Recent Advances in Prodigiosin as a Bioactive Compound in Nanocomposite Applications

Bionanocomposites based on natural bioactive entities have gained importance due to their abundance; renewable and environmentally benign nature; and outstanding properties with applied perspective. Additionally, their formulation with biological molecules with antimicrobial, antioxidant, and anticancer activities has been produced nowadays. The present review details the state of the art and the importance of this pyrrolic compound produced by microorganisms, with interest towards Serratia marcescens, including production strategies at a laboratory level and scale-up to bioreactors. Promising results of its biological activity have been reported to date, and the advances and applications in bionanocomposites are the most recent strategy to potentiate and to obtain new carriers for the transport and controlled release of prodigiosin. Prodigiosin, a bioactive secondary metabolite, produced by Serratia marcescens, is an effective proapoptotic agent against bacterial and fungal strains as well as cancer cell lines. Furthermore, this molecule presents antioxidant activity, which makes it ideal for treating wounds and promoting the general improvement of the immune system. Likewise, some of the characteristics of prodigiosin, such as hydrophobicity, limit its use for medical and biotechnological applications; however, this can be overcome by using it as a component of a bionanocomposite. This review focuses on the chemistry and the structure of the bionanocomposites currently developed using biorenewable resources. Moreover, the work illuminates recent developments in pyrrole-based bionanocomposites, with special insight to its application in the medical area.

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Main Authors: Araújo, Rafael G., Zavala, Natalia Rodríguez, Castillo-Zacarías, Carlos, Barocio, Mario E., Hidalgo-Vázquez, Enrique, Parra-Arroyo, Lizeth, Rodríguez-Hernández, Jesús Alfredo, Martínez-Prado, María Adriana, Sosa-Hernández, Juan Eduardo, Martínez-Ruiz, Manuel, Chen, Wei Ning, Barceló, Damià, Iqbal, Hafiz M.N., Parra-Saldívar, Roberto
Other Authors: 0000-0001-8614-9014
Format: artículo biblioteca
Language:English
Published: Multidisciplinary Digital Publishing Institute 2022-08-05
Subjects:Pyrrolic compounds, Serratia marcescens, Bionanocomposites, Biorenewable resources, Prodigiosin,
Online Access:http://hdl.handle.net/10261/279092
https://api.elsevier.com/content/abstract/scopus_id/85136952259
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spelling dig-idaea-es-10261-2790922024-10-27T21:40:09Z Recent Advances in Prodigiosin as a Bioactive Compound in Nanocomposite Applications Araújo, Rafael G. Zavala, Natalia Rodríguez Castillo-Zacarías, Carlos Barocio, Mario E. Hidalgo-Vázquez, Enrique Parra-Arroyo, Lizeth Rodríguez-Hernández, Jesús Alfredo Martínez-Prado, María Adriana Sosa-Hernández, Juan Eduardo Martínez-Ruiz, Manuel Chen, Wei Ning Barceló, Damià Iqbal, Hafiz M.N. Parra-Saldívar, Roberto 0000-0001-8614-9014 0000-0002-7896-266X 0000-0002-9142-0638 0000-0001-5441-4768 0000-0002-8200-2362 0000-0003-1111-5076 0000-0003-4855-2720 0000-0002-4958-5797 Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72] Pyrrolic compounds Serratia marcescens Bionanocomposites Biorenewable resources Prodigiosin Bionanocomposites based on natural bioactive entities have gained importance due to their abundance; renewable and environmentally benign nature; and outstanding properties with applied perspective. Additionally, their formulation with biological molecules with antimicrobial, antioxidant, and anticancer activities has been produced nowadays. The present review details the state of the art and the importance of this pyrrolic compound produced by microorganisms, with interest towards Serratia marcescens, including production strategies at a laboratory level and scale-up to bioreactors. Promising results of its biological activity have been reported to date, and the advances and applications in bionanocomposites are the most recent strategy to potentiate and to obtain new carriers for the transport and controlled release of prodigiosin. Prodigiosin, a bioactive secondary metabolite, produced by Serratia marcescens, is an effective proapoptotic agent against bacterial and fungal strains as well as cancer cell lines. Furthermore, this molecule presents antioxidant activity, which makes it ideal for treating wounds and promoting the general improvement of the immune system. Likewise, some of the characteristics of prodigiosin, such as hydrophobicity, limit its use for medical and biotechnological applications; however, this can be overcome by using it as a component of a bionanocomposite. This review focuses on the chemistry and the structure of the bionanocomposites currently developed using biorenewable resources. Moreover, the work illuminates recent developments in pyrrole-based bionanocomposites, with special insight to its application in the medical area. This work was funded by CSIC-Tecnológico de Monterrey under i-Link+program (LINKB20030) for a project entitled “Contaminantes emergentes y prioritarios en las aguas reutilizadas en agricultura: riesgos y efectos en suelos, producción agrícola y entorno ambiental”. Peer reviewed 2022-09-14T10:35:30Z 2022-09-14T10:35:30Z 2022-08-05 artículo http://purl.org/coar/resource_type/c_6501 Molecules 27 (15): 4982 (2022) http://hdl.handle.net/10261/279092 10.3390/molecules27154982 35956931 2-s2.0-85136952259 https://api.elsevier.com/content/abstract/scopus_id/85136952259 en Molecules (Basel, Switzerland) Publisher's version https://doi.org/10.3390/molecules27154982 Sí open Multidisciplinary Digital Publishing Institute
institution IDAEA ES
collection DSpace
country España
countrycode ES
component Bibliográfico
access En linea
databasecode dig-idaea-es
tag biblioteca
region Europa del Sur
libraryname Biblioteca del IDAEA España
language English
topic Pyrrolic compounds
Serratia marcescens
Bionanocomposites
Biorenewable resources
Prodigiosin
Pyrrolic compounds
Serratia marcescens
Bionanocomposites
Biorenewable resources
Prodigiosin
spellingShingle Pyrrolic compounds
Serratia marcescens
Bionanocomposites
Biorenewable resources
Prodigiosin
Pyrrolic compounds
Serratia marcescens
Bionanocomposites
Biorenewable resources
Prodigiosin
Araújo, Rafael G.
