Long-Term Calculation of Predicted Environmental Concentrations to Assess the Risk of Anticancer Drugs in Environmental Waters
This study reports the consumption data for 132 anticancer drugs in Catalonia (NE Spain) during the period of 2013–2017 and calculates the predicted environmental concentrations (PECs) in wastewater effluents and rivers. This long-term analysis can determine the evolution of drugs present in the environment according to prescriptions and serve as an adequate tool to determine their presence and impact. Data showed that out of 132 compounds prescribed, 77 reached wastewater effluents, which accounted for the most consumed, those excreted in the highest doses, and the least biodegradable. Once diluted in receiving river waters, only mycophenolic acid and hydroxycarbamide had PEC values higher than 10 ng L<sup>−1</sup>, which is the value set by the European Medicines Agency (EMA) to carry out further risk assessment. It was also observed that compounds present in river water are those that can pose a high risk, given their persistence and capability to bioaccumulate. Therefore, this study shows that the estimation of PEC, together with physico-chemical properties of detected compounds, is a useful tool to determine the long-term presence and fate of this new class of emerging contaminants.
Main Authors: | Domínguez-García, Pol, Gibert, Marta, Lacorte Bruguera, Silvia, Gómez-Canela, Cristian |
---|---|
Other Authors: | Ministerio de Ciencia, Innovación y Universidades (España) |
Format: | artículo biblioteca |
Language: | English |
Published: |
Multidisciplinary Digital Publishing Institute
2022-05-17
|
Subjects: | Anticancer drugs, PECs, Wastewater, River water, |
Online Access: | http://hdl.handle.net/10261/271600 http://dx.doi.org/10.13039/501100011033 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
UHPLC-HRMS data from non-targeted screening for biotransformation products of cytostatic drug imatinib
by: Tkalec, Žiga, et al.
Published: (2022-04) -
Development of predicted environmental concentrations to prioritize the occurrence of pharmaceuticals in rivers from Catalonia
by: Gómez-Canela, Cristian, et al.
Published: (2019-05-20) -
β′-Hydroxy-α,β-unsaturated ketones: A new pharmacophore for the design of anticancer drugs
by: Padrón, José M., et al.
Published: (2006-04-15) -
Marine Anticancer Agents: An Overview with a Particular Focus on Their Chemical Classes
by: Barreca, Marilia, et al.
Published: (2020-12-04) -
Self-assembling hybrid linear-dendritic block copolymers: The design of nano-carriers for lipophilic antitumoral drugs
by: Fedeli, Elisabetta, et al.
Published: (2019-01-29)