Organochlorine exposure and colorectal cancer risk

Organochlorine exposure and colorectal cancer risk

7 pages, 6 tables.-- PMID: 15531428 [PubMed].-- PMCID: PMC1247607.-- Printed version published Nov 2004.

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Main Authors: Howsam, Mike, Grimalt, Joan O., Guinó, Elisabet, Navarro, Matilde, Martí-Ragué, Juan, Peinado, Miguel A., Capellá, Gabriel
Format: artículo biblioteca
Language:English
Published: National Institute of Environmental Health Sciences (U.S.) 2004-07-15
Subjects:Case-control study, Colorectal cancer, K-ras mutations, Organochlorines, p53 mutations, PCBs,
Online Access:http://hdl.handle.net/10261/16631
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spelling dig-idaea-es-10261-166312021-12-27T16:33:41Z Organochlorine exposure and colorectal cancer risk Howsam, Mike Grimalt, Joan O. Guinó, Elisabet Navarro, Matilde Martí-Ragué, Juan Peinado, Miguel A. Capellá, Gabriel Case-control study Colorectal cancer K-ras mutations Organochlorines p53 mutations PCBs 7 pages, 6 tables.-- PMID: 15531428 [PubMed].-- PMCID: PMC1247607.-- Printed version published Nov 2004. Organochlorine compounds have been linked to increased risk of several cancers. Despite reductions in their use and fugitive release, they remain one of the most important groups of persistent pollutants to which humans are exposed, primarily through dietary intake. We designed a case-control study to assess the risk of colorectal cancer with exposure to these chemicals, and their potential interactions with genetic alterations in the tumors. A subsample of cases (n = 132) and hospital controls (n = 76) was selected from a larger case-control study in Barcelona, Catalonia, Spain. We measured concentrations in serum of several organochlorines by gas chromatography. We assessed point mutations in K-ras and p53 genes in tissue samples by polymerase chain reaction/single-strand conformation polymorphism and assessed expression of p53 protein by immunohistochemical methods. An elevated risk of colorectal cancer was associated with higher serum concentrations of mono-ortho polychlorinated biphenyl (PCB) congeners 28 and 118. The odds ratio for these mono-ortho PCBs for middle and higher tertile were, respectively, 1.82 [95% confidence interval (CI) , 0.90-3.70] and 2.94 (95% CI, 1.39-6.20) . alpha-Hexachlorocyclohexane, hexachlorobenzene, and p,p´-DDE (4,4´-dichlorodiphenyltrichloroethene) showed nonsignificant increases in risk. Risk associated with mono-ortho PCBs was slightly higher for tumors with mutations in the p53 gene but was not modified by mutations in K-ras. Mono-ortho PCBs were further associated with transversion-type mutations in both genes. These results generate the hypothesis that exposure to mono-ortho PCBs contributes to human colorectal cancer development. The trend and magnitude of the association, as well as the observation of a molecular fingerprint in tumors, raise the possibility that this finding may be causal. The study was supported by grants from the Fundació La Marató de TV3 (48/95), the Spanish Fondo de Investigaciones Sanitarias (FIS 96/0797, FIS 00/0027, FIS 01/1264, FIS 03/0114, ISCIII, Red de Centros RCESP C03/09, and Red de Centros de Cancer C03/10) and Comisión Interministerial de Ciencia y Tecnología (SAF 00/81), and a European Union Marie Curie Fellowship for M.H. (HPMFCT 2000-00888). Peer reviewed 2009-09-04T09:25:59Z 2009-09-04T09:25:59Z 2004-07-15 artículo http://purl.org/coar/resource_type/c_6501 Environmental Health Perspectives 112(15): 1460-1466 (2004) 0091-6765 http://hdl.handle.net/10261/16631 10.1289/ehp.7143 1552-9924 15531428 en http://dx.doi.org/10.1289/ehp.7143 open 137601 bytes application/pdf National Institute of Environmental Health Sciences (U.S.)
institution IDAEA ES
collection DSpace
country España
countrycode ES
component Bibliográfico
access En linea
databasecode dig-idaea-es
tag biblioteca
region Europa del Sur
libraryname Biblioteca del IDAEA España
language English
topic Case-control study
Colorectal cancer
K-ras mutations
Organochlorines
p53 mutations
PCBs
Case-control study
Colorectal cancer
K-ras mutations
Organochlorines
p53 mutations
PCBs
spellingShingle Case-control study
Colorectal cancer
K-ras mutations
Organochlorines
p53 mutations
PCBs
Case-control study
Colorectal cancer
K-ras mutations
Organochlorines
p53 mutations
PCBs
Howsam, Mike
Grimalt, Joan O.
Guinó, Elisabet
Navarro, Matilde
Martí-Ragué, Juan
Peinado, Miguel A.
Capellá, Gabriel
Organochlorine exposure and colorectal cancer risk
description 7 pages, 6 tables.-- PMID: 15531428 [PubMed].-- PMCID: PMC1247607.-- Printed version published Nov 2004.
format artículo
topic_facet Case-control study
Colorectal cancer
K-ras mutations
Organochlorines
p53 mutations
PCBs
author Howsam, Mike
Grimalt, Joan O.
Guinó, Elisabet
Navarro, Matilde
Martí-Ragué, Juan
Peinado, Miguel A.
Capellá, Gabriel
author_facet Howsam, Mike
Grimalt, Joan O.
Guinó, Elisabet
Navarro, Matilde
Martí-Ragué, Juan
Peinado, Miguel A.
Capellá, Gabriel
author_sort Howsam, Mike
title Organochlorine exposure and colorectal cancer risk
title_short Organochlorine exposure and colorectal cancer risk
title_full Organochlorine exposure and colorectal cancer risk
title_fullStr Organochlorine exposure and colorectal cancer risk
title_full_unstemmed Organochlorine exposure and colorectal cancer risk
title_sort organochlorine exposure and colorectal cancer risk
publisher National Institute of Environmental Health Sciences (U.S.)
publishDate 2004-07-15
url http://hdl.handle.net/10261/16631
work_keys_str_mv AT howsammike organochlorineexposureandcolorectalcancerrisk
AT grimaltjoano organochlorineexposureandcolorectalcancerrisk
AT guinoelisabet organochlorineexposureandcolorectalcancerrisk
AT navarromatilde organochlorineexposureandcolorectalcancerrisk
AT martiraguejuan organochlorineexposureandcolorectalcancerrisk
AT peinadomiguela organochlorineexposureandcolorectalcancerrisk
AT capellagabriel organochlorineexposureandcolorectalcancerrisk
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