Association between serum concentrations of hexachlorobenzene and polychlorobiphenyls with thyroid hormone and liver enzymes in a sample of the general population

Association between serum concentrations of hexachlorobenzene and polychlorobiphenyls with thyroid hormone and liver enzymes in a sample of the general population

6 pages, 4 figures.-- PMID: 11171930 [PubMed].-- PMCID: PMC1740109.

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Bibliographic Details
Main Authors: Sala, María, Sunyer, Jordi, Herrero, Carmen, To-Figueras, Jordi, Grimalt, Joan O.
Format: artículo biblioteca
Language:English
Published: BMJ Publishing Group 2001-03
Subjects:Hexachlorobenzene, Environmental exposure, Thyroid, Liver enzymes,
Online Access:http://hdl.handle.net/10261/27370
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spelling dig-idaea-es-10261-273702021-12-27T16:34:06Z Association between serum concentrations of hexachlorobenzene and polychlorobiphenyls with thyroid hormone and liver enzymes in a sample of the general population Sala, María Sunyer, Jordi Herrero, Carmen To-Figueras, Jordi Grimalt, Joan O. Hexachlorobenzene Environmental exposure Thyroid Liver enzymes 6 pages, 4 figures.-- PMID: 11171930 [PubMed].-- PMCID: PMC1740109. OBJECTIVES—Hexachlorobenzene (HCB) is a highly lipophilic organochlorine compound of widespread environmental occurrence, that accumulates in the biological system. It affects the porphyrine metabolism, thyroid hormones, and the liver function in animals. Although HCB is one of the most common organochlorine compound in humans, little investigation on its health effects has been done. Polychlorobiphenyls (PCBs) are also widespread toxic environmental contaminants. The aim of the present study was to investigate the association of serum HCB and PCB concentrations with thyroid hormone status and liver enzymes in human. METHODS—Thyroid stimulating hormone (TSH), total and free thyroxine (T4), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and γ-glutamyltransferase (GGT) were measured as biological markers of thyroid and liver function in a rural population sample older than 14 years (n=192, except for TSH with n=608) highly exposed to HCB. Serum concentrations of HCB were measured by gas chromatography coupled to electron capture detection. RESULTS—After adjustment for confounding variables, there was a significant negative association between serum HCB concentrations and total T4 (a decrease of 0.32 µg/dl per each unit, ln ng/ml, of increase of HCB) and a positive association with GGT (a relative increase of 10 % per each ln unit of increase of HCB), although most subjects (92%) were within the normal range for both T4 and GGT. These associations were not modified after adjustment for total lipid content or for other organochlorine compounds. The association of T4 and GGT with PCB was smaller although significant. No association was found with the other biochemical markers. CONCLUSIONS—These results suggest that the internal dose of HCB of this population may reflect a subtle metabolic effect on thyroid function and an enzymatic induction activity. Further studies are needed to evaluate the health impact of these effects in more susceptible populations, such as infants. Peer reviewed 2010-09-01T10:08:44Z 2010-09-01T10:08:44Z 2001-03 artículo http://purl.org/coar/resource_type/c_6501 Occupational and Environmental Medicine 58(3): 172-177 (2001) 1351-0711 http://hdl.handle.net/10261/27370 10.1136/oem.58.3.172 1470-7926 11171930 en http://dx.doi.org/10.1136/oem.58.3.172 open 152657 bytes application/pdf BMJ Publishing Group
institution IDAEA ES
collection DSpace
country España
countrycode ES
component Bibliográfico
access En linea
databasecode dig-idaea-es
tag biblioteca
region Europa del Sur
libraryname Biblioteca del IDAEA España
language English
topic Hexachlorobenzene
Environmental exposure
Thyroid
Liver enzymes
Hexachlorobenzene
Environmental exposure
Thyroid
Liver enzymes
spellingShingle Hexachlorobenzene
Environmental exposure
Thyroid
Liver enzymes
Hexachlorobenzene
Environmental exposure
Thyroid
Liver enzymes
Sala, María
Sunyer, Jordi
Herrero, Carmen
To-Figueras, Jordi
Grimalt, Joan O.
Association between serum concentrations of hexachlorobenzene and polychlorobiphenyls with thyroid hormone and liver enzymes in a sample of the general population
description 6 pages, 4 figures.-- PMID: 11171930 [PubMed].-- PMCID: PMC1740109.
format artículo
topic_facet Hexachlorobenzene
Environmental exposure
Thyroid
Liver enzymes
author Sala, María
Sunyer, Jordi
Herrero, Carmen
To-Figueras, Jordi
Grimalt, Joan O.
author_facet Sala, María
Sunyer, Jordi
Herrero, Carmen
To-Figueras, Jordi
Grimalt, Joan O.
author_sort Sala, María
title Association between serum concentrations of hexachlorobenzene and polychlorobiphenyls with thyroid hormone and liver enzymes in a sample of the general population
title_short Association between serum concentrations of hexachlorobenzene and polychlorobiphenyls with thyroid hormone and liver enzymes in a sample of the general population
title_full Association between serum concentrations of hexachlorobenzene and polychlorobiphenyls with thyroid hormone and liver enzymes in a sample of the general population
title_fullStr Association between serum concentrations of hexachlorobenzene and polychlorobiphenyls with thyroid hormone and liver enzymes in a sample of the general population
title_full_unstemmed Association between serum concentrations of hexachlorobenzene and polychlorobiphenyls with thyroid hormone and liver enzymes in a sample of the general population
title_sort association between serum concentrations of hexachlorobenzene and polychlorobiphenyls with thyroid hormone and liver enzymes in a sample of the general population
publisher BMJ Publishing Group
publishDate 2001-03
url http://hdl.handle.net/10261/27370
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