Patterns of Lesion and Local Host Cellular Immune Response in Natural Cases of Ovine Maedi-Visna
10 páginas.
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| Format: | artículo biblioteca |
| Language: | English |
| Published: |
Elsevier
2012
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| Subjects: | Immunopathology, Lentivirus, Maedi-visna, Sheep, |
| Online Access: | http://hdl.handle.net/10261/73100 |
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dig-idab-es-10261-731002021-04-13T15:28:21Z Patterns of Lesion and Local Host Cellular Immune Response in Natural Cases of Ovine Maedi-Visna Polledo, Laura González, J. Benavides, Julio Morales, S. Martínez-Fernández, B. Delgado, L. Reina, Ramsés Glaria, Idoia Pérez Pérez, Valentín Pérez Pérez, Valentín Ferreras, Mª del Carmen García Marín, Juan Francisco Immunopathology Lentivirus Maedi-visna Sheep 10 páginas. This study investigates the nervous form of ovine maedi-visna by histological and immunohistochemical techniques. The aim was to study the lesion types and the local cellular immune response related to each lesion type, and the possible relationship between these parameters. Thirty-four Assaf ewes were studied, 29 of which had shown nervous signs. Microscopical lesion patterns were described according to location, extent and predominance of inflammatory cell type. Immunohistochemical labelling of T cells (CD3(+), CD4(+), CD8(+) and cells expressing the gamma delta form of the T-cell receptor), B cells and macrophages revealed clear differences between the lesion patterns. Two main lesion types were described. Lymphocytic lesions had areas of mild-moderate injury characterized by a predominance of infiltrating T cells. Histiocytic lesions were more severe and had extensive areas of malacia and dominant infiltration by macrophages and B cells. Each animal had a unique lesion pattern and these differences could be due to individual resistance to the progression of infection. The lymphocytic lesions appear to represent initial or latent phases of slow progression, in which the animal presents some natural resistance to the infection. The histiocytic pattern may reflect a poor immune response or a greater virulence of the viral strain. Spanish Ministry of Education AGL2007-66874-CO4-04/CAN Ministry of Education AP2007-02007 Peer reviewed 2013-03-27T11:37:40Z 2013-03-27T11:37:40Z 2012 artículo http://purl.org/coar/resource_type/c_6501 Journal of Comparative Pathology 147(1): 1-10 (2012) 0021-9975 http://hdl.handle.net/10261/73100 10.1016/j.jcpa.2011.09.003 en http://dx.doi.org/10.1016/j.jcpa.2011.09.003 open Elsevier |
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biblioteca |
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Europa del Sur |
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Biblioteca del IDAB España |
| language |
English |
| topic |
Immunopathology Lentivirus Maedi-visna Sheep Immunopathology Lentivirus Maedi-visna Sheep |
| spellingShingle |
Immunopathology Lentivirus Maedi-visna Sheep Immunopathology Lentivirus Maedi-visna Sheep Polledo, Laura González, J. Benavides, Julio Morales, S. Martínez-Fernández, B. Delgado, L. Reina, Ramsés Glaria, Idoia Pérez Pérez, Valentín Pérez Pérez, Valentín Ferreras, Mª del Carmen García Marín, Juan Francisco Patterns of Lesion and Local Host Cellular Immune Response in Natural Cases of Ovine Maedi-Visna |
| description |
10 páginas. |
| format |
artículo |
| topic_facet |
Immunopathology Lentivirus Maedi-visna Sheep |
| author |
Polledo, Laura González, J. Benavides, Julio Morales, S. Martínez-Fernández, B. Delgado, L. Reina, Ramsés Glaria, Idoia Pérez Pérez, Valentín Pérez Pérez, Valentín Ferreras, Mª del Carmen García Marín, Juan Francisco |
| author_facet |
Polledo, Laura González, J. Benavides, Julio Morales, S. Martínez-Fernández, B. Delgado, L. Reina, Ramsés Glaria, Idoia Pérez Pérez, Valentín Pérez Pérez, Valentín Ferreras, Mª del Carmen García Marín, Juan Francisco |
| author_sort |
Polledo, Laura |
| title |
Patterns of Lesion and Local Host Cellular Immune Response in Natural Cases of Ovine Maedi-Visna |
| title_short |
Patterns of Lesion and Local Host Cellular Immune Response in Natural Cases of Ovine Maedi-Visna |
| title_full |
Patterns of Lesion and Local Host Cellular Immune Response in Natural Cases of Ovine Maedi-Visna |
| title_fullStr |
Patterns of Lesion and Local Host Cellular Immune Response in Natural Cases of Ovine Maedi-Visna |
| title_full_unstemmed |
Patterns of Lesion and Local Host Cellular Immune Response in Natural Cases of Ovine Maedi-Visna |
| title_sort |
patterns of lesion and local host cellular immune response in natural cases of ovine maedi-visna |
| publisher |
Elsevier |
| publishDate |
2012 |
| url |
http://hdl.handle.net/10261/73100 |
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