Multi-year inter-laboratory exercises for the analysis of illicit drugs and metabolites in wastewater: Development of a quality control system
Thirty-seven laboratories from 25 countries present the development of an inter-laboratory testing scheme for the analysis of seven illicit drug residues in standard solutions, tap- and wastewater. Almost 10 000 concentration values were evaluated: triplicates of up to five samples and 26 laboratories per year. The setup was substantially improved with experiences gained across the six repetitions (e.g. matrix type, sample conditions, spiking levels). From this, (pre-)analytical issues (e.g. pH adjustment, filtration) were revealed for specific analytes which resulted in formulation of best-practice protocols for inter-laboratory setup and analytical procedures. The results illustrate the effectiveness of the inter-laboratory setup to assess laboratory performance in the framework of wastewater-based epidemiology. The exercise proved that measurements of laboratories were of high quality (>80% satisfactory results for six out of seven analytes) and that analytical follow-up is important to assist laboratories in improving robustness of wastewater-based epidemiology results.
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Format: | artículo biblioteca |
Language: | English |
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Elsevier
2018-06
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Subjects: | Illicit drugs, Wastewater, Inter-laboratory testing, Wastewater-based epidemiology, Quality assurance, |
Online Access: | http://hdl.handle.net/10261/183540 http://dx.doi.org/10.13039/501100000921 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100003130 http://dx.doi.org/10.13039/501100000038 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100003359 http://dx.doi.org/10.13039/501100002809 http://dx.doi.org/10.13039/501100010801 |
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Illicit drugs Wastewater Inter-laboratory testing Wastewater-based epidemiology Quality assurance Illicit drugs Wastewater Inter-laboratory testing Wastewater-based epidemiology Quality assurance |
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Illicit drugs Wastewater Inter-laboratory testing Wastewater-based epidemiology Quality assurance Illicit drugs Wastewater Inter-laboratory testing Wastewater-based epidemiology Quality assurance Nuijs, Alexander van Yin Lai, Foon Been, Frederic Andrés-Costa, María Jesús Barron, Leon P. Baz-Lomba, José Antonio Berset, Jean-Daniel Benaglia, Lisa Bijlsma, Lubertus Burgard, Dan Castiglioni, S. Christophoridis, Christophoros Covaci, Adrian Voogt, Pim de Emke, Erik Fatta-Kassinos, Despo Fick, Jerker Hernández, Félix Gerber, Cobus González-Mariño, Iria Grabic, Roman Gunnar,Teemu Kannan, Kurunthachalam Karolak, Sara Kasprzyk-Hordern, Barbara Kokot, Zenon Krizman‐Matasic, Ivona Li, Angela Li, Xiqing Löve, Arndís S.C. López de Alda, Miren McCall, Ann-Kathrin Meyer, Markus R. Oberacher, Herbert O'Brien, Jake Quintana, Benito Reid, Malcolm Schneider, Serge Sadler Simoes, Susana Thomaidis, Nikolaos S. Thomas, Kevin V. Yargeau, Viviane Ort, Christoph Multi-year inter-laboratory exercises for the analysis of illicit drugs and metabolites in wastewater: Development of a quality control system |
description |
Thirty-seven laboratories from 25 countries present the development of an inter-laboratory testing scheme for the analysis of seven illicit drug residues in standard solutions, tap- and wastewater. Almost 10 000 concentration values were evaluated: triplicates of up to five samples and 26 laboratories per year. The setup was substantially improved with experiences gained across the six repetitions (e.g. matrix type, sample conditions, spiking levels). From this, (pre-)analytical issues (e.g. pH adjustment, filtration) were revealed for specific analytes which resulted in formulation of best-practice protocols for inter-laboratory setup and analytical procedures. The results illustrate the effectiveness of the inter-laboratory setup to assess laboratory performance in the framework of wastewater-based epidemiology. The exercise proved that measurements of laboratories were of high quality (>80% satisfactory results for six out of seven analytes) and that analytical follow-up is important to assist laboratories in improving robustness of wastewater-based epidemiology results. |
