and promote well-being for all at all ages, |
Online Access: | http://hdl.handle.net/10261/352937 http://dx.doi.org/10.13039/501100000780 https://api.elsevier.com/content/abstract/scopus_id/85188785915 |
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Sampling strategies Chemical exposure Chemical risk assessment Effect-based methods Effect-directed analysis High-resolution mass spectrometry Ensure healthy lives and promote well-being for all at all ages Sampling strategies Chemical exposure Chemical risk assessment Effect-based methods Effect-directed analysis High-resolution mass spectrometry Ensure healthy lives and promote well-being for all at all ages |
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Sampling strategies Chemical exposure Chemical risk assessment Effect-based methods Effect-directed analysis High-resolution mass spectrometry Ensure healthy lives and promote well-being for all at all ages Sampling strategies Chemical exposure Chemical risk assessment Effect-based methods Effect-directed analysis High-resolution mass spectrometry Ensure healthy lives and promote well-being for all at all ages Tkalec, Žiga Antignac, Jean-Philippe Bandow, Nicole Béen, Frederic M. Belova, Lidia Bessems, Jos Le Bizec, Bruno Brack, Werner Cano-Sancho, German Chaker, Jade Covaci, Adrian Creusot, Nicolas David, Arthur Debrauwer, Laurent Dervilly, Gaud Duca, Radu Corneliu Fessard, Valérie Grimalt, Joan O. Guerin, Thierry Habchi, Baninia Hecht, Helge Hollender, Juliane Jamin, Emilien L. Klánová, Jana Kosjek, Tina Krauss, Martin Lamoree, Marja Lavison-Bompard, Gwenaelle Meijer, Jeroen Moeller, Ruth Mol, Hans Mompelat, Sophie Van Nieuwenhuyse, An Oberacher, Herbert Parinet, Julien Van Poucke, Christof Roškar, Robert Togola, Anne Trontelj, Jurij Price, Elliott J. Innovative analytical methodologies for characterizing chemical exposure with a view to next-generation risk assessment |
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The chemical burden on the environment and human population is increasing. Consequently, regulatory risk assessment must keep pace to manage, reduce, and prevent adverse impacts on human and environmental health associated with hazardous chemicals. Surveillance of chemicals of known, emerging, or potential future concern, entering the environment-food-human continuum is needed to document the reality of risks posed by chemicals on ecosystem and human health from a one health perspective, feed into early warning systems and support public policies for exposure mitigation provisions and safe and sustainable by design strategies. The use of less-conventional sampling strategies and integration of full-scan, high-resolution mass spectrometry and effect-directed analysis in environmental and human monitoring programmes have the potential to enhance the screening and identification of a wider range of chemicals of known, emerging or potential future concern. Here, we outline the key needs and recommendations identified within the European Partnership for Assessment of Risks from Chemicals (PARC) project for leveraging these innovative methodologies to support the development of next-generation chemical risk assessment. |
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European Commission |
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European Commission Tkalec, Žiga Antignac, Jean-Philippe Bandow, Nicole Béen, Frederic M. Belova, Lidia Bessems, Jos Le Bizec, Bruno Brack, Werner Cano-Sancho, German Chaker, Jade Covaci, Adrian Creusot, Nicolas David, Arthur Debrauwer, Laurent Dervilly, Gaud Duca, Radu Corneliu Fessard, Valérie Grimalt, Joan O. Guerin, Thierry Habchi, Baninia Hecht, Helge Hollender, Juliane Jamin, Emilien L. Klánová, Jana Kosjek, Tina Krauss, Martin Lamoree, Marja Lavison-Bompard, Gwenaelle Meijer, Jeroen Moeller, Ruth Mol, Hans Mompelat, Sophie Van Nieuwenhuyse, An Oberacher, Herbert Parinet, Julien Van Poucke, Christof Roškar, Robert Togola, Anne Trontelj, Jurij Price, Elliott J. |
format |
artículo |
topic_facet |
Sampling strategies Chemical exposure Chemical risk assessment Effect-based methods Effect-directed analysis High-resolution mass spectrometry Ensure healthy lives and promote well-being for all at all ages |
author |
Tkalec, Žiga Antignac, Jean-Philippe Bandow, Nicole Béen, Frederic M. Belova, Lidia Bessems, Jos Le Bizec, Bruno Brack, Werner Cano-Sancho, German Chaker, Jade Covaci, Adrian Creusot, Nicolas David, Arthur Debrauwer, Laurent Dervilly, Gaud Duca, Radu Corneliu Fessard, Valérie Grimalt, Joan O. Guerin, Thierry Habchi, Baninia Hecht, Helge Hollender, Juliane Jamin, Emilien L. Klánová, Jana Kosjek, Tina Krauss, Martin Lamoree, Marja Lavison-Bompard, Gwenaelle Meijer, Jeroen Moeller, Ruth Mol, Hans Mompelat, Sophie Van Nieuwenhuyse, An Oberacher, Herbert Parinet, Julien Van Poucke, Christof Roškar, Robert Togola, Anne Trontelj, Jurij Price, Elliott J. |
author_sort |
Tkalec, Žiga |
title |
Innovative analytical methodologies for characterizing chemical exposure with a view to next-generation risk assessment |
title_short |
Innovative analytical methodologies for characterizing chemical exposure with a view to next-generation risk assessment |
