Short-Term Changes in Respiratory Biomarkers after Swimming in a Chlorinated Pool

Font-Ribera, Laia; Kogevinas, Manolis; Zock, Jan-Paul; Gómez, Federico P.; Barreiro, Esther; Nieuwenhuijsen, Mark J.; Fernández Ramón, M. Pilar; Lourencetti, Carolina; Pérez-Olabarría, Maitane; Bustamante, Mariona; Marcos, Ricard; Grimalt, Joan O.; Villanueva, Cristina M.

Short-Term Changes in Respiratory Biomarkers after Swimming in a Chlorinated Pool

36 páginas, 3 figuras, 5 tablas.

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Main Authors:	Font-Ribera, Laia, Kogevinas, Manolis, Zock, Jan-Paul, Gómez, Federico P., Barreiro, Esther, Nieuwenhuijsen, Mark J., Fernández Ramón, M. Pilar, Lourencetti, Carolina, Pérez-Olabarría, Maitane, Bustamante, Mariona, Marcos, Ricard, Grimalt, Joan O., Villanueva, Cristina M.
Format:	artículo biblioteca
Language:	English
Published:	National Institute of Environmental Health Sciences (U.S.) 2010-09-12
Subjects:	Biomarkers, Clara cell secretory protein, Disinfection by-products, Exhaled breath condensate, Fractional exhaled nitric oxide, Respiratory health, Swimming, Swimming pools, Trihalomethanes,
Online Access:	http://hdl.handle.net/10261/27630
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record_format	koha
spelling	dig-idaea-es-10261-276302024-10-16T07:27:31Z Short-Term Changes in Respiratory Biomarkers after Swimming in a Chlorinated Pool Font-Ribera, Laia Kogevinas, Manolis Zock, Jan-Paul Gómez, Federico P. Barreiro, Esther Nieuwenhuijsen, Mark J. Fernández Ramón, M. Pilar Lourencetti, Carolina Pérez-Olabarría, Maitane Bustamante, Mariona Marcos, Ricard Grimalt, Joan O. Villanueva, Cristina M. Biomarkers Clara cell secretory protein Disinfection by-products Exhaled breath condensate Fractional exhaled nitric oxide Respiratory health Swimming Swimming pools Trihalomethanes 36 páginas, 3 figuras, 5 tablas. [BACKGROUND]: Swimming in chlorinated pools involves exposure to disinfection by-products (DBPs) and has been associated with impaired respiratory health. [OBJECTIVES]: We evaluated short-term changes in several respiratory biomarkers to explore mechanisms of potential lung damage related to swimming pool exposure. [METHODS]: We measured lung function and biomarkers of airway inflammation (fractional exhaled nitric oxide –FeNO- and 8 cytokines and 1 growth factor (VEGF) in exhaled breath condensate), oxidative stress (8-isoprostane in exhaled breath condensate), and lung permeability (surfactant protein D -SPD- and the Clara cell secretory protein -CC16- in serum) in 48 healthy non-smoking adults before and after swimming for 40 min in a chlorinated indoor swimming pool. We measured trihalomethanes in exhaled breath as a marker of individual exposure to DBPs. Energy expenditure during swimming, atopy and CC16 genotype (rs3741240) was also determined. [RESULTS]: Median serum CC16 levels increased from 6.01 to 6.21 μg/L (average increase 3.3%, paired Wilcoxon test p = 0.03), regardless of atopic status and CC16 genotype. This increase was explained both by energy expenditure and different markers of DBP exposure in multivariate models. FeNO was unchanged overall but tended to decrease among atopics. We found no significant changes in lung function, SP-D, 8-isoprostane, 8 cytokines and VEGF. [CONCLUSIONS]: A slight increase in serum CC16, a marker of lung epithelium permeability, was detected in healthy adults after swimming in an indoor chlorinated pool. Exercise and DBP exposure explained this association, without involving inflammatory mechanisms. Further research is needed to confirm the results, establish the clinical relevance of short-term serum CC16 changes, and