author2 |
European Cooperation in Science and Technology |
author_facet |
European Cooperation in Science and Technology Nuijs, Alexander van Yin Lai, Foon Been, Frederic Andrés-Costa, María Jesús Barron, Leon P. Baz-Lomba, José Antonio Berset, Jean-Daniel Benaglia, Lisa Bijlsma, Lubertus Burgard, Dan Castiglioni, S. Christophoridis, Christophoros Covaci, Adrian Voogt, Pim de Emke, Erik Fatta-Kassinos, Despo Fick, Jerker Hernández, Félix Gerber, Cobus González-Mariño, Iria Grabic, Roman Gunnar,Teemu Kannan, Kurunthachalam Karolak, Sara Kasprzyk-Hordern, Barbara Kokot, Zenon Krizman‐Matasic, Ivona Li, Angela Li, Xiqing Löve, Arndís S.C. López de Alda, Miren McCall, Ann-Kathrin Meyer, Markus R. Oberacher, Herbert O'Brien, Jake Quintana, Benito Reid, Malcolm Schneider, Serge Sadler Simoes, Susana Thomaidis, Nikolaos S. Thomas, Kevin V. Yargeau, Viviane Ort, Christoph |
format |
artículo |
topic_facet |
Illicit drugs Wastewater Inter-laboratory testing Wastewater-based epidemiology Quality assurance |
author |
Nuijs, Alexander van Yin Lai, Foon Been, Frederic Andrés-Costa, María Jesús Barron, Leon P. Baz-Lomba, José Antonio Berset, Jean-Daniel Benaglia, Lisa Bijlsma, Lubertus Burgard, Dan Castiglioni, S. Christophoridis, Christophoros Covaci, Adrian Voogt, Pim de Emke, Erik Fatta-Kassinos, Despo Fick, Jerker Hernández, Félix Gerber, Cobus González-Mariño, Iria Grabic, Roman Gunnar,Teemu Kannan, Kurunthachalam Karolak, Sara Kasprzyk-Hordern, Barbara Kokot, Zenon Krizman‐Matasic, Ivona Li, Angela Li, Xiqing Löve, Arndís S.C. López de Alda, Miren McCall, Ann-Kathrin Meyer, Markus R. Oberacher, Herbert O'Brien, Jake Quintana, Benito Reid, Malcolm Schneider, Serge Sadler Simoes, Susana Thomaidis, Nikolaos S. Thomas, Kevin V. Yargeau, Viviane Ort, Christoph |
author_sort |
Nuijs, Alexander van |
title |
Multi-year inter-laboratory exercises for the analysis of illicit drugs and metabolites in wastewater: Development of a quality control system |
title_short |
Multi-year inter-laboratory exercises for the analysis of illicit drugs and metabolites in wastewater: Development of a quality control system |
title_full |
Multi-year inter-laboratory exercises for the analysis of illicit drugs and metabolites in wastewater: Development of a quality control system |
title_fullStr |
Multi-year inter-laboratory exercises for the analysis of illicit drugs and metabolites in wastewater: Development of a quality control system |
title_full_unstemmed |
Multi-year inter-laboratory exercises for the analysis of illicit drugs and metabolites in wastewater: Development of a quality control system |
title_sort |
multi-year inter-laboratory exercises for the analysis of illicit drugs and metabolites in wastewater: development of a quality control system |
publisher |
Elsevier |
publishDate |
2018-06 |
url |
http://hdl.handle.net/10261/183540 http://dx.doi.org/10.13039/501100000921 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100003130 http://dx.doi.org/10.13039/501100000038 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100003359 http://dx.doi.org/10.13039/501100002809 http://dx.doi.org/10.13039/501100010801 |
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dig-idaea-es-10261-1835402022-10-07T08:54:57Z Multi-year inter-laboratory exercises for the analysis of illicit drugs and metabolites in wastewater: Development of a quality control system Nuijs, Alexander van Yin Lai, Foon Been, Frederic Andrés-Costa, María Jesús Barron, Leon P. Baz-Lomba, José Antonio Berset, Jean-Daniel Benaglia, Lisa Bijlsma, Lubertus Burgard, Dan Castiglioni, S. Christophoridis, Christophoros Covaci, Adrian Voogt, Pim de Emke, Erik Fatta-Kassinos, Despo Fick, Jerker Hernández, Félix Gerber, Cobus González-Mariño, Iria Grabic, Roman Gunnar,Teemu Kannan, Kurunthachalam Karolak, Sara Kasprzyk-Hordern, Barbara Kokot, Zenon Krizman‐Matasic, Ivona Li, Angela Li, Xiqing Löve, Arndís S.C. López de Alda, Miren McCall, Ann-Kathrin