Drospirenone effects in hepatic metabolism and gonadal gene expression in european sea bass (Dicentrarchus Labrax)

Drospirenone effects in hepatic metabolism and gonadal gene expression in european sea bass (Dicentrarchus Labrax)

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International Congress on the Biology of Fish (ICBF2014), 3-7 August, 2014 Heriot-Watt University, Edinburgh.-- 2 pages

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Main Authors: Blanco, María, Fernandes, Denise, Medina, Paula, Blázquez, Mercedes, Porte Visa, Cinta
Format: póster de congreso biblioteca
Online Access:http://hdl.handle.net/10261/126321
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spelling dig-idaea-es-10261-1263212020-07-03T12:32:21Z Drospirenone effects in hepatic metabolism and gonadal gene expression in european sea bass (Dicentrarchus Labrax) Blanco, María Fernandes, Denise Medina, Paula Blázquez, Mercedes Porte Visa, Cinta International Congress on the Biology of Fish (ICBF2014), 3-7 August, 2014 Heriot-Watt University, Edinburgh.-- 2 pages The presence of progestagens in aquatic systems via waste-water effluents has significantly increased in the last decade. Drospirenone is one of the most widely used progestagens in contraceptive treatments and hormone replacement therapy. In a previous work, we reported drospirenone to inhibit CYP17 and CYP11ß activities in carp subcellular fraction at the low nM range. Nonetheless, no information is available about in vivo effects in fish. Thus, juvenile European sea bass (Dicentrarchus labrax) were exposed to different concentrations of drospirenone through the food (0.01, 0.1, 1 and 10 mg/Kg) for up to 31 days in order to investigate in vivo toxicological effects. 7-Ethoxyresorufin-O-deethylase (EROD), 7-benzyloxy-4-trifluoromethyl-coumarin O-debenzyloxylase (BFCOD), UDP-glucuronyltransferase (UDPGT) and sulfotransferase activities were determined in liver. Gene expression levels of cyp19a1a, cyp11ß and cyp17a1 in gonads were quantified using qRT-PCR. Plasma samples analysed by HPLC-MS/MS allowed the detection of drospirenone circulating in fish blood. However, no significant differences between control and exposed fish were detected for any of the analysed end-points, apart from higher expression of cyp17a1 in exposed females in comparison to controls. This study evidences no alteration of the hepatic metabolism in juvenile sea bass exposed to drospirenone. Peer Reviewed 2014-08-03 2015-12-02T09:37:54Z póster de congreso http://purl.org/coar/resource_type/c_6670 Abstract Book. International Congress on the Biology of Fish 3-7 August, 2014 Heriot-Watt University, Edinburgh: 56-57 (2014) http://hdl.handle.net/10261/126321 http://www2.hw.ac.uk/sls/icbf2014/SciProg.htm Sí none
institution IDAEA ES
collection DSpace
country España
countrycode ES
component Bibliográfico
access En linea
databasecode dig-idaea-es
tag biblioteca
region Europa del Sur
libraryname Biblioteca del IDAEA España
description International Congress on the Biology of Fish (ICBF2014), 3-7 August, 2014 Heriot-Watt University, Edinburgh.-- 2 pages
format póster de congreso
author Blanco, María
Fernandes, Denise
Medina, Paula
Blázquez, Mercedes
Porte Visa, Cinta
spellingShingle Blanco, María
Fernandes, Denise
Medina, Paula
Blázquez, Mercedes
Porte Visa, Cinta
Drospirenone effects in hepatic metabolism and gonadal gene expression in european sea bass (Dicentrarchus Labrax)
author_facet Blanco, María
Fernandes, Denise
Medina, Paula
Blázquez, Mercedes
Porte Visa, Cinta
author_sort Blanco, María
title Drospirenone effects in hepatic metabolism and gonadal gene expression in european sea bass (Dicentrarchus Labrax)
title_short Drospirenone effects in hepatic metabolism and gonadal gene expression in european sea bass (Dicentrarchus Labrax)
title_full Drospirenone effects in hepatic metabolism and gonadal gene expression in european sea bass (Dicentrarchus Labrax)
title_fullStr Drospirenone effects in hepatic metabolism and gonadal gene expression in european sea bass (Dicentrarchus Labrax)
title_full_unstemmed Drospirenone effects in hepatic metabolism and gonadal gene expression in european sea bass (Dicentrarchus Labrax)
title_sort drospirenone effects in hepatic metabolism and gonadal gene expression in european sea bass (dicentrarchus labrax)
url http://hdl.handle.net/10261/126321
work_keys_str_mv AT blancomaria drospirenoneeffectsinhepaticmetabolismandgonadalgeneexpressionineuropeanseabassdicentrarchuslabrax
AT fernandesdenise drospirenoneeffectsinhepaticmetabolismandgonadalgeneexpressionineuropeanseabassdicentrarchuslabrax
AT medinapaula drospirenoneeffectsinhepaticmetabolismandgonadalgeneexpressionineuropeanseabassdicentrarchuslabrax
AT blazquezmercedes drospirenoneeffectsinhepaticmetabolismandgonadalgeneexpressionineuropeanseabassdicentrarchuslabrax
AT portevisacinta drospirenoneeffectsinhepaticmetabolismandgonadalgeneexpressionineuropeanseabassdicentrarchuslabrax
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