Zavala, Natalia Rodríguez
Castillo-Zacarías, Carlos
Barocio, Mario E.
Hidalgo-Vázquez, Enrique
Parra-Arroyo, Lizeth
Rodríguez-Hernández, Jesús Alfredo
Martínez-Prado, María Adriana
Sosa-Hernández, Juan Eduardo
Martínez-Ruiz, Manuel
Chen, Wei Ning
Barceló, Damià
Iqbal, Hafiz M.N.
Parra-Saldívar, Roberto
Recent Advances in Prodigiosin as a Bioactive Compound in Nanocomposite Applications
description Bionanocomposites based on natural bioactive entities have gained importance due to their abundance; renewable and environmentally benign nature; and outstanding properties with applied perspective. Additionally, their formulation with biological molecules with antimicrobial, antioxidant, and anticancer activities has been produced nowadays. The present review details the state of the art and the importance of this pyrrolic compound produced by microorganisms, with interest towards Serratia marcescens, including production strategies at a laboratory level and scale-up to bioreactors. Promising results of its biological activity have been reported to date, and the advances and applications in bionanocomposites are the most recent strategy to potentiate and to obtain new carriers for the transport and controlled release of prodigiosin. Prodigiosin, a bioactive secondary metabolite, produced by Serratia marcescens, is an effective proapoptotic agent against bacterial and fungal strains as well as cancer cell lines. Furthermore, this molecule presents antioxidant activity, which makes it ideal for treating wounds and promoting the general improvement of the immune system. Likewise, some of the characteristics of prodigiosin, such as hydrophobicity, limit its use for medical and biotechnological applications; however, this can be overcome by using it as a component of a bionanocomposite. This review focuses on the chemistry and the structure of the bionanocomposites currently developed using biorenewable resources. Moreover, the work illuminates recent developments in pyrrole-based bionanocomposites, with special insight to its application in the medical area.
author2 0000-0001-8614-9014
author_facet 0000-0001-8614-9014
Araújo, Rafael G.
Zavala, Natalia Rodríguez
Castillo-Zacarías, Carlos
Barocio, Mario E.
Hidalgo-Vázquez, Enrique
Parra-Arroyo, Lizeth
Rodríguez-Hernández, Jesús Alfredo
Martínez-Prado, María Adriana
Sosa-Hernández, Juan Eduardo
Martínez-Ruiz, Manuel
Chen, Wei Ning
Barceló, Damià
Iqbal, Hafiz M.N.
Parra-Saldívar, Roberto
format artículo
topic_facet Pyrrolic compounds
Serratia marcescens
Bionanocomposites
Biorenewable resources
Prodigiosin
author Araújo, Rafael G.
Zavala, Natalia Rodríguez
Castillo-Zacarías, Carlos
Barocio, Mario E.
Hidalgo-Vázquez, Enrique
Parra-Arroyo, Lizeth
Rodríguez-Hernández, Jesús Alfredo
Martínez-Prado, María Adriana
Sosa-Hernández, Juan Eduardo
Martínez-Ruiz, Manuel
Chen, Wei Ning
Barceló, Damià
Iqbal, Hafiz M.N.
Parra-Saldívar, Roberto
author_sort Araújo, Rafael G.
title Recent Advances in Prodigiosin as a Bioactive Compound in Nanocomposite Applications
title_short Recent Advances in Prodigiosin as a Bioactive Compound in Nanocomposite Applications
title_full Recent Advances in Prodigiosin as a Bioactive Compound in Nanocomposite Applications
title_fullStr Recent Advances in Prodigiosin as a Bioactive Compound in Nanocomposite Applications
title_full_unstemmed Recent Advances in Prodigiosin as a Bioactive Compound in Nanocomposite Applications
title_sort recent advances in prodigiosin as a bioactive compound in nanocomposite applications
publisher Multidisciplinary Digital Publishing Institute
publishDate 2022-08-05
url http://hdl.handle.net/10261/279092
https://api.elsevier.com/content/abstract/scopus_id/85136952259
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