Urinary porphyrin excretion in children is associated with exposure to organochlorine compounds

Urinary porphyrin excretion in children is associated with exposure to organochlorine compounds

4 pages, 4 tables.-- 18941586 [PubMed].-- PMCID: PMC2569103.-- Printed version published Oct 2008.

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Main Authors: Sunyer, Jordi, Álvarez-Pedrerol, Mar, To-Figueras, Jordi, Ribas-Fitó, Núria, Grimalt, Joan O., Herrero, Carmen
Format: artículo biblioteca
Language:English
Published: National Institute of Environmental Health Sciences (U.S.) 2008-06-05
Subjects:Coproporphyrins, DDE, DDT, HCB, Methylmercury, PCB-153, Porphyria, Uroporphyrins,
Online Access:http://hdl.handle.net/10261/25184
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spelling dig-idaea-es-10261-251842021-12-27T16:33:51Z Urinary porphyrin excretion in children is associated with exposure to organochlorine compounds Sunyer, Jordi Álvarez-Pedrerol, Mar To-Figueras, Jordi Ribas-Fitó, Núria Grimalt, Joan O. Herrero, Carmen Coproporphyrins DDE DDT HCB Methylmercury PCB-153 Porphyria Uroporphyrins 4 pages, 4 tables.-- 18941586 [PubMed].-- PMCID: PMC2569103.-- Printed version published Oct 2008. Background Hexachlorobenzene (HCB) and other organochlorines induce porphyria cutanea tarda (PCT) in animal studies. Evidence in humans, however, is contradictory. In neonates and adults from a population historically highly exposed to HCB (Flix, Catalonia, Spain), no relation with PCT or with porphyrin excretion was found. Objectives We aimed to analyze the association between urinary porphyrin excretion and exposure to HCB and other organochlorinated compounds in children 4 years of age. Methods Our birth cohort included all newborns from Flix and the five surrounding towns (where no airborne pollution occurred). Among the 68 children with porphyrins we measured in cord blood, 52 children 4 years of age provided blood to measure organochlorine compounds, hair for methylmercury, and urine for porphyrin excretion pattern. Results Quantitative porphyrin excretion was within the normal values. However, total porphyrins, coproporphyrin I (CPI), and coproporphyrin III (CPIII) adjusted to creatinine excretion increased with increasing levels of HCB, 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene (p,p′-DDE), 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (p,p′-DDT), and polychlorinated biphenyl congener 153 (PCB-153). We found no association with methylmercury. When we fitted multiple pollutant models, p,p′-DDE had the strongest association. We found these associations in children from both Flix and other towns, and they were independent of breast-feeding and of organochlorine and porphyrin levels at birth. Conclusion HCB at current levels did not induce porphyria or increase uroporphyrins. However, the increase of urinary coproporphyrins suggests an incipient toxic effect of the organochlorines, especially for p,p′-DDE, on the hepatic heme-synthesis pathway that differs from the major effects seen in PCT. This study was funded by the Spanish Ministry of Health (FIS-97/1102, FIS-PI041436, Red INMA G03/176, and CB06/02/0041), “Fundació La Caixa” (97/009-00 and 00/077-00), and Generalitat de Catalunya-CIRIT 1999SGR 00241. Peer reviewed 2010-06-11T08:27:57Z 2010-06-11T08:27:57Z 2008-06-05 artículo http://purl.org/coar/resource_type/c_6501 Environmental Health Perspectives 116(10): 1407–1410 (2008) 0091-6765 http://hdl.handle.net/10261/25184 10.1289/ehp.11354 1552-9924 18941586 en http://dx.doi.org/10.1289/ehp.11354 open 149460 bytes application/pdf National Institute of Environmental Health Sciences (U.S.)
institution IDAEA ES
collection DSpace
country España
countrycode ES
component Bibliográfico
access En linea
databasecode dig-idaea-es
tag biblioteca
region Europa del Sur
libraryname Biblioteca del IDAEA España
language English
topic Coproporphyrins
DDE
DDT
HCB
Methylmercury
PCB-153
Porphyria
Uroporphyrins
Coproporphyrins
DDE
DDT
HCB
Methylmercury
PCB-153
Porphyria
Uroporphyrins
spellingShingle Coproporphyrins
DDE
DDT
HCB
Methylmercury
PCB-153
Porphyria
Uroporphyrins
Coproporphyrins
DDE
DDT
HCB
Methylmercury
PCB-153
Porphyria
Uroporphyrins
Sunyer, Jordi
Álvarez-Pedrerol, Mar
To-Figueras, Jordi
Ribas-Fitó, Núria
Grimalt, Joan O.
Herrero, Carmen
Urinary porphyrin excretion in children is associated with exposure to organochlorine compounds
description 4 pages, 4 tables.-- 18941586 [PubMed].-- PMCID: PMC2569103.-- Printed version published Oct 2008.
format artículo
topic_facet Coproporphyrins
DDE
DDT
HCB
Methylmercury
PCB-153
Porphyria
Uroporphyrins
author Sunyer, Jordi
Álvarez-Pedrerol, Mar
To-Figueras, Jordi
Ribas-Fitó, Núria
Grimalt, Joan O.
Herrero, Carmen
author_facet Sunyer, Jordi
Álvarez-Pedrerol, Mar
To-Figueras, Jordi
Ribas-Fitó, Núria
Grimalt, Joan O.
Herrero, Carmen
author_sort Sunyer, Jordi
title Urinary porphyrin excretion in children is associated with exposure to organochlorine compounds
title_short Urinary porphyrin excretion in children is associated with exposure to organochlorine compounds
title_full Urinary porphyrin excretion in children is associated with exposure to organochlorine compounds
title_fullStr Urinary porphyrin excretion in children is associated with exposure to organochlorine compounds
title_full_unstemmed Urinary porphyrin excretion in children is associated with exposure to organochlorine compounds
title_sort urinary porphyrin excretion in children is associated with exposure to organochlorine compounds
publisher National Institute of Environmental Health Sciences (U.S.)
publishDate 2008-06-05
url http://hdl.handle.net/10261/25184
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