Meyer, Markus R. Oberacher, Herbert O'Brien, Jake Quintana, Benito Reid, Malcolm Schneider, Serge Sadler Simoes, Susana Thomaidis, Nikolaos S. Thomas, Kevin V. Yargeau, Viviane Ort, Christoph European Cooperation in Science and Technology Ministerio de Economía y Competitividad (España) Research Foundation - Flanders Generalitat Valenciana Xunta de Galicia Office for Combating Narcotic Drug Abuse (Republic of Croatia) Generalitat de Catalunya Natural Sciences and Engineering Research Council of Canada Ministry of Education, Youth and Sports (Czech Republic) Swiss National Science Foundation European Commission Been, Frederic [0000-0001-5910-3248] Covaci, Adrian [orcid.org/0000-0003-0527-1136] Voogt, Pim de [0000-0001-9065-9797] Emke, Erik [0000-0002-8441-1709] Fick, Jerker [0000-0002-3949-7371] Hernández, Félix [0000-0003-1268-3083] Kasprzyk-Hordern, Barbara [0000-0002-6809-2875] Li, Xiqing [0000-0002-3162-5068] López de Alda, Miren [0000-0002-9347-2765] Quintana, Benito [0000-0002-2566-8133] Ort, Christoph [0000-0001-9950-2286] Illicit drugs Wastewater Inter-laboratory testing Wastewater-based epidemiology Quality assurance Thirty-seven laboratories from 25 countries present the development of an inter-laboratory testing scheme for the analysis of seven illicit drug residues in standard solutions, tap- and wastewater. Almost 10 000 concentration values were evaluated: triplicates of up to five samples and 26 laboratories per year. The setup was substantially improved with experiences gained across the six repetitions (e.g. matrix type, sample conditions, spiking levels). From this, (pre-)analytical issues (e.g. pH adjustment, filtration) were revealed for specific analytes which resulted in formulation of best-practice protocols for inter-laboratory setup and analytical procedures. The results illustrate the effectiveness of the inter-laboratory setup to assess laboratory performance in the framework of wastewater-based epidemiology. The exercise proved that measurements of laboratories were of high quality (>80% satisfactory results for six out of seven analytes) and that analytical follow-up is important to assist laboratories in improving robustness of wastewater-based epidemiology results. This article is based upon work from COST Action ES1307 supported by COST (European Cooperation in Science and Technology). We wish to acknowledge EMCDDA and Yeonsuk Ryu for support in the organization of the scheme and assistance in the preparation of the test samples, respectively. The following funding sources are acknowledged: the Research Foundation – Flanders (FWO) (Grant number: 1285216N), the Spanish Ministry of Economy, Industry and Competitiveness, the Generalitat Valenciana, Xunta de Galicia, Stavros Niarchos Foundation, Office for Combating Narcotic Drug Abuse of the Government of the Republic of Croatia, EU FP7 project SOLUTIONS (603437), the Government of Catalonia, the Natural Sciences and Engineering Research Council of Canada (NSERC), Ministry of Education, Youth and Sports of the Czech Republic (projects CENAKVA and CENAKVA II), EU Marie Skłodowska-Curie Fellowship (APOLLO 749845) and the Swiss National Science Foundation (SNSF, P2LAP2_164892). The following persons are acknowledged for help in sample analysis: Marijan Ahel, Evroula Hapeshi, Popi Karaolia, Esther López-García, Nicola Mastroianni, Cristina Postigo, Inés Racamonde, Rosario Rodil, Isaac Rodríguez, Tania Rodríguez-Álvarez, Ivan Senta, and Senka Terzic. Peer reviewed 2019-06-06T13:00:18Z 2019-06-06T13:00:18Z 2018-06 artículo http://purl.org/coar/resource_type/c_6501 TRAC - Trends in Analytical Chemistry 103: 34-43 (2018) 0165-9936 http://hdl.handle.net/10261/183540 10.1016/j.trac.2018.03.009 http://dx.doi.org/10.13039/501100000921 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100003130 http://dx.doi.org/10.13039/501100000038 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100003359 http://dx.doi.org/10.13039/501100002809 http://dx.doi.org/10.13039/501100010801 en #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/EC/FP7/603437 info:eu-repo/grantAgreement/EC/H2020/749845 http://dx.doi.org/10.1016/j.trac.2018.03.009 Sí none Elsevier |