Does Environmental Exposure to Pharmaceutical and Personal Care Product Residues Result in the Selection of Antimicrobial-Resistant Microorganisms, and is this Important in Terms of Human Health Outcomes?
The environment plays a critical role in the development, dissemination, and transmission of antimicrobial resistance (AMR). Pharmaceuticals and personal care products (PPCPs) enter the environment through direct application to the environment and through anthropogenic pollution. Although there is a growing body of evidence defining minimal selective concentrations (MSCs) of antibiotics and the role antibiotics play in horizontal gene transfer (HGT), there is limited evidence on the role of non-antibiotic PPCPs. Existing data show associations with the development of resistance or effects on bacterial growth rather than calculating selective endpoints. Research has focused on laboratory-based systems rather than in situ experiments, although PPCP concentrations found throughout wastewater, natural water, and soil environments are often within the range of laboratory-derived MSCs and at concentrations shown to promote HGT. Increased selection and HGT of AMR by PPCPs will result in an increase in total AMR abundance in the environment, increasing the risk of exposure and potential transmission of environmental AMR to humans. There is some evidence to suggest that humans can acquire resistance from environmental settings, with water environments being the most frequently studied. However, because this is currently limited, we recommend that more evidence be gathered to understand the risk the environment plays in regard to human health. In addition, we recommend that future research efforts focus on MSC-based experiments for non-antibiotic PPCPS, particularly in situ, and investigate the effect of PPCP mixtures on AMR. Environ Toxicol Chem 2022;00:1-14. © 2022 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
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Wiley-Blackwell
2022-11-23
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Subjects: | Water quality, Antimicrobials, Personal care products, Pharmaceuticals, Soil ecotoxicology, http://metadata.un.org/sdg/6, Ensure availability and sustainable management of water and sanitation for all, |
Online Access: | http://hdl.handle.net/10261/285023 https://api.elsevier.com/content/abstract/scopus_id/85142636242 |
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dig-idaea-es-10261-2850232024-05-14T20:48:56Z Does Environmental Exposure to Pharmaceutical and Personal Care Product Residues Result in the Selection of Antimicrobial-Resistant Microorganisms, and is this Important in Terms of Human Health Outcomes? Stanton, Isobel C. Tipper, Holly J. Chau, Kevin Klümper, Uli Subirats, Jessica Murray, Aimee K. 0000-0002-2700-2407 0000-0002-1857-9204 0000-0002-6926-080X 0000-0002-4169-6548 0000-0002-7919-683X 0000-0002-1388-754X Water quality Antimicrobials Personal care products Pharmaceuticals Soil ecotoxicology http://metadata.un.org/sdg/6 Ensure availability and sustainable management of water and sanitation for all The environment plays a critical role in the development, dissemination, and transmission of antimicrobial resistance (AMR). Pharmaceuticals and personal care products (PPCPs) enter the environment through direct application to the environment and through anthropogenic pollution. Although there is a growing body of evidence defining minimal selective concentrations (MSCs) of antibiotics and the role antibiotics play in horizontal gene transfer (HGT), there is limited evidence on the role of non-antibiotic PPCPs. Existing data show associations with the development of resistance or effects on bacterial growth rather than calculating selective endpoints. Research has focused on laboratory-based systems rather than in situ experiments, although PPCP concentrations found throughout wastewater, natural water, and soil environments are often within the range of laboratory-derived MSCs and at concentrations shown to promote HGT. Increased selection and HGT of AMR by PPCPs will result in an increase in total AMR abundance in the environment, increasing the risk of exposure and potential transmission of environmental AMR to humans. There is some evidence to suggest that humans can acquire resistance from environmental settings, with water environments being the most frequently studied. However, because this is currently limited, we recommend that more evidence be gathered to understand the risk the environment plays in regard to human health. In addition, we recommend that future research efforts focus on MSC-based experiments for non-antibiotic PPCPS, particularly in situ, and investigate the effect of PPCP mixtures on AMR. Environ Toxicol Chem 2022;00:1-14. © 2022 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC. Peer reviewed 2022-12-16T09:14:25Z 2022-12-16T09:14:25Z 2022-11-23 artículo http://purl.org/coar/resource_type/c_6501 Environmental Toxicology and Chemistry (2022) 07307268 http://hdl.handle.net/10261/285023 10.1002/etc.5498 36416260 2-s2.0-85142636242 https://api.elsevier.com/content/abstract/scopus_id/85142636242 en Environmental toxicology and chemistry Publisher's version https://doi.org/10.1002/etc.5498 Sí open Wiley-Blackwell |