evaluate the long-term health impacts. Work funded by the projects SAF2005-07643-C03-01; CP06/00341; CP01/3058; SAF2007-62719, FISCP06/00341 and FI06/00651. Peer reviewed 2010-09-14T12:07:32Z 2010-09-14T12:07:32Z 2010-09-12 artículo http://purl.org/coar/resource_type/c_6501 Environmental Health Perspectives (EHP): (2010) 0091-6765 http://hdl.handle.net/10261/27630 10.1289/ehp.1001961 20833607 en http://dx.doi.org/10.1289/ehp.1001961 open 258491 bytes application/pdf National Institute of Environmental Health Sciences (U.S.) National Institutes of Health (U.S.). PubMed Central Department of Health and Human Services (U.S.)
institution	IDAEA ES
collection	DSpace
country	España
countrycode	ES
component	Bibliográfico
access	En linea
databasecode	dig-idaea-es
tag	biblioteca
region	Europa del Sur
libraryname	Biblioteca del IDAEA España
language	English
topic	Biomarkers Clara cell secretory protein Disinfection by-products Exhaled breath condensate Fractional exhaled nitric oxide Respiratory health Swimming Swimming pools Trihalomethanes Biomarkers Clara cell secretory protein Disinfection by-products Exhaled breath condensate Fractional exhaled nitric oxide Respiratory health Swimming Swimming pools Trihalomethanes
spellingShingle	Biomarkers Clara cell secretory protein Disinfection by-products Exhaled breath condensate Fractional exhaled nitric oxide Respiratory health Swimming Swimming pools Trihalomethanes Biomarkers Clara cell secretory protein Disinfection by-products Exhaled breath condensate Fractional exhaled nitric oxide Respiratory health Swimming Swimming pools Trihalomethanes Font-Ribera, Laia Kogevinas, Manolis Zock, Jan-Paul Gómez, Federico P. Barreiro, Esther Nieuwenhuijsen, Mark J. Fernández Ramón, M. Pilar Lourencetti, Carolina Pérez-Olabarría, Maitane Bustamante, Mariona Marcos, Ricard Grimalt, Joan O. Villanueva, Cristina M. Short-Term Changes in Respiratory Biomarkers after Swimming in a Chlorinated Pool
description	36 páginas, 3 figuras, 5 tablas.
format	artículo
topic_facet	Biomarkers Clara cell secretory protein Disinfection by-products Exhaled breath condensate Fractional exhaled nitric oxide Respiratory health Swimming Swimming pools Trihalomethanes
author	Font-Ribera, Laia Kogevinas, Manolis Zock, Jan-Paul Gómez, Federico P. Barreiro, Esther Nieuwenhuijsen, Mark J. Fernández Ramón, M. Pilar Lourencetti, Carolina Pérez-Olabarría, Maitane Bustamante, Mariona Marcos, Ricard Grimalt, Joan O. Villanueva, Cristina M.
author_facet	Font-Ribera, Laia Kogevinas, Manolis Zock, Jan-Paul Gómez, Federico P. Barreiro, Esther Nieuwenhuijsen, Mark J. Fernández Ramón, M. Pilar Lourencetti, Carolina Pérez-Olabarría, Maitane Bustamante, Mariona Marcos, Ricard Grimalt, Joan O. Villanueva, Cristina M.
author_sort	Font-Ribera, Laia
title	Short-Term Changes in Respiratory Biomarkers after Swimming in a Chlorinated Pool
title_short	Short-Term Changes in Respiratory Biomarkers after Swimming in a Chlorinated Pool
title_full	Short-Term Changes in Respiratory Biomarkers after Swimming in a Chlorinated Pool
title_fullStr	Short-Term Changes in Respiratory Biomarkers after Swimming in a Chlorinated Pool
title_full_unstemmed	Short-Term Changes in Respiratory Biomarkers after Swimming in a Chlorinated Pool
title_sort	short-term changes in respiratory biomarkers after swimming in a chlorinated pool
publisher	National Institute of Environmental Health Sciences (U.S.)
publishDate	2010-09-12
url	http://hdl.handle.net/10261/27630
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Short-Term Changes in Respiratory Biomarkers after Swimming in a Chlorinated Pool

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