Biofilm switch and immune response determinants at early stages of infection

Biofilm development is recognized as a major virulence factor underlying most chronic bacterial infections. When a biofilm community is established, planktonic cells growing in the surroundings of a tissue switch to a sessile lifestyle and start producing a biofilm matrix. The initial steps of in vivo biofilm development are poorly characterized and difficult to assess experimentally. A great amount of in vitro evidence has shown that accumulation of high levels of cyclic dinucleotides (c-di-NMPs) is the most prevalent hallmark governing the initiation of biofilm development by bacteria. As mentioned above, recent studies also link detection of c-di-NMPs by host cells with the activation of a type I interferon immune response against bacterial infections. We discuss here c-di-NMP signaling and the host immune response in the context of the initial steps of in vivo biofilm development. © 2013 Elsevier Ltd.

Bibliographic Details

Main Authors:	Valle Turrillas, Jaione, Solano Goñi, Cristina, García, Begoña, Toledo-Arana, Alejandro, Lasa, Íñigo
Format:	artículo biblioteca
Published:	Elsevier 2013
Subjects:	Innate immune response, Chronic infection, Biofilms, c-di-GMP, STING, cGAS, PAMPsType I interferon,
Online Access:	http://hdl.handle.net/10261/97197
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