title_full |
Innovative analytical methodologies for characterizing chemical exposure with a view to next-generation risk assessment |
title_fullStr |
Innovative analytical methodologies for characterizing chemical exposure with a view to next-generation risk assessment |
title_full_unstemmed |
Innovative analytical methodologies for characterizing chemical exposure with a view to next-generation risk assessment |
title_sort |
innovative analytical methodologies for characterizing chemical exposure with a view to next-generation risk assessment |
publisher |
Elsevier |
publishDate |
2024-03-17 |
url |
http://hdl.handle.net/10261/352937 http://dx.doi.org/10.13039/501100000780 https://api.elsevier.com/content/abstract/scopus_id/85188785915 |
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dig-idaea-es-10261-3529372024-05-16T20:40:43Z Innovative analytical methodologies for characterizing chemical exposure with a view to next-generation risk assessment Tkalec, Žiga Antignac, Jean-Philippe Bandow, Nicole Béen, Frederic M. Belova, Lidia Bessems, Jos Le Bizec, Bruno Brack, Werner Cano-Sancho, German Chaker, Jade Covaci, Adrian Creusot, Nicolas David, Arthur Debrauwer, Laurent Dervilly, Gaud Duca, Radu Corneliu Fessard, Valérie Grimalt, Joan O. Guerin, Thierry Habchi, Baninia Hecht, Helge Hollender, Juliane Jamin, Emilien L. Klánová, Jana Kosjek, Tina Krauss, Martin Lamoree, Marja Lavison-Bompard, Gwenaelle Meijer, Jeroen Moeller, Ruth Mol, Hans Mompelat, Sophie Van Nieuwenhuyse, An Oberacher, Herbert Parinet, Julien Van Poucke, Christof Roškar, Robert Togola, Anne Trontelj, Jurij Price, Elliott J. European Commission 0000-0003-4518-3923 0000-0001-5718-0733 0000-0002-3680-4786 0000-0003-0527-1136 0000-0001-8189-1826 0000-0001-9705-167X 0000-0002-4660-274X 0000-0002-8818-5307 0000-0002-6421-0344 0000-0002-0362-4244 0000-0002-7373-7738 0000-0002-4551-6823 0000-0003-0087-6910 0000-0002-3063-1853 0000-0002-5393-1533 0000-0002-2558-1425 Sampling strategies Chemical exposure Chemical risk assessment Effect-based methods Effect-directed analysis High-resolution mass spectrometry Ensure healthy lives and promote well-being for all at all ages The chemical burden on the environment and human population is increasing. Consequently, regulatory risk assessment must keep pace to manage, reduce, and prevent adverse impacts on human and environmental health associated with hazardous chemicals. Surveillance of chemicals of known, emerging, or potential future concern, entering the environment-food-human continuum is needed to document the reality of risks posed by chemicals on ecosystem and human health from a one health perspective, feed into early warning systems and support public policies for exposure mitigation provisions and safe and sustainable by design strategies. The use of less-conventional sampling strategies and integration of full-scan, high-resolution mass spectrometry and effect-directed analysis in environmental and human monitoring programmes have the potential to enhance the screening and identification of a wider range of chemicals of known, emerging or potential future concern. Here, we outline the key needs and recommendations identified within the European Partnership for Assessment of Risks from Chemicals (PARC) project for leveraging these innovative methodologies to support the development of next-generation chemical risk assessment. This project was co-funded from the Horizon Europe programme under grant agreement 101057014 (PARC). ŽT, HH, JK and EJP acknowledge the research infrastructure RECETOX RI (LM2023069), the support from European Union’s Horizon 2020 research and innovation program under grant agreement No 857560 (CETOCOEN Excellence) and OP RDE (CZ.02.1.01/0.0/0.0/17_043/0009632) and CETOCOEN PLUS (CZ.02.1.01/0.0/0.0/15_003/0000469). LB acknowledges funding through Research Foundation Flanders (FWO) fellowship (11G1821N). AC acknowledges the FWO research infrastructure EIRENE-Flanders (FWO I001923N) and the Exposome Centre of Excellence of the University of Antwerp (BOF grant, Antigoon database number 41222). The authors kindly thank Karl Lilja, Anja Duffek, Christophe Rousselle and Lutz Ahrens for their comments and suggestions during manuscript preparation. Views and opinions expressed are those of the author(s) only and do not necessarily reflect those of the European Union or the granting authority, European Health and Digital Executive Agency (HADEA). Neither the European Union nor the granting authority can be held responsible for any use that may be made of the information it contains. Peer reviewed 2024-04-05T06:02:08Z 2024-04-05T06:02:08Z 2024-03-17 artículo http://purl.org/coar/resource_type/c_6501 Environment International 186: 108585 (2024) 01604120 http://hdl.handle.net/10261/352937 10.1016/j.envint.2024.108585 http://dx.doi.org/10.13039/501100000780 38521044 2-s2.0-85188785915 https://api.elsevier.com/content/abstract/scopus_id/85188785915 en #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/EC/H2020/857560 Environment international Publisher's version https://doi.org/10.1016/j.envint.2024.108585 Sí open Elsevier |