Ovine TRIM5α can restrict visna/maedi virus
The restrictive properties of tripartite motif-containing 5 alpha (TRIM5α) from small ruminant species have not been explored. Here, we identify highly similar TRIM5α sequences in sheep and goats. Cells transduced with ovine TRIM5α effectively restricted the lentivirus visna/maedi virus DNA synthesis. Proteasome inhibition in cells transduced with ovine TRIM5α restored restricted viral DNA synthesis, suggesting a conserved mechanism of restriction. Identification of TRIM5α active molecular species may open new prophylactic strategies against lentiviral infections. © 2012, American Society for Microbiology.
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American Society for Microbiology
2012-06
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dig-idab-es-10261-867242021-12-27T15:54:45Z Ovine TRIM5α can restrict visna/maedi virus Jáuregui, Paula Crespo, Helena Glaria, Idoia Luján, Lluís Contreras, A. Rosati, Sergio Andrés, Damián F. de Amorena Zabalza, Beatriz Towers, Greg J. Reina, Ramsés The restrictive properties of tripartite motif-containing 5 alpha (TRIM5α) from small ruminant species have not been explored. Here, we identify highly similar TRIM5α sequences in sheep and goats. Cells transduced with ovine TRIM5α effectively restricted the lentivirus visna/maedi virus DNA synthesis. Proteasome inhibition in cells transduced with ovine TRIM5α restored restricted viral DNA synthesis, suggesting a conserved mechanism of restriction. Identification of TRIM5α active molecular species may open new prophylactic strategies against lentiviral infections. © 2012, American Society for Microbiology. This work was supported by grants from CICYT (no. AGL2010-22341-C04-01), the Government of Navarra (no. IIQ14064.RI1), the UK Medical Research Centre, and the UK National Institute of Health Research UCL/UCLH Comprehensive Biomedical Research Centre and fellowships from the Spanish Ministry of Science and Innovation (P.J.) and the Wellcome Trust (G.J.T.). Peer Reviewed 2013-11-14T12:20:18Z 2013-11-14T12:20:18Z 2012-06 2013-11-14T12:20:18Z artículo http://purl.org/coar/resource_type/c_6501 doi: 10.1128/JVI.00440-12 issn: 0022-538X e-issn: 1098-5514 Journal of Virology 86(17): 9504-9509 (2012) http://hdl.handle.net/10261/86724 10.1128/JVI.00440-12 22696640 en Postprint http://dx.doi.org/10.1128/JVI.00440-12 open American Society for Microbiology |
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The restrictive properties of tripartite motif-containing 5 alpha (TRIM5α) from small ruminant species have not been explored. Here, we identify highly similar TRIM5α sequences in sheep and goats. Cells transduced with ovine TRIM5α effectively restricted the lentivirus visna/maedi virus DNA synthesis. Proteasome inhibition in cells transduced with ovine TRIM5α restored restricted viral DNA synthesis, suggesting a conserved mechanism of restriction. Identification of TRIM5α active molecular species may open new prophylactic strategies against lentiviral infections. © 2012, American Society for Microbiology. |
| format |
artículo |
| author |
Jáuregui, Paula Crespo, Helena Glaria, Idoia Luján, Lluís Contreras, A. Rosati, Sergio Andrés, Damián F. de Amorena Zabalza, Beatriz Towers, Greg J. Reina, Ramsés |
| spellingShingle |
Jáuregui, Paula Crespo, Helena Glaria, Idoia Luján, Lluís Contreras, A. Rosati, Sergio Andrés, Damián F. de Amorena Zabalza, Beatriz Towers, Greg J. Reina, Ramsés Ovine TRIM5α can restrict visna/maedi virus |
| author_facet |
Jáuregui, Paula Crespo, Helena Glaria, Idoia Luján, Lluís Contreras, A. Rosati, Sergio Andrés, Damián F. de Amorena Zabalza, Beatriz Towers, Greg J. Reina, Ramsés |
| author_sort |
Jáuregui, Paula |
| title |
Ovine TRIM5α can restrict visna/maedi virus |
| title_short |
Ovine TRIM5α can restrict visna/maedi virus |
| title_full |
Ovine TRIM5α can restrict visna/maedi virus |
| title_fullStr |
Ovine TRIM5α can restrict visna/maedi virus |
| title_full_unstemmed |
Ovine TRIM5α can restrict visna/maedi virus |
| title_sort |
ovine trim5α can restrict visna/maedi virus |
| publisher |
American Society for Microbiology |
| publishDate |
2012-06 |
| url |
http://hdl.handle.net/10261/86724 |
| work_keys_str_mv |
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