Ovine TRIM5α can restrict visna/maedi virus

Ovine TRIM5α can restrict visna/maedi virus

The restrictive properties of tripartite motif-containing 5 alpha (TRIM5α) from small ruminant species have not been explored. Here, we identify highly similar TRIM5α sequences in sheep and goats. Cells transduced with ovine TRIM5α effectively restricted the lentivirus visna/maedi virus DNA synthesis. Proteasome inhibition in cells transduced with ovine TRIM5α restored restricted viral DNA synthesis, suggesting a conserved mechanism of restriction. Identification of TRIM5α active molecular species may open new prophylactic strategies against lentiviral infections. © 2012, American Society for Microbiology.

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Bibliographic Details
Main Authors: Jáuregui, Paula, Crespo, Helena, Glaria, Idoia, Luján, Lluís, Contreras, A., Rosati, Sergio, Andrés, Damián F. de, Amorena Zabalza, Beatriz, Towers, Greg J., Reina, Ramsés
Format: artículo biblioteca
Language:English
Published: American Society for Microbiology 2012-06
Online Access:http://hdl.handle.net/10261/86724
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Summary:The restrictive properties of tripartite motif-containing 5 alpha (TRIM5α) from small ruminant species have not been explored. Here, we identify highly similar TRIM5α sequences in sheep and goats. Cells transduced with ovine TRIM5α effectively restricted the lentivirus visna/maedi virus DNA synthesis. Proteasome inhibition in cells transduced with ovine TRIM5α restored restricted viral DNA synthesis, suggesting a conserved mechanism of restriction. Identification of TRIM5α active molecular species may open new prophylactic strategies against lentiviral infections. © 2012, American Society for Microbiology.

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