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Water quality Antimicrobials Personal care products Pharmaceuticals Soil ecotoxicology http://metadata.un.org/sdg/6 Ensure availability and sustainable management of water and sanitation for all Water quality Antimicrobials Personal care products Pharmaceuticals Soil ecotoxicology http://metadata.un.org/sdg/6 Ensure availability and sustainable management of water and sanitation for all |
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Water quality Antimicrobials Personal care products Pharmaceuticals Soil ecotoxicology http://metadata.un.org/sdg/6 Ensure availability and sustainable management of water and sanitation for all Water quality Antimicrobials Personal care products Pharmaceuticals Soil ecotoxicology http://metadata.un.org/sdg/6 Ensure availability and sustainable management of water and sanitation for all Stanton, Isobel C. Tipper, Holly J. Chau, Kevin Klümper, Uli Subirats, Jessica Murray, Aimee K. Does Environmental Exposure to Pharmaceutical and Personal Care Product Residues Result in the Selection of Antimicrobial-Resistant Microorganisms, and is this Important in Terms of Human Health Outcomes? |
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The environment plays a critical role in the development, dissemination, and transmission of antimicrobial resistance (AMR). Pharmaceuticals and personal care products (PPCPs) enter the environment through direct application to the environment and through anthropogenic pollution. Although there is a growing body of evidence defining minimal selective concentrations (MSCs) of antibiotics and the role antibiotics play in horizontal gene transfer (HGT), there is limited evidence on the role of non-antibiotic PPCPs. Existing data show associations with the development of resistance or effects on bacterial growth rather than calculating selective endpoints. Research has focused on laboratory-based systems rather than in situ experiments, although PPCP concentrations found throughout wastewater, natural water, and soil environments are often within the range of laboratory-derived MSCs and at concentrations shown to promote HGT. Increased selection and HGT of AMR by PPCPs will result in an increase in total AMR abundance in the environment, increasing the risk of exposure and potential transmission of environmental AMR to humans. There is some evidence to suggest that humans can acquire resistance from environmental settings, with water environments being the most frequently studied. However, because this is currently limited, we recommend that more evidence be gathered to understand the risk the environment plays in regard to human health. In addition, we recommend that future research efforts focus on MSC-based experiments for non-antibiotic PPCPS, particularly in situ, and investigate the effect of PPCP mixtures on AMR. Environ Toxicol Chem 2022;00:1-14. © 2022 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC. |
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0000-0002-2700-2407 |
author_facet |
0000-0002-2700-2407 Stanton, Isobel C. Tipper, Holly J. Chau, Kevin Klümper, Uli Subirats, Jessica Murray, Aimee K. |
format |
artículo |
topic_facet |
Water quality Antimicrobials Personal care products Pharmaceuticals Soil ecotoxicology http://metadata.un.org/sdg/6 Ensure availability and sustainable management of water and sanitation for all |
author |
Stanton, Isobel C. Tipper, Holly J. Chau, Kevin Klümper, Uli Subirats, Jessica Murray, Aimee K. |
author_sort |
Stanton, Isobel C. |
title |
Does Environmental Exposure to Pharmaceutical and Personal Care Product Residues Result in the Selection of Antimicrobial-Resistant Microorganisms, and is this Important in Terms of Human Health Outcomes? |
title_short |
Does Environmental Exposure to Pharmaceutical and Personal Care Product Residues Result in the Selection of Antimicrobial-Resistant Microorganisms, and is this Important in Terms of Human Health Outcomes? |
title_full |
Does Environmental Exposure to Pharmaceutical and Personal Care Product Residues Result in the Selection of Antimicrobial-Resistant Microorganisms, and is this Important in Terms of Human Health Outcomes? |
title_fullStr |
Does Environmental Exposure to Pharmaceutical and Personal Care Product Residues Result in the Selection of Antimicrobial-Resistant Microorganisms, and is this Important in Terms of Human Health Outcomes? |
title_full_unstemmed |
Does Environmental Exposure to Pharmaceutical and Personal Care Product Residues Result in the Selection of Antimicrobial-Resistant Microorganisms, and is this Important in Terms of Human Health Outcomes? |
title_sort |
does environmental exposure to pharmaceutical and personal care product residues result in the selection of antimicrobial-resistant microorganisms, and is this important in terms of human health outcomes? |
publisher |
Wiley-Blackwell |
publishDate |
2022-11-23 |
url |
http://hdl.handle.net/10261/285023 https://api.elsevier.com/content/abstract/scopus_id/85142636242 |
work_keys_str_mv |
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