Ultra-Trace Analysis of Cyanotoxins by Liquid Chromatography Coupled to High-Resolution Mass Spectrometry

Ultra-Trace Analysis of Cyanotoxins by Liquid Chromatography Coupled to High-Resolution Mass Spectrometry

© 2020 by the authors.

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Bibliographic Details
Main Authors: Filatova, Daria G., Núñez, Óscar, Farré, Marinella
Other Authors: European Commission
Format: artículo biblioteca
Published: Multidisciplinary Digital Publishing Institute 2020-04-11
Subjects:Cyanotoxins, Surface water, High-resolution mass spectrometry,
Online Access:http://hdl.handle.net/10261/209484
http://dx.doi.org/10.13039/501100000780
http://dx.doi.org/10.13039/501100002809
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spelling dig-idaea-es-10261-2094842021-12-28T16:06:16Z Ultra-Trace Analysis of Cyanotoxins by Liquid Chromatography Coupled to High-Resolution Mass Spectrometry Filatova, Daria G. Núñez, Óscar Farré, Marinella European Commission Generalitat de Catalunya Cyanotoxins Surface water High-resolution mass spectrometry © 2020 by the authors. The increasing frequency of episodes of harmful algal blooms of cyanobacterial origin is a risk to ecosystems and human health. The main human hazard may arise from drinking water supply and recreational water use. For this reason, efficient multiclass analytical methods are needed to assess the level of cyanotoxins in water reservoirs and tackle these problems. This work describes the development of a fast, sensitive, and robust analytical method for multiclass cyanotoxins determination based on dual solid-phase extraction (SPE) procedure using a polymeric cartridge, Oasis HLB (Waters Corporation, Milford, MA, USA), and a graphitized non-porous carbon cartridge, SupelcleanTM ENVI-CarbTM (Sigma-Aldrich, St. Louis, MO, USA), followed by ultra-high-performance liquid chromatography high-resolution mass spectrometry (SPE-UHPLC-HRMS). This method enabled the analysis of cylindrospermopsin, anatoxin-a, nodularin, and seven microcystins (MC-LR, MC-RR, MC-YR, MC-LA, MC-LY, MC-LW, MC-LF). The method limits of detection (MLOD) of the validated approach were between 4 and 150 pg/L. The analytical method was applied to assess the presence of the selected toxins in 21 samples collected in three natural water reservoirs in the Ter River in Catalonia (NE of Spain) used to produce drinking water for Barcelona city (Spain). This research was funded by the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No. 722493 (NaToxAq); and by the Generalitat de Catalunya (Consolidated Research Group “2017 SGR 1404-Water and Soil Quality Unit”). Peer reviewed 2020-04-28T14:08:33Z 2020-04-28T14:08:33Z 2020-04-11 2020-04-28T14:08:34Z artículo http://purl.org/coar/resource_type/c_6501 Toxins 12(4): 247 (2020) 2072-6651 http://hdl.handle.net/10261/209484 10.3390/toxins12040247 2072-6651 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100002809 32290413 #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/EC/H2020/722493 Publisher’s version https://doi.org/10.3390/toxins12040247 Sí open Multidisciplinary Digital Publishing Institute
institution IDAEA ES
collection DSpace
country España
countrycode ES
component Bibliográfico
access En linea
databasecode dig-idaea-es
tag biblioteca
region Europa del Sur
libraryname Biblioteca del IDAEA España
topic Cyanotoxins
Surface water
High-resolution mass spectrometry
Cyanotoxins
Surface water
High-resolution mass spectrometry
spellingShingle Cyanotoxins
Surface water
High-resolution mass spectrometry
Cyanotoxins
Surface water
High-resolution mass spectrometry
Filatova, Daria G.
Núñez, Óscar
Farré, Marinella
Ultra-Trace Analysis of Cyanotoxins by Liquid Chromatography Coupled to High-Resolution Mass Spectrometry
description © 2020 by the authors.
author2 European Commission
author_facet European Commission
Filatova, Daria G.
Núñez, Óscar
Farré, Marinella
format artículo
topic_facet Cyanotoxins
Surface water
High-resolution mass spectrometry
author Filatova, Daria G.
Núñez, Óscar
Farré, Marinella
author_sort Filatova, Daria G.
title Ultra-Trace Analysis of Cyanotoxins by Liquid Chromatography Coupled to High-Resolution Mass Spectrometry
title_short Ultra-Trace Analysis of Cyanotoxins by Liquid Chromatography Coupled to High-Resolution Mass Spectrometry
title_full Ultra-Trace Analysis of Cyanotoxins by Liquid Chromatography Coupled to High-Resolution Mass Spectrometry
title_fullStr Ultra-Trace Analysis of Cyanotoxins by Liquid Chromatography Coupled to High-Resolution Mass Spectrometry
title_full_unstemmed Ultra-Trace Analysis of Cyanotoxins by Liquid Chromatography Coupled to High-Resolution Mass Spectrometry
title_sort ultra-trace analysis of cyanotoxins by liquid chromatography coupled to high-resolution mass spectrometry
publisher Multidisciplinary Digital Publishing Institute
publishDate 2020-04-11
url http://hdl.handle.net/10261/209484
http://dx.doi.org/10.13039/501100000780
http://dx.doi.org/10.13039/501100002809
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AT nunezoscar ultratraceanalysisofcyanotoxinsbyliquidchromatographycoupledtohighresolutionmassspectrometry
AT farremarinella ultratraceanalysisofcyanotoxinsbyliquidchromatographycoupledtohighresolutionmassspectrometry
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