Linking chemical exposure and fish metabolome: Discovering new biomarkers of environmental exposure of Argyrosomus regius to the antidepressant venlafaxine
In this study, a non-target metabolomic approach was used to investigate changes in the metabolome of juvenile meagre (Argyrosomus regius) exposed to venlafaxine (20 µg/L). A total of 24, 22 and 8 endogenous metabolites tentatively identified in liver, brain and plasma, respectively, were significantly changed in venlafaxine exposed meagre, showing tissue-dependent variations in the metabolic profile. The amino acids tryptophan, tyrosine and phenylalanine, which are related to the synthesis, availability, and expression of neurotransmitters (e.g., serotonin, dopamine, epinephrine), showed to be dysregulated by venlafaxine exposure. A high impact was observed in fish brain metabolome that showed a trend of up-regulation for most of the tentatively identified metabolites. In conclusion, the identification of possible biomarkers of exposure in fish metabolome to environmental stressors such as venlafaxine is crucial to assess early signal changes at molecular level, enabling the prevention of deleterious effects at the organism and population levels.
Main Authors: | Santos, Lúcia H. M. L. M., Maulvault, Ana Luísa, Jaén-Gil, Adrián, Marques, António, Barceló, Damià, Rodríguez-Mozaz, Sara |
---|---|
Format: | artículo biblioteca |
Language: | English |
Published: |
Elsevier
2023-01-07
|
Subjects: | Pharmaceuticals, Aquatic organisms, Ecotoxicology, Molecular effects, Non-target metabolomics, |
Online Access: | http://hdl.handle.net/10261/287336 https://api.elsevier.com/content/abstract/scopus_id/85146096079 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Comprehensive study of sulfamethoxazole effects in marine mussels: Bioconcentration, enzymatic activities and metabolomics
by: Serra-Compte, Albert, et al.
Published: (2019-06) -
Comprehensive study of sulfamethoxazole effects in marine mussels: Bioconcentration, enzymatic activities and metabolomics
by: Serra-Compte, Albert, et al.
Published: (2019-06) -
Linking plant-root exudate changes to micropollutant exposure in aquatic plants (Lemna minor and Salvinia natans). A prospective metabolomic study
by: Escolà Casas, Mònica, et al.
Published: (2022-01-01) -
Targeted metabolomics of Gammarus pulex following controlled exposures to selected pharmaceuticals in water
by: Gómez-Canela, Cristian, et al.
Published: (2016-08-15) -
Effects of sulfamethoxazole exposure on mussels (Mytilus galloprovincialis) metabolome using retrospective non-target high-resolution mass spectrometry and chemometric tools
by: Pérez-López, Carlos, et al.
Published: (2022-08-05)