Occurrence of antibiotics in Lettuce (Lactuca sativa L.) and Radish (Raphanus sativus L.) following organic soil fertilisation under plot-scale conditions: Crop and human health implications
Recent studies have demonstrated the crop uptake of antibiotics (ABs) from soils treated with AB-carrying fertilisers. However, there is a lack of plot-scale studies linking their effects at the agronomic and metabolomic/transcriptomic level to their impact on human health. This paper assesses the plant uptake of 23 ABs following two productive cycles of lettuce and radish cropped with sewage sludge, pig slurry, the organic fraction of municipal solid waste, or chemical fertilisation under plot-scale conditions (32 plots spanning 3-10 m2 each). AB uptake by plants depended on both the vegetable and the AB class and was higher in radish than in lettuce edible parts. Levels ranged from undetectable to up to 76 ng/g (fresh weight). Repetitive organic fertilisation resulted in an increase in the concentration of ABs in lettuce leaves, but not in radish roots. Significant metabolomic and transcriptomic changes were observed following soil fertilisation. Nevertheless, a human health risk assessment indicates that the occurrence of ABs in lettuce or radish edible parts does not pose any risk. To our knowledge, this is the first holistic plot-scale study demonstrating that the use of organic fertilisers containing ABs is safe for crop security and human health.
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Format: | artículo biblioteca |
Language: | English |
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Elsevier
2022-04-30
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Subjects: | Transcriptomics, Antibiotics, Crops, Human health risk, Metabolomics, |
Online Access: | http://hdl.handle.net/10261/270482 http://dx.doi.org/10.13039/501100004837 https://api.elsevier.com/content/abstract/scopus_id/85129504903 |
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dig-idaea-es-10261-2704822024-05-15T20:37:11Z Occurrence of antibiotics in Lettuce (Lactuca sativa L.) and Radish (Raphanus sativus L.) following organic soil fertilisation under plot-scale conditions: Crop and human health implications Matamoros, Víctor Escolà Casas, Mònica Mansilla, Sylvia Tadić, Đorđe Cañameras, Nuria Carazo, Nuria Portugal, José Piña, Benjamín Díez, Sergi Bayona Termens, Josep María Ministerio de Ciencia e Innovación (España) Transcriptomics Antibiotics Crops Human health risk Metabolomics Recent studies have demonstrated the crop uptake of antibiotics (ABs) from soils treated with AB-carrying fertilisers. However, there is a lack of plot-scale studies linking their effects at the agronomic and metabolomic/transcriptomic level to their impact on human health. This paper assesses the plant uptake of 23 ABs following two productive cycles of lettuce and radish cropped with sewage sludge, pig slurry, the organic fraction of municipal solid waste, or chemical fertilisation under plot-scale conditions (32 plots spanning 3-10 m2 each). AB uptake by plants depended on both the vegetable and the AB class and was higher in radish than in lettuce edible parts. Levels ranged from undetectable to up to 76 ng/g (fresh weight). Repetitive organic fertilisation resulted in an increase in the concentration of ABs in lettuce leaves, but not in radish roots. Significant metabolomic and transcriptomic changes were observed following soil fertilisation. Nevertheless, a human health risk assessment indicates that the occurrence of ABs in lettuce or radish edible parts does not pose any risk. To our knowledge, this is the first holistic plot-scale study demonstrating that the use of organic fertilisers containing ABs is safe for crop security and human health. The authors gratefully acknowledge the financial support of the Spanish Ministry of Science and Innovation through projects AGL2017-89518-R and RTI2018-096175-B-I00. IDAEA-CSIC is a Severo Ochoa Centre of Excellence (Spanish Ministry of Science and Innovation, Project CEX2018-000794-S). Mònica Escolà Casas wishes to thank the Beatriu de Pinós 2018 grant programme (MSCA grant agreement number 801370) for the funding. Peer reviewed 2022-05-25T11:15:47Z 2022-05-25T11:15:47Z 2022-04-30 artículo http://purl.org/coar/resource_type/c_6501 Journal of Hazardous Materials 436: 129044 (2022) 03043894 http://hdl.handle.net/10261/270482 10.1016/j.jhazmat.2022.129044 http://dx.doi.org/10.13039/501100004837 35525220 2-s2.0-85129504903 https://api.elsevier.com/content/abstract/scopus_id/85129504903 en #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/MCIN/AEI/RTI2018-096175-B-I00 info:eu-repo/grantAgreement/MCIN/AEICEX2018-000794-S Journal of hazardous materials Publisher's version Sí open Elsevier |
