Urinary metabolites of organophosphate and pyrethroid pesticides in children from an Italian cohort (PHIME, Trieste)

Urinary metabolites of organophosphate (OP) and pyrethroid (PYR) pesticides from seven years old children of a birth cohort study (n=199; PHIME cohort of Trieste, Italy) have been measured. Six OP and two PYR metabolites have been investigated, 2-diethylamino-6-methylpyrimidin-4-ol (DEAMPY, pirimiphos metabolite) was the one found at higher concentrations, median 3.4 ng/mL specific gravity adjusted (SG adjusted), followed by 4-nitrophenol (PNP, median 1.4 ng/mL SG adjusted) and 3,5,6-trichloro-2-pyridinol (TCPY, median 0.36 ng/mL SG adjusted), parathion and chlorpyriphos metabolites, respectively. TCPY concentrations were low in comparison to other distributions of OP metabolites in children from other studies. Accordingly, the PHIME cohort showed a distinct OP metabolite distribution with high concentrations of pirimiphos and parathion. Another specific characteristic of this cohort was the high concentration of 3-phenoxybenzoic acid (3-BPA, median 0.36 ng/mL SG adjusted), a general metabolite of PYR pesticides. Evaluation of anthropometric and socio-demographic characteristics of children and families only showed a positive association between family educational level and urinary concentrations of DEAMPY metabolite (p<0.05), which could reflect distinct dietary habits depending on the educational level. Estimated daily intakes were evaluated, all studied metabolites were found within safe levels. © 2019 Elsevier Inc.

Bibliographic Details

Main Authors:	Bravo, Natalia, Grimalt, Joan O., Bocca, Beatrice, Pino, Anna, Bin, Maura, Brumatti, Liza Vecchi, Rosolen, Valentina, Barbone, Fabio, Ronfani, Luca, Alimonti, Alessandro, Calamandrei, Gemma
Other Authors:	European Commission
Format:	artículo biblioteca
Language:	English
Published:	Elsevier 2019-09
Subjects:	Children, Estimated daily intakes, Human biomonitoring, Organophosphate pesticides, Pyrethroids,
Online Access:	http://hdl.handle.net/10261/201978 http://dx.doi.org/10.13039/501100000780
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