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Transcriptomics Antibiotics Crops Human health risk Metabolomics Transcriptomics Antibiotics Crops Human health risk Metabolomics |
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Transcriptomics Antibiotics Crops Human health risk Metabolomics Transcriptomics Antibiotics Crops Human health risk Metabolomics Matamoros, Víctor Escolà Casas, Mònica Mansilla, Sylvia Tadić, Đorđe Cañameras, Nuria Carazo, Nuria Portugal, José Piña, Benjamín Díez, Sergi Bayona Termens, Josep María Occurrence of antibiotics in Lettuce (Lactuca sativa L.) and Radish (Raphanus sativus L.) following organic soil fertilisation under plot-scale conditions: Crop and human health implications |
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Recent studies have demonstrated the crop uptake of antibiotics (ABs) from soils treated with AB-carrying fertilisers. However, there is a lack of plot-scale studies linking their effects at the agronomic and metabolomic/transcriptomic level to their impact on human health. This paper assesses the plant uptake of 23 ABs following two productive cycles of lettuce and radish cropped with sewage sludge, pig slurry, the organic fraction of municipal solid waste, or chemical fertilisation under plot-scale conditions (32 plots spanning 3-10 m2 each). AB uptake by plants depended on both the vegetable and the AB class and was higher in radish than in lettuce edible parts. Levels ranged from undetectable to up to 76 ng/g (fresh weight). Repetitive organic fertilisation resulted in an increase in the concentration of ABs in lettuce leaves, but not in radish roots. Significant metabolomic and transcriptomic changes were observed following soil fertilisation. Nevertheless, a human health risk assessment indicates that the occurrence of ABs in lettuce or radish edible parts does not pose any risk. To our knowledge, this is the first holistic plot-scale study demonstrating that the use of organic fertilisers containing ABs is safe for crop security and human health. |
author2 |
Ministerio de Ciencia e Innovación (España) |
author_facet |
Ministerio de Ciencia e Innovación (España) Matamoros, Víctor Escolà Casas, Mònica Mansilla, Sylvia Tadić, Đorđe Cañameras, Nuria Carazo, Nuria Portugal, José Piña, Benjamín Díez, Sergi Bayona Termens, Josep María |
format |
artículo |
topic_facet |
Transcriptomics Antibiotics Crops Human health risk Metabolomics |
author |
Matamoros, Víctor Escolà Casas, Mònica Mansilla, Sylvia Tadić, Đorđe Cañameras, Nuria Carazo, Nuria Portugal, José Piña, Benjamín Díez, Sergi Bayona Termens, Josep María |
author_sort |
Matamoros, Víctor |
title |
Occurrence of antibiotics in Lettuce (Lactuca sativa L.) and Radish (Raphanus sativus L.) following organic soil fertilisation under plot-scale conditions: Crop and human health implications |
title_short |
Occurrence of antibiotics in Lettuce (Lactuca sativa L.) and Radish (Raphanus sativus L.) following organic soil fertilisation under plot-scale conditions: Crop and human health implications |
title_full |
Occurrence of antibiotics in Lettuce (Lactuca sativa L.) and Radish (Raphanus sativus L.) following organic soil fertilisation under plot-scale conditions: Crop and human health implications |
title_fullStr |
Occurrence of antibiotics in Lettuce (Lactuca sativa L.) and Radish (Raphanus sativus L.) following organic soil fertilisation under plot-scale conditions: Crop and human health implications |
title_full_unstemmed |
Occurrence of antibiotics in Lettuce (Lactuca sativa L.) and Radish (Raphanus sativus L.) following organic soil fertilisation under plot-scale conditions: Crop and human health implications |
title_sort |
occurrence of antibiotics in lettuce (lactuca sativa l.) and radish (raphanus sativus l.) following organic soil fertilisation under plot-scale conditions: crop and human health implications |
publisher |
Elsevier |
publishDate |
2022-04-30 |
url |
http://hdl.handle.net/10261/270482 http://dx.doi.org/10.13039/501100004837 https://api.elsevier.com/content/abstract/scopus_id/85129504903 |
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